PCIDB

KNApSAcK Metabolite C00003375

Metabolite

KNApSAcK Entry

id C00003375
Name Thapsigargin
CAS RN 67526-95-8
Standard InChI InChI=1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1
Standard InChI (Main Layer) InChI=1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3

Cluster

Phytochemical cluster No. 38
KCF-S cluster No. 2100

Link

ChEMBL

By standard InChI CHEMBL96926
By standard InChI Main Layer CHEMBL96926 CHEMBL192566 CHEMBL1355952

KEGG

By LinkDB C09561

CTD

By CAS RN D019284

Species

Summary

Plant class

class name count
asterids 1

Family

family name count
Apiaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Thapsia garganica 79022 Apiaceae asterids Viridiplantae

Human Protein / Gene in interaction

45 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1355952 CHEMBL1614110 (1) CHEMBL1741321 (1)
1 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme CHEMBL96926 CHEMBL1614316 (1) CHEMBL1613805 (1)
CHEMBL1614009 (1) CHEMBL1614293 (1)
0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL1355952 CHEMBL1613992 (1) CHEMBL1613995 (1)
7 / 44
Q16637 Survival motor neuron protein Unclassified protein CHEMBL192566 CHEMBL1613842 (1)
4 / 2
Q99700 Ataxin-2 Unclassified protein CHEMBL96926 CHEMBL1794367 (1) CHEMBL2114784 (1)
1 / 1
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL96926 CHEMBL1738091 (1) CHEMBL1737859 (1)
CHEMBL1738565 (1)
0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL192566 CHEMBL1794573 (1)
2 / 2
P06746 DNA polymerase beta Enzyme CHEMBL192566 CHEMBL1614079 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL192566 CHEMBL1614378 (1)
1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL96926 CHEMBL1738600 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL192566 CHEMBL1614310 (1) CHEMBL1614544 (1)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL1355952 CHEMBL1614361 (1)
3 / 2
O14983 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Calcium CHEMBL96926 CHEMBL192566 CHEMBL828651 (3)
1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1355952 CHEMBL1614027 (1) CHEMBL1741325 (1)
0 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL192566 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL192566 CHEMBL1614458 (1)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL1355952 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL192566 CHEMBL1613941 (1)
0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL96926 CHEMBL1613838 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL192566 CHEMBL1794569 (1)
1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL96926 CHEMBL1738610 (1)
0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL96926 CHEMBL1794423 (1) CHEMBL1963893 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL96926 CHEMBL1794467 (1)
0 / 0
P06280 Alpha-galactosidase A Enzyme CHEMBL96926 CHEMBL192566 CHEMBL1614233 (1) CHEMBL1614369 (1)
1 / 1
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL192566 CHEMBL1614521 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1355952 CHEMBL1741322 (1)
0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL96926 CHEMBL192566 CHEMBL1614038 (2)
2 / 2
O15118 Niemann-Pick C1 protein Unclassified protein CHEMBL96926 CHEMBL1614342 (1)
1 / 1
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL192566 CHEMBL1614171 (1)
5 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL96926 CHEMBL1738675 (1) CHEMBL1737868 (1)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL1355952 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL1355952 CHEMBL1614240 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1355952 CHEMBL1613777 (1) CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1355952 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL192566 CHEMBL1794483 (1)
0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL192566 CHEMBL1614052 (1)
1 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL192566 CHEMBL1614283 (1) CHEMBL1614466 (1)
CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL96926 CHEMBL192566 CHEMBL1614250 (1) CHEMBL1614421 (4)
4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL192566 CHEMBL1738402 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL96926 CHEMBL1737980 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL96926 CHEMBL1794536 (4)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL1355952 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL96926 CHEMBL192566 CHEMBL1738442 (2)
0 / 0
O00255 Menin Unclassified protein CHEMBL192566 CHEMBL1614257 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL192566 CHEMBL1614257 (1)
1 / 3

CTD interaction (340)

