PCIDB

KNApSAcK Metabolite C00032053

Metabolite

KNApSAcK Entry

id C00032053
Name N,N-Dimethyladenine
CAS RN 938-55-6
Standard InChI InChI=1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11)
Standard InChI (Main Layer) InChI=1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11)

Cluster

Phytochemical cluster
KCF-S cluster No. 7706

Link

ChEMBL

By standard InChI CHEMBL407391
By standard InChI Main Layer CHEMBL407391

KEGG

By LinkDB

CTD

By CAS RN C001020

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Rosaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Spiraea formosana 409510 Rosaceae rosids Viridiplantae

Human Protein / Gene in interaction

18 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q14289 Protein-tyrosine kinase 2-beta Fak CHEMBL407391 CHEMBL2033180 (1)
0 / 0
O15530 3-phosphoinositide-dependent protein kinase 1 Pdk1 CHEMBL407391 CHEMBL1963821 (1)
0 / 0
Q05655 Protein kinase C delta type Delta CHEMBL407391 CHEMBL1963703 (1)
0 / 0
O14757 Serine/threonine-protein kinase Chk1 Chk1 CHEMBL407391 CHEMBL1963782 (1)
0 / 0
O14965 Aurora kinase A Aur CHEMBL407391 CHEMBL1963727 (1)
0 / 0
Q7KZI7 Serine/threonine-protein kinase MARK2 CAMK serine/threonine protein kinase MARK subfamily CHEMBL407391 CHEMBL1963834 (1)
0 / 0
P27448 MAP/microtubule affinity-regulating kinase 3 CAMK serine/threonine protein kinase MARK subfamily CHEMBL407391 CHEMBL1963756 (1)
0 / 0
P43403 Tyrosine-protein kinase ZAP-70 Syk CHEMBL407391 CHEMBL2033179 (1)
1 / 2
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL407391 CHEMBL2033178 (1)
0 / 0
P24864 G1/S-specific cyclin-E1 Other cytosolic protein CHEMBL407391 CHEMBL2033178 (1)
0 / 2
Q99683 Mitogen-activated protein kinase kinase kinase 5 Ste11 CHEMBL407391 CHEMBL1648129 (1)
0 / 0
P51812 Ribosomal protein S6 kinase alpha-3 Rskb CHEMBL407391 CHEMBL1963690 (1)
2 / 2
O96017 Serine/threonine-protein kinase Chk2 Rad53 CHEMBL407391 CHEMBL1963720 (1)
4 / 1
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka CHEMBL407391 CHEMBL1963835 (1)
0 / 0
Q9UBF8 Phosphatidylinositol 4-kinase beta Enzyme CHEMBL407391 CHEMBL758627 (1) CHEMBL758630 (1)
0 / 0
Q8TCG2 Phosphatidylinositol 4-kinase type 2-beta Enzyme CHEMBL407391 CHEMBL758627 (1) CHEMBL758630 (1)
0 / 0
Q9BTU6 Phosphatidylinositol 4-kinase type 2-alpha Enzyme CHEMBL407391 CHEMBL758627 (1) CHEMBL758630 (1)
0 / 0
P42356 Phosphatidylinositol 4-kinase alpha Enzyme CHEMBL407391 CHEMBL758627 (1) CHEMBL758630 (1)
0 / 0

CTD interaction (1)

compound gene gene name gene description interaction interaction type form reference
pmid
C001020 3978 LIG1
ligase I, DNA, ATP-dependent (EC:6.5.1.1) N(6),N(6)-dimethyladenine inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of LIG1 protein] decreases reaction
/ increases phosphorylation
protein 16700562

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (7)

OMIM preferred title UniProt
#114480 Breast cancer O96017
#303600 Coffin-lowry syndrome; cls P51812
#609265 Li-fraumeni syndrome 2; lfs2 O96017
#300844 Mental retardation, x-linked 19; mrx19 P51812
#259500 Osteogenic sarcoma O96017
#176807 Prostate cancer O96017
#269840 Selective t-cell defect; stcd P43403

KEGG DISEASE (7)

KEGG disease name UniProt
H00881 Li-Fraumeni syndrome O96017 (related)
H00018 Gastric cancer P24864 (related)
H00055 Laryngeal cancer P24864 (related)
H00093 Combined immunodeficiencies (CIDs) P43403 (related)
H00005 Chronic lymphocytic leukemia (CLL) P43403 (marker)
H00480 Non-syndromic X-linked mental retardation P51812 (related)
H00574 Coffin-Lowry syndrome (CLS) P51812 (related)