id | C00031757 |
---|---|
Name | Eckol |
CAS RN | 88798-74-7 |
Standard InChI | InChI=1S/C18H12O9/c19-7-1-8(20)3-10(2-7)25-16-12(23)6-13(24)17-18(16)27-15-11(22)4-9(21)5-14(15)26-17/h1-6,19-24H |
Standard InChI (Main Layer) | InChI=1S/C18H12O9/c19-7-1-8(20)3-10(2-7)25-16-12(23)6-13(24)17-18(16)27-15-11(22)4-9(21)5-14(15)26-17/h1-6,19-24H |
Phytochemical cluster | |
---|---|
KCF-S cluster | No. 1893 |
By standard InChI | CHEMBL471187 |
---|---|
By standard InChI Main Layer | CHEMBL471187 |
By LinkDB |
---|
By CAS RN | C060311 |
---|
class name | count |
---|
family name | count |
---|---|
Lessoniaceae | 2 |
KNApSAcK organism | *ID | *family | *plant class | *kingdom |
---|---|---|---|---|
Ecklonia stolonifera OKAMURA | 105406 | Lessoniaceae | Eukaryota | |
Eisenia bicyclis | 6395 | Lessoniaceae | Eukaryota |
accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
---|---|---|---|---|---|
P56817 | Beta-secretase 1 | A1A | CHEMBL471187 |
CHEMBL1117923
(2)
CHEMBL1117924
(1)
|
0 / 0 |
compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
---|---|---|---|---|---|---|---|
C060311 | 207 |
AKT1
AKT CWS6 PKB PKB-ALPHA PRKBA RAC RAC-ALPHA |
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | eckol results in decreased phosphorylation of and results in decreased activity of AKT1 protein |
decreases activity
/ decreases phosphorylation |
protein |
21514314
|
C060311 | 841 |
CASP8
ALPS2B CAP4 Casp-8 FLICE MACH MCH5 |
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | [eckol co-treated with temozolomide] results in increased cleavage of CASP8 protein |
affects cotreatment
/ increases cleavage |
protein |
21514314
|
C060311 | 1499 |
CTNNB1
CTNNB MRD19 armadillo |
catenin (cadherin-associated protein), beta 1, 88kDa | eckol results in decreased expression of CTNNB1 protein |
decreases expression
|
protein |
21514314
|
C060311 | 1536 |
CYBB
AMCBX2 CGD GP91-1 GP91-PHOX GP91PHOX NOX2 p91-PHOX |
cytochrome b-245, beta polypeptide | eckol results in decreased expression of CYBB protein |
decreases expression
|
protein |
21514314
|
C060311 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | eckol results in decreased phosphorylation of and results in decreased activity of MAPK1 protein |
decreases activity
/ decreases phosphorylation |
protein |
21514314
|
C060311 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | eckol results in decreased phosphorylation of and results in decreased activity of MAPK3 protein |
decreases activity
/ decreases phosphorylation |
protein |
21514314
|
C060311 | 4440 |
MSI1
|
musashi RNA-binding protein 1 | eckol results in decreased expression of MSI1 protein |
decreases expression
|
protein |
21514314
|
C060311 | 10763 |
NES
|
nestin | eckol results in decreased expression of NES protein |
decreases expression
|
protein |
21514314
|
C060311 | 8842 |
PROM1
AC133 CD133 CORD12 MCDR2 PROML1 RP41 STGD4 |
prominin 1 | eckol results in decreased expression of PROM1 protein |
decreases expression
|
protein |
21514314
|
C060311 | 5894 |
RAF1
CRAF NS5 Raf-1 c-Raf |
v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) | eckol results in decreased activity of RAF1 protein |
decreases activity
|
protein |
21514314
|
C060311 | 6657 |
SOX2
ANOP3 MCOPS3 |
SRY (sex determining region Y)-box 2 | eckol results in decreased expression of SOX2 protein |
decreases expression
|
protein |
21514314
|