compound gene gene name gene description interaction interaction type form reference
pmid
D019284 133 ADM
AM
adrenomedullin Thapsigargin results in decreased expression of ADM mRNA decreases expression
mRNA 20682585
D019284 150 ADRA2A
ADRA2
ADRA2R
ADRAR
ALPHA2AAR
ZNF32
adrenoceptor alpha 2A Thapsigargin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein] affects binding
/ decreases reaction
/ increases activity
protein 10742289
D019284 79026 AHNAK
AHNAKRS
AHNAK nucleoprotein Thapsigargin results in increased expression of AHNAK mRNA increases expression
mRNA 19442820
D019284 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 15339911
D019284 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Thapsigargin results in increased phosphorylation of AKT1 protein increases phosphorylation
protein 15339911
D019284 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) 1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein] decreases reaction
/ increases activity
/ increases localization
protein 18218859
D019284 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein]] decreases reaction
/ increases activity
/ increases localization
protein 18218859
D019284 240 ALOX5
5-LO
5-LOX
5LPG
LOG5
arachidonate 5-lipoxygenase (EC:1.13.11.34) Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein increases activity
/ increases localization
protein 18218859
D019284 467 ATF3
activating transcription factor 3 ATF3 mutant form promotes the reaction [Thapsigargin results in increased expression of PMAIP1 mRNA] increases expression
/ increases reaction
mutant form 20022965
D019284 467 ATF3
activating transcription factor 3 Thapsigargin results in increased expression of ATF3 mRNA increases expression
mRNA 17332266
21694771
22935518
D019284 467 ATF3
activating transcription factor 3 Thapsigargin results in increased expression of ATF3 protein increases expression
protein 20022965
D019284 468 ATF4
CREB-2
CREB2
TAXREB67
TXREB
activating transcription factor 4 ATF4 mutant form inhibits the reaction [Thapsigargin results in increased expression of PMAIP1 mRNA] decreases reaction
/ increases expression
mutant form 20022965
D019284 468 ATF4
CREB-2
CREB2
TAXREB67
TXREB
activating transcription factor 4 ATF4 mutant form inhibits the reaction [Thapsigargin results in increased expression of PMAIP1 protein] decreases reaction
/ increases expression
mutant form 20022965
D019284 468 ATF4
CREB-2
CREB2
TAXREB67
TXREB
activating transcription factor 4 ATF4 results in decreased susceptibility to Thapsigargin decreases response to substance
20022965
D019284 468 ATF4
CREB-2
CREB2
TAXREB67
TXREB
activating transcription factor 4 Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 mRNA] decreases reaction
/ increases expression
mRNA 20022965
D019284 468 ATF4
CREB-2
CREB2
TAXREB67
TXREB
activating transcription factor 4 Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein] decreases reaction
/ increases expression
protein 20022965
D019284 468 ATF4
CREB-2
CREB2
TAXREB67
TXREB
activating transcription factor 4 Doxorubicin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein] decreases reaction
/ increases expression
protein 16298333
D019284 468 ATF4
CREB-2
CREB2
TAXREB67
TXREB
activating transcription factor 4 NUPR1 mutant form promotes the reaction [Thapsigargin results in increased expression of ATF4 mRNA] increases expression
/ increases reaction
mRNA 20022965
D019284 468 ATF4
CREB-2
CREB2
TAXREB67
TXREB
activating transcription factor 4 Thapsigargin promotes the reaction [ATF4 protein binds to PMAIP1 promoter] affects binding
/ increases reaction
protein 20022965
D019284 468 ATF4
CREB-2
CREB2
TAXREB67
TXREB
activating transcription factor 4 Thapsigargin results in increased activity of ATF4 protein increases activity
protein 23383089
D019284 468 ATF4
CREB-2
CREB2
TAXREB67
TXREB
activating transcription factor 4 Thapsigargin results in increased expression of ATF4 mRNA increases expression
mRNA 16298333
17283163
20022965
D019284 468 ATF4
CREB-2
CREB2
TAXREB67
TXREB
activating transcription factor 4 Thapsigargin results in increased expression of ATF4 protein increases expression
protein 16298333
20022965
D019284 22926 ATF6
ATF6A
activating transcription factor 6 Thapsigargin results in increased activity of ATF6 protein increases activity
protein 23383089
D019284 488 ATP2A2
ATP2B
DAR
DD
SERCA2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (EC:3.6.3.8) ATP2A2 protein affects the susceptibility to Thapsigargin affects response to substance
protein 17475205
D019284 488 ATP2A2
ATP2B
DAR
DD
SERCA2
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (EC:3.6.3.8) Thapsigargin results in increased expression of ATP2A2 mRNA increases expression
mRNA 20816668
D019284 489 ATP2A3
SERCA3
ATPase, Ca++ transporting, ubiquitous (EC:3.6.3.8) [Thapsigargin co-treated with Ionomycin] promotes the reaction [STIM1 protein binds to ATP2A3 protein] affects binding
/ affects cotreatment
/ increases reaction
protein 18439569
D019284 245972 ATP6V0D2
ATP6D2
VMA6
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (EC:3.6.3.14) 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of ATP6V0D2 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 245972 ATP6V0D2
ATP6D2
VMA6
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (EC:3.6.3.14) caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ATP6V0D2 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 245972 ATP6V0D2
ATP6D2
VMA6
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (EC:3.6.3.14) Thapsigargin results in decreased expression of ATP6V0D2 mRNA decreases expression
mRNA 19442820
D019284 581 BAX
BCL2L4
BCL2-associated X protein Thapsigargin results in increased activity of BAX protein increases activity
protein 20130848
D019284 10282 BET1
HBET1
Bet1 golgi vesicular membrane trafficking protein [Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in decreased expression of BET1 mRNA affects cotreatment
/ decreases expression
mRNA 19442820
D019284 10282 BET1
HBET1
Bet1 golgi vesicular membrane trafficking protein Thapsigargin results in decreased expression of BET1 mRNA decreases expression
mRNA 19442820
D019284 329 BIRC2
API1
HIAP2
Hiap-2
MIHB
RNF48
c-IAP1
cIAP1
baculoviral IAP repeat containing 2 Thapsigargin results in decreased expression of BIRC2 protein decreases expression
protein 16382148
D019284 330 BIRC3
AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
baculoviral IAP repeat containing 3 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of BIRC3 mRNA] decreases reaction
/ increases expression
mRNA 15339911
D019284 330 BIRC3
AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
baculoviral IAP repeat containing 3 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of BIRC3 protein] decreases reaction
/ increases expression
protein 15339911
D019284 330 BIRC3
AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
baculoviral IAP repeat containing 3 Thapsigargin results in increased expression of BIRC3 mRNA increases expression
mRNA 15339911
D019284 330 BIRC3
AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
baculoviral IAP repeat containing 3 Thapsigargin results in increased expression of BIRC3 protein increases expression
protein 15339911
D019284 672 BRCA1
BRCAI
BRCC1
BROVCA1
IRIS
PNCA4
PPP1R53
PSCP
RNF53
breast cancer 1, early onset Thapsigargin results in increased expression of BRCA1 mRNA increases expression
mRNA 16434996
D019284 672 BRCA1
BRCAI
BRCC1
BROVCA1
IRIS
PNCA4
PPP1R53
PSCP
RNF53
breast cancer 1, early onset Thapsigargin results in increased expression of BRCA1 protein increases expression
protein 16434996
D019284 675 BRCA2
BRCC2
BROVCA2
FACD
FAD
FAD1
FANCB
FANCD
FANCD1
GLM3
PNCA2
breast cancer 2, early onset Thapsigargin results in increased expression of BRCA2 mRNA increases expression
mRNA 16434996
D019284 675 BRCA2
BRCC2
BROVCA2
FACD
FAD
FAD1
FANCB
FANCD
FANCD1
GLM3
PNCA2
breast cancer 2, early onset Thapsigargin results in increased expression of BRCA2 protein increases expression
protein 16434996
D019284 773 CACNA1A
APCA
BI
CACNL1A4
CAV2.1
EA2
FHM
HPCA
MHP
MHP1
SCA6
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit Thapsigargin results in increased expression of CACNA1A mRNA increases expression
mRNA 19442820
D019284 796 CALCA
CALC1
CGRP
CGRP-I
CGRP1
CT
KC
calcitonin-related polypeptide alpha Thapsigargin promotes the reaction [Lipopolysaccharides results in increased expression of CALCA mRNA] increases expression
/ increases reaction
mRNA 20682585
D019284 811 CALR
CRT
RO
SSA
cC1qR
calreticulin Thapsigargin results in increased expression of CALR protein increases expression
protein 17353921
D019284 813 CALU
calumenin Thapsigargin results in decreased expression of CALU mRNA decreases expression
mRNA 21692457
D019284 813 CALU
calumenin Thapsigargin results in decreased expression of CALU protein decreases expression
protein 21692457
D019284 821 CANX
CNX
IP90
P90
calnexin Thapsigargin results in increased expression of CANX protein increases expression
protein 17353921
D019284 100506742 CASP12
