Metabolite

KNApSAcK Entry

id C00031757
Name Eckol
CAS RN 88798-74-7
Standard InChI InChI=1S/C18H12O9/c19-7-1-8(20)3-10(2-7)25-16-12(23)6-13(24)17-18(16)27-15-11(22)4-9(21)5-14(15)26-17/h1-6,19-24H
Standard InChI (Main Layer) InChI=1S/C18H12O9/c19-7-1-8(20)3-10(2-7)25-16-12(23)6-13(24)17-18(16)27-15-11(22)4-9(21)5-14(15)26-17/h1-6,19-24H

Cluster

Phytochemical cluster
KCF-S cluster No. 1893

Link

ChEMBL

By standard InChI CHEMBL471187
By standard InChI Main Layer CHEMBL471187

KEGG

By LinkDB

CTD

By CAS RN C060311

Species

Summary

Plant class

class name count

Family

family name count
Lessoniaceae 2

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Ecklonia stolonifera OKAMURA 105406 Lessoniaceae Eukaryota
Eisenia bicyclis 6395 Lessoniaceae Eukaryota

Human Protein / Gene in interaction

1 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P56817 Beta-secretase 1 A1A CHEMBL471187 CHEMBL1117923 (2) CHEMBL1117924 (1)
0 / 0

CTD interaction (11)

compound gene gene name gene description interaction interaction type form reference
pmid
C060311 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) eckol results in decreased phosphorylation of and results in decreased activity of AKT1 protein decreases activity
/ decreases phosphorylation
protein 21514314
C060311 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) [eckol co-treated with temozolomide] results in increased cleavage of CASP8 protein affects cotreatment
/ increases cleavage
protein 21514314
C060311 1499 CTNNB1
CTNNB
MRD19
armadillo
catenin (cadherin-associated protein), beta 1, 88kDa eckol results in decreased expression of CTNNB1 protein decreases expression
protein 21514314
C060311 1536 CYBB
AMCBX2
CGD
GP91-1
GP91-PHOX
GP91PHOX
NOX2
p91-PHOX
cytochrome b-245, beta polypeptide eckol results in decreased expression of CYBB protein decreases expression
protein 21514314
C060311 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) eckol results in decreased phosphorylation of and results in decreased activity of MAPK1 protein decreases activity
/ decreases phosphorylation
protein 21514314
C060311 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) eckol results in decreased phosphorylation of and results in decreased activity of MAPK3 protein decreases activity
/ decreases phosphorylation
protein 21514314
C060311 4440 MSI1
musashi RNA-binding protein 1 eckol results in decreased expression of MSI1 protein decreases expression
protein 21514314
C060311 10763 NES
nestin eckol results in decreased expression of NES protein decreases expression
protein 21514314
C060311 8842 PROM1
AC133
CD133
CORD12
MCDR2
PROML1
RP41
STGD4
prominin 1 eckol results in decreased expression of PROM1 protein decreases expression
protein 21514314
C060311 5894 RAF1
CRAF
NS5
Raf-1
c-Raf
v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) eckol results in decreased activity of RAF1 protein decreases activity
protein 21514314
C060311 6657 SOX2
ANOP3
MCOPS3
SRY (sex determining region Y)-box 2 eckol results in decreased expression of SOX2 protein decreases expression
protein 21514314