CASP-12
CASP12P1
caspase 12 (gene/pseudogene) tauroursodeoxycholic acid inhibits the reaction [Thapsigargin results in increased cleavage of CASP12 protein] decreases reaction
/ increases cleavage
protein 12198651
D019284 100506742 CASP12
CASP-12
CASP12P1
caspase 12 (gene/pseudogene) Thapsigargin results in increased cleavage of CASP12 protein increases cleavage
protein 12198651
D019284 835 CASP2
CASP-2
ICH1
NEDD-2
NEDD2
PPP1R57
caspase 2, apoptosis-related cysteine peptidase (EC:3.4.22.55) Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP2 protein] decreases reaction
/ increases activity
protein 16388830
D019284 835 CASP2
CASP-2
ICH1
NEDD-2
NEDD2
PPP1R57
caspase 2, apoptosis-related cysteine peptidase (EC:3.4.22.55) Thapsigargin results in increased activity of CASP2 protein increases activity
protein 16388830
D019284 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) bortezomib promotes the reaction [Thapsigargin results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 16357177
D019284 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Cyclosporine inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 12871656
D019284 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 16388830
D019284 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Melatonin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 20130848
D019284 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Tacrolimus inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 12871656
D019284 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) tauroursodeoxycholic acid inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 12198651
D019284 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Thapsigargin results in increased activity of CASP3 protein increases activity
protein 12198651
12871656
16357177
16388830
17559149
20022965
20130848
D019284 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Thapsigargin results in increased cleavage of CASP3 protein increases cleavage
protein 18178165
22800509
D019284 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Thapsigargin results in increased expression of CASP3 protein alternative form increases expression
protein 16382148
D019284 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Thapsigargin results in increased metabolism of CASP3 protein increases metabolic processing
protein 16382148
D019284 837 CASP4
ICE(rel)II
ICEREL-II
ICH-2
Mih1/TX
TX
caspase 4, apoptosis-related cysteine peptidase (EC:3.4.22.57) Thapsigargin results in increased cleavage of and results in increased activity of CASP4 protein increases activity
/ increases cleavage
protein 17559149
D019284 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Doxorubicin inhibits the reaction [Thapsigargin results in increased activity of and results in increased cleavage of CASP7 protein] decreases reaction
/ increases activity
/ increases cleavage
protein 16298333
D019284 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) tauroursodeoxycholic acid inhibits the reaction [Thapsigargin results in increased activity of CASP7 protein] decreases reaction
/ increases activity
protein 12198651
D019284 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Thapsigargin results in increased activity of and results in increased cleavage of CASP7 protein increases activity
/ increases cleavage
protein 16298333
D019284 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Thapsigargin results in increased activity of CASP7 protein increases activity
protein 12198651
17559149
19139269
20022965
D019284 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein] decreases reaction
/ increases activity
protein 16388830
D019284 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Melatonin inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein] decreases reaction
/ increases activity
protein 20130848
D019284 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Thapsigargin results in increased activity of CASP9 protein increases activity
protein 16388830
20130848
D019284 117155 CATSPER2
cation channel, sperm associated 2 Thapsigargin results in decreased expression of CATSPER2 mRNA decreases expression
mRNA 19442820
D019284 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Thapsigargin results in increased expression of CCL2 mRNA increases expression
mRNA 18951912
D019284 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Thapsigargin results in decreased expression of CCND1 mRNA decreases expression
mRNA 17332266
D019284 901 CCNG2
cyclin G2 Thapsigargin results in increased expression of CCNG2 mRNA increases expression
mRNA 17332266
D019284 991 CDC20
CDC20A
bA276H19.3
p55CDC
cell division cycle 20 [Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in increased expression of CDC20 mRNA affects cotreatment
/ increases expression
mRNA 19442820
D019284 991 CDC20
CDC20A
bA276H19.3
p55CDC
cell division cycle 20 [Thapsigargin co-treated with caffeic acid] results in increased expression of CDC20 mRNA affects cotreatment
/ increases expression
mRNA 19442820
D019284 991 CDC20
CDC20A
bA276H19.3
p55CDC
cell division cycle 20 [Thapsigargin co-treated with Drugs, Chinese Herbal] results in increased expression of CDC20 mRNA affects cotreatment
/ increases expression
mRNA 19442820
D019284 991 CDC20
CDC20A
bA276H19.3
p55CDC
cell division cycle 20 Thapsigargin results in increased expression of CDC20 mRNA increases expression
mRNA 19442820
D019284 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) caffeic acid promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 1017 CDK2
p33(CDK2)
cyclin-dependent kinase 2 (EC:2.7.11.22) Thapsigargin results in increased expression of CDK2 mRNA increases expression
mRNA 19442820
D019284 1063 CENPF
CENF
PRO1779
hcp-1
centromere protein F, 350/400kDa Thapsigargin results in increased expression of CENPF mRNA increases expression
mRNA 19442820
D019284 1080 CFTR
ABC35
ABCC7
CF
CFTR/MRP
MRP7
TNR-CFTR
dJ760C5.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) Thapsigargin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]] affects cotreatment
/ decreases reaction
/ increases reaction
/ increases transport
protein 18230692
D019284 1080 CFTR
ABC35
ABCC7
CF
CFTR/MRP
MRP7
TNR-CFTR
dJ760C5.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) Thapsigargin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium results in increased activity of CFTR protein mutant form] increases activity
/ increases reaction
protein 18230692
D019284 1080 CFTR
ABC35
ABCC7
CF
CFTR/MRP
MRP7
TNR-CFTR
dJ760C5.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) Thapsigargin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]] affects cotreatment
/ decreases reaction
/ increases reaction
/ increases transport
protein 18230692
D019284 1080 CFTR
ABC35
ABCC7
CF
CFTR/MRP
MRP7
TNR-CFTR
dJ760C5.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) Thapsigargin promotes the reaction [miglustat results in increased activity of CFTR protein mutant form] increases activity
/ increases reaction
protein 18230692
D019284 1081 CGA
CG-ALPHA
FSHA
GPHA1
GPHa
HCG
LHA
TSHA
glycoprotein hormones, alpha polypeptide Thapsigargin results in increased expression of CGA mRNA increases expression
mRNA 21694771
D019284 79094 CHAC1
ChaC, cation transport regulator homolog 1 (E. coli) Thapsigargin results in decreased expression of CHAC1 mRNA decreases expression
mRNA 19442820
D019284 10036 CHAF1A
CAF-1
CAF1
CAF1B
CAF1P150
P150
chromatin assembly factor 1, subunit A (p150) Thapsigargin results in increased expression of CHAF1A mRNA increases expression
mRNA 19442820
D019284 1152 CKB
B-CK
CKBB
creatine kinase, brain (EC:2.7.3.2) Thapsigargin results in decreased expression of CKB protein decreases expression
protein 21692457
D019284 6320 CLEC11A
CLECSF3
LSLCL
P47
SCGF
C-type lectin domain family 11, member A Thapsigargin results in increased expression of CLEC11A mRNA increases expression
mRNA 19442820
D019284 1293 COL6A3
collagen, type VI, alpha 3 Thapsigargin promotes the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone] increases reaction
/ increases response to substance
gene 18435905
D019284 51138 COPS4
CSN4
COP9 signalosome subunit 4 Thapsigargin results in decreased expression of COPS4 protein decreases expression
protein 21692457
D019284 8904 CPNE1
COPN1
CPN1
copine I Thapsigargin results in decreased expression of CPNE1 protein decreases expression
protein 21692457
D019284 90993 CREB3L1
OASIS
cAMP responsive element binding protein 3-like 1 Thapsigargin results in increased activity of CREB3L1 protein increases activity
protein 23383089
D019284 90993 CREB3L1
OASIS
cAMP responsive element binding protein 3-like 1 [Thapsigargin results in increased activity of CREB3L1 protein] which results in increased expression of VEGFA mRNA increases activity
/ increases expression
protein 23383089
D019284 1429 CRYZ
crystallin, zeta (quinone reductase) (EC:1.6.5.5) Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of CRYZ mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 1429 CRYZ
crystallin, zeta (quinone reductase) (EC:1.6.5.5) Thapsigargin results in increased expression of CRYZ mRNA increases expression
mRNA 19442820
D019284 1489 CTF1
CT-1
CT1
cardiotrophin 1 caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CTF1 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 1489 CTF1
CT-1
CT1
cardiotrophin 1 Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of CTF1 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 1489 CTF1
CT-1
CT1
cardiotrophin 1 [Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in decreased expression of CTF1 mRNA affects cotreatment
/ decreases expression
mRNA 19442820
D019284 2920 CXCL2
CINC-2a
GRO2
GROb
MGSA-b
MIP-2a
MIP2
MIP2A
SCYB2
chemokine (C-X-C motif) ligand 2 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 2920 CXCL2
CINC-2a
GRO2
GROb
MGSA-b
MIP-2a
MIP2
MIP2A
SCYB2
chemokine (C-X-C motif) ligand 2 caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 2920 CXCL2
CINC-2a
GRO2
GROb
MGSA-b
MIP-2a
MIP2
MIP2A
SCYB2
chemokine (C-X-C motif) ligand 2 Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 4051 CYP4F3
CPF3
CYP4F
LTB4H
cytochrome P450, family 4, subfamily F, polypeptide 3 (EC:1.14.13.30) Thapsigargin results in decreased expression of CYP4F3 mRNA decreases expression
mRNA 19442820
D019284 1611 DAP
death-associated protein 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 1611 DAP
death-associated protein caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 1611 DAP
death-associated protein Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 DDIT3 results in decreased susceptibility to Thapsigargin decreases response to substance
20022965
D019284 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 Doxorubicin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein] decreases reaction
/ increases expression
protein 16298333
D019284 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 Quercetin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 mRNA] decreases reaction
/ increases expression
mRNA 19428936
D019284 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 Thapsigargin promotes the reaction [DDIT3 protein binds to LCN2 promoter] affects binding
/ increases reaction
protein 22800509
D019284 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 Thapsigargin results in increased activity of DDIT3 protein increases activity
protein 19139269
D019284 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 Thapsigargin results in increased expression of and affects the localization of DDIT3 protein affects localization
/ increases expression
protein 22800509
D019284 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 Thapsigargin results in increased expression of DDIT3 mRNA increases expression
mRNA 17283163
17332266
19135031
19428936
21694771
22800509
22935518
D019284 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 Thapsigargin results in increased expression of DDIT3 protein increases expression
protein 16298333
17353921
20626587
21525004
D019284 56616 DIABLO
DFNA64
SMAC
diablo, IAP-binding mitochondrial protein DIABLO protein affects the susceptibility to Thapsigargin affects response to substance
protein 16382148
D019284 56616 DIABLO
DFNA64
SMAC
diablo, IAP-binding mitochondrial protein Thapsigargin affects the localization of DIABLO protein affects localization
protein 15339911
D019284 51726 DNAJB11
ABBP-2
ABBP2
DJ9
Dj-9
EDJ
ERdj3
ERj3
ERj3p
PRO1080
UNQ537
hDj-9
DnaJ (Hsp40) homolog, subfamily B, member 11 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 51726 DNAJB11
ABBP-2
ABBP2
DJ9
Dj-9
EDJ
ERdj3
ERj3
ERj3p
PRO1080
UNQ537
hDj-9
DnaJ (Hsp40) homolog, subfamily B, member 11 caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 51726 DNAJB11
ABBP-2
ABBP2
DJ9
Dj-9
EDJ
ERdj3
ERj3
ERj3p
PRO1080
UNQ537
hDj-9
DnaJ (Hsp40) homolog, subfamily B, member 11 Thapsigargin results in decreased expression of DNAJB11 mRNA decreases expression
mRNA 19442820
D019284 4189 DNAJB9
ERdj4
MDG-1
MDG1
MST049
MSTP049
DnaJ (Hsp40) homolog, subfamily B, member 9 Thapsigargin results in increased expression of DNAJB9 mRNA increases expression
mRNA 19135031
D019284 54431 DNAJC10
ERdj5
JPDI
MTHr
PDIA19
DnaJ (Hsp40) homolog, subfamily C, member 10 Thapsigargin results in increased expression of DNAJC10 mRNA increases expression
mRNA 17353921
D019284 5611 DNAJC3
ERdj6
HP58
P58
P58IPK
PRKRI
DnaJ (Hsp40) homolog, subfamily C, member 3 Thapsigargin results in increased expression of DNAJC3 mRNA increases expression
mRNA 19135031
D019284 10570 DPYSL4
CRMP3
DRP-4
ULIP4
dihydropyrimidinase-like 4 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 10570 DPYSL4
CRMP3
DRP-4
ULIP4
dihydropyrimidinase-like 4 caffeic acid promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 10570 DPYSL4
CRMP3
DRP-4
ULIP4
dihydropyrimidinase-like 4 Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 10570 DPYSL4
CRMP3
DRP-4
ULIP4
dihydropyrimidinase-like 4 Thapsigargin results in increased expression of DPYSL4 mRNA increases expression
mRNA 19442820
D019284 1950 EGF
HOMG4
URG
epidermal growth factor Thapsigargin inhibits the reaction [EGF protein affects the localization of PRKCB protein] affects localization
/ decreases reaction
protein 17991733
D019284 1958 EGR1
AT225
G0S30
KROX-24
NGFI-A
TIS8
ZIF-268
ZNF225
early growth response 1 Thapsigargin results in increased expression of EGR1 mRNA increases expression
mRNA 21694771
D019284 83939 EIF2A
EIF-2A
MST089
MSTP004
MSTP089
eukaryotic translation initiation factor 2A, 65kDa Doxorubicin promotes the reaction [Thapsigargin results in increased phosphorylation of EIF2A protein] increases phosphorylation
/ increases reaction
protein 16298333
D019284 83939 EIF2A
EIF-2A
MST089
MSTP004
MSTP089
eukaryotic translation initiation factor 2A, 65kDa Thapsigargin results in increased phosphorylation of EIF2A protein increases phosphorylation
protein 16298333
17353921
19428936
D019284 9451 EIF2AK3
PEK
PERK
WRS
eukaryotic translation initiation factor 2-alpha kinase 3 (EC:2.7.11.1) EIF2AK3 mutant form inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein] decreases reaction
/ increases phosphorylation
mutant form 20022965
D019284 1965 EIF2S1
EIF-2
EIF-2A
EIF-2alpha
EIF2
EIF2A
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa EIF2AK3 mutant form inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein] decreases reaction
/ increases phosphorylation
protein 20022965
D019284 1965 EIF2S1
EIF-2
EIF-2A
EIF-2alpha
EIF2
EIF2A
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa Thapsigargin results in increased phosphorylation of EIF2S1 protein increases phosphorylation
protein 17553788
19233273
20022965
D019284 8668 EIF3I
EIF3S2
PRO2242
TRIP-1
TRIP1
eIF3-beta
eIF3-p36
eukaryotic translation initiation factor 3, subunit I Thapsigargin results in decreased expression of EIF3I protein decreases expression
protein 21692457
D019284 1984 EIF5A
EIF-5A
EIF5A1
eIF5AI
eukaryotic translation initiation factor 5A EIF5A protein affects the susceptibility to Thapsigargin affects response to substance
protein 20376341
D019284 63916 ELMO2
CED-12
CED12
ELMO-2
engulfment and cell motility 2 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of ELMO2 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 63916 ELMO2
CED-12
CED12
ELMO-2
engulfment and cell motility 2 caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ELMO2 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 63916 ELMO2
CED-12
CED12
ELMO-2
engulfment and cell motility 2 Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of ELMO2 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 2077 ERF
CRS4
PE-2
PE2
Ets2 repressor factor caffeic acid promotes the reaction [Thapsigargin results in increased expression of ERF mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 2077 ERF
CRS4
PE-2
PE2
Ets2 repressor factor Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of ERF mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 2077 ERF
CRS4
PE-2
PE2
Ets2 repressor factor Thapsigargin results in increased expression of ERF mRNA increases expression
mRNA 19442820
D019284 2081 ERN1
IRE1
IRE1P
IRE1a
hIRE1p
endoplasmic reticulum to nucleus signaling 1 (EC:2.7.11.1) Thapsigargin results in increased expression of ERN1 protein increases expression
protein 19139269
D019284 2258 FGF13
FGF-13
FGF2
FHF-2
FHF2
fibroblast growth factor 13 Thapsigargin results in decreased expression of FGF13 mRNA decreases expression
mRNA 19442820
D019284 23768 FLRT2
fibronectin leucine rich transmembrane protein 2 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of FLRT2 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 23768 FLRT2
fibronectin leucine rich transmembrane protein 2 caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLRT2 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 23768 FLRT2
fibronectin leucine rich transmembrane protein 2 Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of FLRT2 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 23768 FLRT2
fibronectin leucine rich transmembrane protein 2 Thapsigargin results in decreased expression of FLRT2 mRNA decreases expression
mRNA 19442820
D019284 2324 FLT4
FLT41
LMPH1A
PCL
VEGFR3
fms-related tyrosine kinase 4 (EC:2.7.10.1) 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of FLT4 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 2324 FLT4
FLT41
LMPH1A
PCL
VEGFR3
fms-related tyrosine kinase 4 (EC:2.7.10.1) caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLT4 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 2324 FLT4
FLT41
LMPH1A
PCL
VEGFR3
fms-related tyrosine kinase 4 (EC:2.7.10.1) Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of FLT4 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Thapsigargin results in increased expression of FOS mRNA increases expression
mRNA 21694771
D019284 2354 FOSB
AP-1
G0S3
GOS3
GOSB
FBJ murine osteosarcoma viral oncogene homolog B Thapsigargin results in increased expression of FOSB mRNA increases expression
mRNA 21694771
D019284 1647 GADD45A
DDIT1
GADD45
growth arrest and DNA-damage-inducible, alpha Thapsigargin results in increased expression of GADD45A mRNA increases expression
mRNA 17332266
D019284 2669 GEM
KIR
GTP binding protein overexpressed in skeletal muscle Thapsigargin results in increased expression of GEM mRNA increases expression
mRNA 21694771
D019284 9527 GOSR1
GOLIM2
GOS-28
GOS28
GOS28/P28
GS28
P28
golgi SNAP receptor complex member 1 Thapsigargin results in decreased expression of GOSR1 mRNA decreases expression
mRNA 19442820
D019284 2936 GSR
glutathione reductase (EC:1.8.1.7) 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of GSR mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 2936 GSR
glutathione reductase (EC:1.8.1.7) caffeic acid promotes the reaction [Thapsigargin results in decreased expression of GSR mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 2936 GSR
glutathione reductase (EC:1.8.1.7) Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of GSR mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 2936 GSR
glutathione reductase (EC:1.8.1.7) Thapsigargin results in decreased expression of GSR mRNA decreases expression
mRNA 19442820
D019284 3014 H2AFX
H2A.X
H2A/X
H2AX
H2A histone family, member X Thapsigargin results in increased expression of H2AFX mRNA increases expression
mRNA 19442820
D019284 3068 HDGF
HMG1L2
hepatoma-derived growth factor Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of HDGF mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 3068 HDGF
HMG1L2
hepatoma-derived growth factor Thapsigargin results in increased expression of HDGF mRNA increases expression
mRNA 19442820
D019284 3099 HK2
HKII
HXK2
hexokinase 2 (EC:2.7.1.1) Thapsigargin results in increased expression of HK2 mRNA increases expression
mRNA 21694771
D019284 7184 HSP90B1
ECGP
GP96
GRP94
TRA1
heat shock protein 90kDa beta (Grp94), member 1 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 7184 HSP90B1
ECGP
GP96
GRP94
TRA1
heat shock protein 90kDa beta (Grp94), member 1 caffeic acid promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 7184 HSP90B1
ECGP
GP96
GRP94
TRA1
heat shock protein 90kDa beta (Grp94), member 1 Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 7184 HSP90B1
ECGP
GP96
GRP94
TRA1
heat shock protein 90kDa beta (Grp94), member 1 Thapsigargin results in decreased expression of HSP90B1 mRNA decreases expression
mRNA 19442820
D019284 7184 HSP90B1
ECGP
GP96
GRP94
TRA1
heat shock protein 90kDa beta (Grp94), member 1 Thapsigargin results in increased expression of HSP90B1 mRNA increases expression
mRNA 15292203
D019284 7184 HSP90B1
ECGP
GP96
GRP94
TRA1
heat shock protein 90kDa beta (Grp94), member 1 Thapsigargin results in increased expression of HSP90B1 protein increases expression
protein 17416481
D019284 3309 HSPA5
BIP
GRP78
MIF2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA] decreases reaction
/ increases expression
mRNA 19428936
D019284 3309 HSPA5
BIP
GRP78
MIF2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Doxorubicin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein] decreases reaction
/ increases expression
protein 16298333
D019284 3309 HSPA5
BIP
GRP78
MIF2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Quercetin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA] decreases reaction
/ increases expression
mRNA 19428936
D019284 3309 HSPA5
BIP
GRP78
MIF2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Quercetin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein] decreases reaction
/ increases expression
protein 19428936
D019284 3309 HSPA5
BIP
GRP78
MIF2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) tauroursodeoxycholic acid inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein] decreases reaction
/ increases expression
protein 12198651
D019284 3309 HSPA5
BIP
GRP78
MIF2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Thapsigargin results in increased expression of HSPA5 mRNA increases expression
mRNA 12147617
17283163
17332266
19135031
19428936
21320468
21692457
21694771
22800509
D019284 3309 HSPA5
BIP
GRP78
MIF2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Thapsigargin results in increased expression of HSPA5 protein increases expression
protein 12198651
16298333
17353921
17416481
17915553
19139269
19428936
20626587
21320468
21692457
D019284 3309 HSPA5
BIP
GRP78
MIF2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) wortmannin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA] decreases reaction
/ increases expression
mRNA 19428936
D019284 3313 HSPA9
CSA
GRP-75
GRP75
HSPA9B
MOT
MOT2
MTHSP75
PBP74
heat shock 70kDa protein 9 (mortalin) Thapsigargin results in decreased expression of HSPA9 protein decreases expression
protein 21692457
D019284 3336 HSPE1
CPN10
EPF
GROES
HSP10
heat shock 10kDa protein 1 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in increased expression of HSPE1 mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 3336 HSPE1
CPN10
EPF
GROES
HSP10
heat shock 10kDa protein 1 caffeic acid promotes the reaction [Thapsigargin results in increased expression of HSPE1 mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 3336 HSPE1
CPN10
EPF
GROES
HSP10
heat shock 10kDa protein 1 Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of HSPE1 mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 3336 HSPE1
CPN10
EPF
GROES
HSP10
heat shock 10kDa protein 1 Thapsigargin results in increased expression of HSPE1 mRNA increases expression
mRNA 19442820
D019284 3350 HTR1A
5-HT-1A
5-HT1A
5HT1a
ADRB2RL1
ADRBRL1
G-21
PFMCD
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled Thapsigargin results in increased activity of HTR1A protein increases activity
protein 11356925
D019284 50615 IL21R
CD360
NILR
interleukin 21 receptor 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of IL21R mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 50615 IL21R
CD360
NILR
interleukin 21 receptor caffeic acid promotes the reaction [Thapsigargin results in decreased expression of IL21R mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 50615 IL21R
CD360
NILR
interleukin 21 receptor Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of IL21R mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Thapsigargin promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] increases expression
/ increases reaction
mRNA 20682585
D019284 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Thapsigargin results in increased expression of IL6 mRNA increases expression
mRNA 18951912
21694771
D019284 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Thapsigargin results in increased expression of IL8 mRNA increases expression
mRNA 18951912
D019284 3624 INHBA
EDF
FRP
inhibin, beta A Thapsigargin results in increased expression of INHBA mRNA increases expression
mRNA 21694771
D019284 83729 INHBE
inhibin, beta E Thapsigargin results in increased expression of INHBE mRNA increases expression
mRNA 22935518
D019284 3783 KCNN4
IK1
IKCA1
KCA4
KCa3.1
SK4
hIKCa1
hKCa4
hSK4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 Thapsigargin results in increased expression of KCNN4 mRNA increases expression
mRNA 19442820
D019284 115207 KCTD12
C13orf2
PFET1
PFETIN
potassium channel tetramerization domain containing 12 Thapsigargin results in increased expression of KCTD12 mRNA increases expression
mRNA 19442820
D019284 56992 KIF15
HKLP2
KNSL7
NY-BR-62
kinesin family member 15 [Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in increased expression of KIF15 mRNA affects cotreatment
/ increases expression
mRNA 19442820
D019284 56992 KIF15
HKLP2
KNSL7
NY-BR-62
kinesin family member 15 [Thapsigargin co-treated with caffeic acid] results in increased expression of KIF15 mRNA affects cotreatment
/ increases expression
mRNA 19442820
D019284 56992 KIF15
HKLP2
KNSL7
NY-BR-62
kinesin family member 15 [Thapsigargin co-treated with Drugs, Chinese Herbal] results in increased expression of KIF15 mRNA affects cotreatment
/ increases expression
mRNA 19442820
D019284 56992 KIF15
HKLP2
KNSL7
NY-BR-62
kinesin family member 15 Thapsigargin results in increased expression of KIF15 mRNA increases expression
mRNA 19442820
D019284 9585 KIF20B
CT90
KRMP1
MPHOSPH1
MPP-1
MPP1
kinesin family member 20B 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in increased expression of KIF20B mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 9585 KIF20B
CT90
KRMP1
MPHOSPH1
MPP-1
MPP1
kinesin family member 20B caffeic acid promotes the reaction [Thapsigargin results in increased expression of KIF20B mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 9585 KIF20B
CT90
KRMP1
MPHOSPH1
MPP-1
MPP1
kinesin family member 20B Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of KIF20B mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 9585 KIF20B
CT90
KRMP1
MPHOSPH1
MPP-1
MPP1
kinesin family member 20B Thapsigargin results in increased expression of KIF20B mRNA increases expression
mRNA 19442820
D019284 11004 KIF2C
KNSL6
MCAK
kinesin family member 2C 4-methoxycinnamate methyl ester inhibits the reaction [Thapsigargin results in increased expression of KIF2C mRNA] decreases reaction
/ increases expression
mRNA 19442820
D019284 11004 KIF2C
KNSL6
MCAK
kinesin family member 2C caffeic acid inhibits the reaction [Thapsigargin results in increased expression of KIF2C mRNA] decreases reaction
/ increases expression
mRNA 19442820
D019284 11004 KIF2C
KNSL6
MCAK
kinesin family member 2C Drugs, Chinese Herbal inhibits the reaction [Thapsigargin results in increased expression of KIF2C mRNA] decreases reaction
/ increases expression
mRNA 19442820
D019284 11004 KIF2C
KNSL6
MCAK
kinesin family member 2C Thapsigargin results in increased expression of KIF2C mRNA increases expression
mRNA 19442820
D019284 3853 KRT6A
CK6A
CK6C
CK6D
K6A
K6C
K6D
KRT6C
KRT6D
keratin 6A Thapsigargin results in decreased expression of KRT6A protein decreases expression
protein 21692457
D019284 3856 KRT8
CARD2
CK-8
CK8
CYK8
K2C8
K8
KO
keratin 8 Thapsigargin results in decreased expression of KRT8 protein decreases expression
protein 21692457
D019284 3934 LCN2
24p3
MSFI
NGAL
lipocalin 2 Thapsigargin promotes the reaction [DDIT3 protein binds to LCN2 promoter] affects binding
/ increases reaction
promoter 22800509
D019284 3934 LCN2
24p3
MSFI
NGAL
lipocalin 2 Thapsigargin results in increased expression of and results in increased secretion of LCN2 protein increases expression
/ increases secretion
protein 22800509
D019284 3934 LCN2
24p3
MSFI
NGAL
lipocalin 2 Thapsigargin results in increased expression of LCN2 mRNA increases expression
mRNA 22800509
D019284 3998 LMAN1
ERGIC-53
ERGIC53
F5F8D
FMFD1
MCFD1
MR60
gp58
lectin, mannose-binding, 1 Thapsigargin results in increased expression of LMAN1 mRNA increases expression
mRNA 15292203
D019284 4069 LYZ
LZM
lysozyme (EC:3.2.1.17) [Thapsigargin co-treated with Colforsin] results in increased secretion of LYZ protein affects cotreatment
/ increases secretion
protein 15234967
D019284 4069 LYZ
LZM
lysozyme (EC:3.2.1.17) Thapsigargin results in increased secretion of LYZ protein increases secretion
protein 15234967
D019284 23499 MACF1
ABP620
ACF7
MACF
OFC4
microtubule-actin crosslinking factor 1 Thapsigargin results in increased expression of MACF1 mRNA increases expression
mRNA 19442820
D019284 5607 MAP2K5
HsT17454
MAPKK5
MEK5
PRKMK5
mitogen-activated protein kinase kinase 5 (EC:2.7.12.2) [Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in decreased expression of MAP2K5 mRNA affects cotreatment
/ decreases expression
mRNA 19442820
D019284 5607 MAP2K5
HsT17454
MAPKK5
MEK5
PRKMK5
mitogen-activated protein kinase kinase 5 (EC:2.7.12.2) [Thapsigargin co-treated with caffeic acid] results in decreased expression of MAP2K5 mRNA affects cotreatment
/ decreases expression
mRNA 19442820
D019284 5607 MAP2K5
HsT17454
MAPKK5
MEK5
PRKMK5
mitogen-activated protein kinase kinase 5 (EC:2.7.12.2) [Thapsigargin co-treated with Drugs, Chinese Herbal] results in decreased expression of MAP2K5 mRNA affects cotreatment
/ decreases expression
mRNA 19442820
D019284 5607 MAP2K5
HsT17454
MAPKK5
MEK5
PRKMK5
mitogen-activated protein kinase kinase 5 (EC:2.7.12.2) Thapsigargin results in decreased expression of MAP2K5 mRNA decreases expression
mRNA 19442820
D019284 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Genistein] inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]] affects cotreatment
/ decreases reaction
/ increases phosphorylation
/ increases reaction
protein 16251475
D019284 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 15339911
D019284 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Genistein inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]] decreases reaction
/ increases phosphorylation
/ increases reaction
protein 16251475
D019284 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein] increases phosphorylation
/ increases reaction
protein 16251475
D019284 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Thapsigargin results in increased phosphorylation of MAPK1 protein increases phosphorylation
protein 15339911
20850495
D019284 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Genistein] inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]] affects cotreatment
/ decreases reaction
/ increases phosphorylation
/ increases reaction
protein 16251475
D019284 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 15339911
D019284 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Genistein inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]] decreases reaction
/ increases phosphorylation
/ increases reaction
protein 16251475
D019284 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein] increases phosphorylation
/ increases reaction
protein 16251475
D019284 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Thapsigargin results in increased phosphorylation of MAPK3 protein increases phosphorylation
protein 15339911
20850495
D019284 4149 MAX
bHLHd4
MYC associated factor X 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of MAX mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 4149 MAX
bHLHd4
MYC associated factor X Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of MAX mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 4149 MAX
bHLHd4
MYC associated factor X Thapsigargin results in decreased expression of MAX mRNA decreases expression
mRNA 19442820
D019284 4170 MCL1
BCL2L3
EAT
MCL1-ES
MCL1L
MCL1S
Mcl-1
TM
bcl2-L-3
mcl1/EAT
myeloid cell leukemia sequence 1 (BCL2-related) Thapsigargin results in increased expression of MCL1 mRNA increases expression
mRNA 17553788
D019284 4176 MCM7
CDC47
MCM2
P1.1-MCM3
P1CDC47
P85MCM
PNAS146
minichromosome maintenance complex component 7 (EC:3.6.4.12) Thapsigargin results in increased expression of MCM7 mRNA increases expression
mRNA 19442820
D019284 55669 MFN1
hfzo1
hfzo2
mitofusin 1 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of MFN1 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 55669 MFN1
hfzo1
hfzo2
mitofusin 1 caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MFN1 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 55669 MFN1
hfzo1
hfzo2
mitofusin 1 Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of MFN1 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 84311 MRPL45
L45mt
MRP-L45
mitochondrial ribosomal protein L45 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of MRPL45 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 84311 MRPL45
L45mt
MRP-L45
mitochondrial ribosomal protein L45 caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MRPL45 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 84311 MRPL45
L45mt
MRP-L45
mitochondrial ribosomal protein L45 Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of MRPL45 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 92399 MRRF
MRFF
MTRRF
RRF
mitochondrial ribosome recycling factor 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of MRRF mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 92399 MRRF
MRFF
MTRRF
RRF
mitochondrial ribosome recycling factor caffeic acid promotes the reaction [Thapsigargin results in decreased expression of MRRF mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 92399 MRRF
MRFF
MTRRF
RRF
mitochondrial ribosome recycling factor Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of MRRF mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 4489 MT1A
MT1
MT1S
MTC
metallothionein 1A Thapsigargin results in increased expression of MT1A mRNA increases expression
mRNA 21694771
D019284 4609 MYC
MRTL
MYCC
bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog Thapsigargin results in decreased expression of MYC protein decreases expression
protein 20022965
D019284 4666 NACA
NACA1
nascent polypeptide-associated complex alpha subunit (EC:5.3.99.3) Thapsigargin results in decreased expression of NACA protein decreases expression
protein 21692457
D019284 4772 NFATC1
NF-ATC
NFAT2
NFATc
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 Thapsigargin promotes the reaction [PPP3CA protein results in decreased phosphorylation of NFATC1 protein] decreases phosphorylation
/ increases reaction
protein 10898953
D019284 4780 NFE2L2
NRF2
nuclear factor, erythroid 2-like 2 Thapsigargin inhibits the reaction [sodium arsenite results in increased activity of NFE2L2 protein] decreases reaction
/ increases activity
protein 20805060
D019284 4929 NR4A2
HZF-3
NOT
NURR1
RNR1
TINUR
nuclear receptor subfamily 4, group A, member 2 Thapsigargin results in increased expression of NR4A2 mRNA increases expression
mRNA 21694771
D019284 26471 NUPR1
COM1
P8
nuclear protein, transcriptional regulator, 1 NUPR1 mutant form promotes the reaction [Thapsigargin results in increased expression of ATF4 mRNA] increases expression
/ increases reaction
mutant form 20022965
D019284 26471 NUPR1
COM1
P8
nuclear protein, transcriptional regulator, 1 Thapsigargin results in increased expression of NUPR1 mRNA increases expression
mRNA 20022965
D019284 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) [orlistat co-treated with Thapsigargin] results in increased cleavage of PARP1 protein affects cotreatment
/ increases cleavage
protein 17283163
D019284 5106 PCK2
PEPCK
PEPCK-M
PEPCK2
phosphoenolpyruvate carboxykinase 2 (mitochondrial) (EC:4.1.1.32) Thapsigargin results in increased expression of PCK2 mRNA increases expression
mRNA 21694771
D019284 11235 PDCD10
CCM3
TFAR15
programmed cell death 10 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of PDCD10 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 11235 PDCD10
CCM3
TFAR15
programmed cell death 10 caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PDCD10 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 11235 PDCD10
CCM3
TFAR15
programmed cell death 10 Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of PDCD10 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 10015 PDCD6IP
AIP1
ALIX
DRIP4
HP95
programmed cell death 6 interacting protein Thapsigargin results in increased expression of PDCD6IP mRNA increases expression
mRNA 21692457
D019284 10015 PDCD6IP
AIP1
ALIX
DRIP4
HP95
programmed cell death 6 interacting protein Thapsigargin results in increased expression of PDCD6IP protein increases expression
protein 21692457
D019284 2923 PDIA3
ER60
ERp57
ERp60
ERp61
GRP57
GRP58
HsT17083
P58
PI-PLC
protein disulfide isomerase family A, member 3 (EC:5.3.4.1) Thapsigargin results in increased expression of PDIA3 mRNA increases expression
mRNA 17353921
D019284 2923 PDIA3
ER60
ERp57
ERp60
ERp61
GRP57
GRP58
HsT17083
P58
PI-PLC
protein disulfide isomerase family A, member 3 (EC:5.3.4.1) Thapsigargin results in increased expression of PDIA3 protein increases expression
protein 17353921
D019284 5187 PER1
PER
RIGUI
hPER
period circadian clock 1 Thapsigargin results in increased expression of PER1 mRNA increases expression
mRNA 21694771
D019284 5347 PLK1
PLK
STPK13
polo-like kinase 1 (EC:2.7.11.21) [Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in increased expression of PLK1 mRNA affects cotreatment
/ increases expression
mRNA 19442820
D019284 5347 PLK1
PLK
STPK13
polo-like kinase 1 (EC:2.7.11.21) [Thapsigargin co-treated with caffeic acid] results in increased expression of PLK1 mRNA affects cotreatment
/ increases expression
mRNA 19442820
D019284 5347 PLK1
PLK
STPK13
polo-like kinase 1 (EC:2.7.11.21) [Thapsigargin co-treated with Drugs, Chinese Herbal] results in increased expression of PLK1 mRNA affects cotreatment
/ increases expression
mRNA 19442820
D019284 5347 PLK1
PLK
STPK13
polo-like kinase 1 (EC:2.7.11.21) Thapsigargin results in increased expression of PLK1 mRNA increases expression
mRNA 19442820
D019284 10733 PLK4
SAK
STK18
polo-like kinase 4 (EC:2.7.11.21) 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in increased expression of PLK4 mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 10733 PLK4
SAK
STK18
polo-like kinase 4 (EC:2.7.11.21) caffeic acid promotes the reaction [Thapsigargin results in increased expression of PLK4 mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 10733 PLK4
SAK
STK18
polo-like kinase 4 (EC:2.7.11.21) Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of PLK4 mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 10733 PLK4
SAK
STK18
polo-like kinase 4 (EC:2.7.11.21) Thapsigargin results in increased expression of PLK4 mRNA increases expression
mRNA 19442820
D019284 8985 PLOD3
LH3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4) Thapsigargin results in decreased expression of PLOD3 protein decreases expression
protein 21692457
D019284 5366 PMAIP1
APR
NOXA
phorbol-12-myristate-13-acetate-induced protein 1 ATF3 mutant form promotes the reaction [Thapsigargin results in increased expression of PMAIP1 mRNA] increases expression
/ increases reaction
mRNA 20022965
D019284 5366 PMAIP1
APR
NOXA
phorbol-12-myristate-13-acetate-induced protein 1 ATF4 mutant form inhibits the reaction [Thapsigargin results in increased expression of PMAIP1 mRNA] decreases reaction
/ increases expression
mRNA 20022965
D019284 5366 PMAIP1
APR
NOXA
phorbol-12-myristate-13-acetate-induced protein 1 ATF4 mutant form inhibits the reaction [Thapsigargin results in increased expression of PMAIP1 protein] decreases reaction
/ increases expression
protein 20022965
D019284 5366 PMAIP1
APR
NOXA
phorbol-12-myristate-13-acetate-induced protein 1 Cycloheximide inhibits the reaction [Thapsigargin results in increased expression of PMAIP1 protein] decreases reaction
/ increases expression
protein 17216584
D019284 5366 PMAIP1
APR
NOXA
phorbol-12-myristate-13-acetate-induced protein 1 Thapsigargin promotes the reaction [ATF4 protein binds to PMAIP1 promoter] affects binding
/ increases reaction
promoter 20022965
D019284 5366 PMAIP1
APR
NOXA
phorbol-12-myristate-13-acetate-induced protein 1 Thapsigargin results in increased expression of PMAIP1 mRNA increases expression
mRNA 17216584
20022965
D019284 5366 PMAIP1
APR
NOXA
phorbol-12-myristate-13-acetate-induced protein 1 Thapsigargin results in increased expression of PMAIP1 protein increases expression
protein 17216584
20022965
D019284 23645 PPP1R15A
GADD34
protein phosphatase 1, regulatory subunit 15A [4-methylene-2-octyl-5-oxofuran-3-carboxylic acid co-treated with Thapsigargin] results in increased expression of PPP1R15A mRNA affects cotreatment
/ increases expression
mRNA 17283163
D019284 23645 PPP1R15A
GADD34
protein phosphatase 1, regulatory subunit 15A Thapsigargin results in increased expression of PPP1R15A mRNA increases expression
mRNA 19135031
20022965
21694771
D019284 5530 PPP3CA
CALN
CALNA
CALNA1
CCN1
CNA1
PPP2B
protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) [cypermethrin results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargin decreases activity
/ decreases response to substance
protein 10898953
D019284 5530 PPP3CA
CALN
CALNA
CALNA1
CCN1
CNA1
PPP2B
protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) [Tacrolimus results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargin decreases activity
/ decreases response to substance
protein 10898953
D019284 5530 PPP3CA
CALN
CALNA
CALNA1
CCN1
CNA1
PPP2B
protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) Thapsigargin promotes the reaction [PPP3CA protein results in decreased phosphorylation of NFATC1 protein] decreases phosphorylation
/ increases reaction
protein 10898953
D019284 5530 PPP3CA
CALN
CALNA
CALNA1
CCN1
CNA1
PPP2B
protein phosphatase 3, catalytic subunit, alpha isozyme (EC:3.1.3.16) Thapsigargin results in increased cleavage of PPP3CA protein increases cleavage
protein 10898953
D019284 25824 PRDX5
ACR1
AOEB166
B166
PLP
PMP20
PRDX6
PRXV
prx-V
peroxiredoxin 5 (EC:1.11.1.15) 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of PRDX5 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 25824 PRDX5
ACR1
AOEB166
B166
PLP
PMP20
PRDX6
PRXV
prx-V
peroxiredoxin 5 (EC:1.11.1.15) caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PRDX5 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 25824 PRDX5
ACR1
AOEB166
B166
PLP
PMP20
PRDX6
PRXV
prx-V
peroxiredoxin 5 (EC:1.11.1.15) Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of PRDX5 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 25824 PRDX5
ACR1
AOEB166
B166
PLP
PMP20
PRDX6
PRXV
prx-V
peroxiredoxin 5 (EC:1.11.1.15) Thapsigargin results in decreased expression of PRDX5 mRNA decreases expression
mRNA 19442820
D019284 5579 PRKCB
PKC-beta
PKCB
PRKCB1
PRKCB2
protein kinase C, beta (EC:2.7.11.13) Thapsigargin inhibits the reaction [EGF protein affects the localization of PRKCB protein] affects localization
/ decreases reaction
protein 17991733
D019284 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of PTGS2 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTGS2 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of PTGS2 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Thapsigargin results in increased expression of PTGS2 mRNA increases expression
mRNA 21694771
D019284 5806 PTX3
TNFAIP5
TSG-14
pentraxin 3, long 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of PTX3 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 5806 PTX3
TNFAIP5
TSG-14
pentraxin 3, long caffeic acid promotes the reaction [Thapsigargin results in decreased expression of PTX3 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 5806 PTX3
TNFAIP5
TSG-14
pentraxin 3, long Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of PTX3 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 5955 RCN2
E6BP
ERC-55
ERC55
TCBP49
reticulocalbin 2, EF-hand calcium binding domain Thapsigargin results in decreased expression of RCN2 mRNA decreases expression
mRNA 21692457
D019284 5955 RCN2
E6BP
ERC-55
ERC55
TCBP49
reticulocalbin 2, EF-hand calcium binding domain Thapsigargin results in decreased expression of RCN2 protein decreases expression
protein 21692457
D019284 6284 S100A13
S100 calcium binding protein A13 Thapsigargin results in increased expression of S100A13 mRNA increases expression
mRNA 19442820
D019284 51435 SCARA3
APC7
CSR
CSR1
MSLR1
MSRL1
scavenger receptor class A, member 3 Thapsigargin results in increased expression of SCARA3 mRNA increases expression
mRNA 19442820
D019284 23256 SCFD1
C14orf163
RA410
SLY1
SLY1P
STXBP1L2
sec1 family domain containing 1 Thapsigargin results in decreased expression of SCFD1 protein decreases expression
protein 21692457
D019284 6326 SCN2A
BFIC3
BFIS3
BFNIS
EIEE11
HBA
HBSCI
HBSCII
NAC2
Na(v)1.2
Nav1.2
SCN2A1
SCN2A2
sodium channel, voltage-gated, type II, alpha subunit 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in increased expression of SCN2A mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 6326 SCN2A
BFIC3
BFIS3
BFNIS
EIEE11
HBA
HBSCI
HBSCII
NAC2
Na(v)1.2
Nav1.2
SCN2A1
SCN2A2
sodium channel, voltage-gated, type II, alpha subunit Thapsigargin results in increased expression of SCN2A mRNA increases expression
mRNA 19442820
D019284 5265 SERPINA1
A1A
A1AT
AAT
PI
PI1
PRO2275
alpha1AT
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 Thapsigargin results in increased expression of SERPINA1 protein increases expression
protein 21692457
D019284 5055 SERPINB2
HsT1201
PAI
PAI-2
PAI2
PLANH2
serpin peptidase inhibitor, clade B (ovalbumin), member 2 Thapsigargin results in increased expression of SERPINB2 mRNA increases expression
mRNA 19442820
D019284 6418 SET
2PP2A
I2PP2A
IGAAD
IPP2A2
PHAPII
TAF-I
TAF-IBETA
SET nuclear oncogene Thapsigargin results in decreased expression of SET mRNA decreases expression
mRNA 21692457
D019284 6418 SET
2PP2A
I2PP2A
IGAAD
IPP2A2
PHAPII
TAF-I
TAF-IBETA
SET nuclear oncogene Thapsigargin results in decreased expression of SET protein decreases expression
protein 21692457
D019284 119559 SFXN4
BCRM1
sideroflexin 4 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of SFXN4 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 119559 SFXN4
BCRM1
sideroflexin 4 caffeic acid promotes the reaction [Thapsigargin results in decreased expression of SFXN4 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 119559 SFXN4
BCRM1
sideroflexin 4 Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of SFXN4 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 119559 SFXN4
BCRM1
sideroflexin 4 Thapsigargin results in decreased expression of SFXN4 mRNA decreases expression
mRNA 19442820
D019284 6786 STIM1
D11S4896E
GOK
IMD10
TAM
stromal interaction molecule 1 [Thapsigargin co-treated with Ionomycin] promotes the reaction [STIM1 protein binds to ATP2A3 protein] affects binding
/ affects cotreatment
/ increases reaction
protein 18439569
D019284 202374 STK32A
YANK1
serine/threonine kinase 32A (EC:2.7.11.1) [Thapsigargin co-treated with caffeic acid] results in decreased expression of STK32A mRNA affects cotreatment
/ decreases expression
mRNA 19442820
D019284 202374 STK32A
YANK1
serine/threonine kinase 32A (EC:2.7.11.1) Thapsigargin results in decreased expression of STK32A mRNA decreases expression
mRNA 19442820
D019284 10492 SYNCRIP
GRY-RBP
GRYRBP
HNRNPQ
HNRPQ1
NSAP1
PP68
hnRNP-Q
synaptotagmin binding, cytoplasmic RNA interacting protein Thapsigargin affects the localization of SYNCRIP protein affects localization
protein 19331829
D019284 7052 TGM2
G-ALPHA-h
GNAH
TG2
TGC
transglutaminase 2 (EC:2.3.2.13) Thapsigargin results in increased expression of and results in increased activity of TGM2 protein increases activity
/ increases expression
protein 16382148
D019284 10469 TIMM44
TIM44
translocase of inner mitochondrial membrane 44 homolog (yeast) Thapsigargin results in decreased expression of TIMM44 mRNA decreases expression
mRNA 19442820
D019284 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Thapsigargin results in increased expression of TNF mRNA increases expression
mRNA 18951912
21694771
D019284 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 caffeic acid promotes the reaction [Thapsigargin results in decreased expression of TP53 mRNA] decreases expression
/ increases reaction
mRNA 19442820
D019284 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Thapsigargin results in decreased expression of TP53 mRNA decreases expression
mRNA 19442820
D019284 7222 TRPC3
TRP3
transient receptor potential cation channel, subfamily C, member 3 Thapsigargin promotes the reaction [TRPC3 protein results in increased transport of Calcium] increases reaction
/ increases transport
protein 12700192
D019284 7272 TTK
CT96
ESK
MPH1
MPS1
MPS1L1
PYT
TTK protein kinase (EC:2.7.12.1) Thapsigargin results in increased expression of TTK mRNA increases expression
mRNA 19442820
D019284 203068 TUBB
M40
OK/SW-cl.56
TUBB1
TUBB5
tubulin, beta class I Thapsigargin results in decreased expression of TUBB protein decreases expression
protein 21692457
D019284 10190 TXNDC9
APACD
PHLP3
thioredoxin domain containing 9 Thapsigargin results in decreased expression of TXNDC9 protein decreases expression
protein 21692457
D019284 11065 UBE2C
UBCH10
dJ447F3.2
ubiquitin-conjugating enzyme E2C (EC:6.3.2.19) caffeic acid promotes the reaction [Thapsigargin results in increased expression of UBE2C mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 11065 UBE2C
UBCH10
dJ447F3.2
ubiquitin-conjugating enzyme E2C (EC:6.3.2.19) Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of UBE2C mRNA] increases expression
/ increases reaction
mRNA 19442820
D019284 11065 UBE2C
UBCH10
dJ447F3.2
ubiquitin-conjugating enzyme E2C (EC:6.3.2.19) Thapsigargin results in increased expression of UBE2C mRNA increases expression
mRNA 19442820
D019284 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A [Thapsigargin results in increased activity of CREB3L1 protein] which results in increased expression of VEGFA mRNA increases activity
/ increases expression
mRNA 23383089
D019284 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Thapsigargin results in increased expression of VEGFA mRNA increases expression
mRNA 12147617
23383089
D019284 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Thapsigargin results in increased secretion of VEGFA protein increases secretion
protein 12147617
D019284 7494 XBP1
TREB5
XBP-1
XBP2
X-box binding protein 1 Thapsigargin results in increased activity of XBP1 protein increases activity
protein 20816668
23383089
D019284 7494 XBP1
TREB5
XBP-1
XBP2
X-box binding protein 1 Thapsigargin results in increased expression of XBP1 mRNA alternative form increases expression
mRNA 18773883
D019284 7494 XBP1
TREB5
XBP-1
XBP2
X-box binding protein 1 Thapsigargin results in increased splicing of XBP1 mRNA increases splicing
mRNA 17353921
19428936
D019284 7494 XBP1
TREB5
XBP-1
XBP2
X-box binding protein 1 XBP1 protein results in decreased susceptibility to Thapsigargin decreases response to substance
protein 19135031
D019284 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of XIAP mRNA] decreases reaction
/ increases expression
mRNA 15339911
D019284 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of XIAP protein] decreases reaction
/ increases expression
protein 15339911
D019284 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis Thapsigargin results in decreased expression of XIAP protein decreases expression
protein 16382148
D019284 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis Thapsigargin results in increased expression of XIAP mRNA increases expression
mRNA 15339911
D019284 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis Thapsigargin results in increased expression of XIAP protein increases expression
protein 15339911
D019284 7531 YWHAE
14-3-3E
KCIP-1
MDCR
MDS
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide Thapsigargin results in decreased expression of YWHAE protein decreases expression
protein 21692457

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (52)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#210900 Bloom syndrome; blm P54132
#601003 Brody myopathy O14983
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#257220 Niemann-pick disease, type c1; npc1 O15118
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#609620 Short qt syndrome 1; sqt1 Q12809
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (75)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01129 Brody myopathy O14983 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00125 Fabry disease P06280 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)