PCIDB

KNApSAcK Metabolite C00033777

Metabolite

KNApSAcK Entry

id C00033777
Name Dimethylarsinic acid
CAS RN 75-60-5
Standard InChI InChI=1S/C2H7AsO2/c1-3(2,4)5/h1-2H3,(H,4,5)
Standard InChI (Main Layer) InChI=1S/C2H7AsO2/c1-3(2,4)5/h1-2H3,(H,4,5)

Cluster

Phytochemical cluster
KCF-S cluster No. 8902

Link

ChEMBL

By standard InChI CHEMBL1231644
By standard InChI Main Layer CHEMBL1231644

KEGG

By LinkDB C07308

CTD

By CAS RN D002101

Human Protein / Gene in interaction

4 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q16637 Survival motor neuron protein Unclassified protein CHEMBL1231644 CHEMBL1613842 (1)
4 / 2
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL1231644 CHEMBL1738606 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL1231644 CHEMBL2114780 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL1231644 CHEMBL1794536 (1)
0 / 0

CTD interaction (35)

compound gene gene name gene description interaction interaction type form reference
pmid
D002101 351 APP
AAA
ABETA
ABPP
AD1
APPI
CTFgamma
CVAP
PN-II
PN2
amyloid beta (A4) precursor protein Cacodylic Acid results in increased cleavage of and affects the secretion of APP protein mutant form affects secretion
/ increases cleavage
protein 21440049
D002101 351 APP
AAA
ABETA
ABPP
AD1
APPI
CTFgamma
CVAP
PN-II
PN2
amyloid beta (A4) precursor protein Cacodylic Acid results in increased expression of and affects the localization of APP protein mutant form affects localization
/ increases expression
protein 21440049
D002101 57584 ARHGAP21
ARHGAP10
Rho GTPase activating protein 21 Cacodylic Acid results in increased expression of ARHGAP21 mRNA increases expression
mRNA 17720352
D002101 57412 AS3MT
CYT19
arsenic (+3 oxidation state) methyltransferase (EC:2.1.1.137) [AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of Cacodylic Acid increases chemical synthesis
/ increases metabolic processing
protein 22868225
D002101 57412 AS3MT
CYT19
arsenic (+3 oxidation state) methyltransferase (EC:2.1.1.137) [AS3MT protein polymorphism results in increased metabolism of monomethylarsonic acid] which results in increased chemical synthesis of Cacodylic Acid increases chemical synthesis
/ increases metabolic processing
protein 22868225
D002101 57412 AS3MT
CYT19
arsenic (+3 oxidation state) methyltransferase (EC:2.1.1.137) [AS3MT protein results in increased metabolism of arsenite] which results in increased chemical synthesis of Cacodylic Acid increases chemical synthesis
/ increases metabolic processing
protein 22868225
D002101 57412 AS3MT
CYT19
arsenic (+3 oxidation state) methyltransferase (EC:2.1.1.137) [AS3MT protein results in increased metabolism of monomethylarsonic acid] which results in increased chemical synthesis of Cacodylic Acid increases chemical synthesis
/ increases metabolic processing
protein 22868225
D002101 468 ATF4
CREB-2
CREB2
TAXREB67
TXREB
activating transcription factor 4 Cacodylic Acid results in increased expression of ATF4 mRNA increases expression
mRNA 23221991
D002101 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 Cacodylic Acid results in increased expression of BCL2L1 mRNA increases expression
mRNA 17720352
D002101 649 BMP1
OI13
PCOLC
PCP
PCP2
TLD
bone morphogenetic protein 1 (EC:3.4.24.19) Cacodylic Acid results in decreased expression of BMP1 mRNA decreases expression
mRNA 17720352
D002101 771 CA12
CAXII
HsT18816
carbonic anhydrase XII (EC:4.2.1.1) Cacodylic Acid results in increased expression of CA12 mRNA increases expression
mRNA 17720352
D002101 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Cacodylic Acid results in increased activity of CASP3 protein increases activity
protein 19465042
D002101 858 CAV2
CAV
caveolin 2 Cacodylic Acid results in decreased expression of CAV2 mRNA decreases expression
mRNA 17720352
D002101 948 CD36
BDPLT10
CHDS7
FAT
GP3B
GP4
GPIV
PASIV
SCARB3
CD36 molecule (thrombospondin receptor) Cacodylic Acid results in decreased expression of CD36 mRNA decreases expression
mRNA 23221991
D002101 968 CD68
GP110
LAMP4
SCARD1
CD68 molecule Cacodylic Acid results in increased expression of CD68 mRNA increases expression
mRNA 17720352
D002101 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 Cacodylic Acid results in increased expression of DDIT3 mRNA increases expression
mRNA 23221991
D002101 27165 GLS2
GA
GLS
LGA
hLGA
glutaminase 2 (liver, mitochondrial) (EC:3.5.1.2) Cacodylic Acid results in increased expression of GLS2 mRNA increases expression
mRNA 17720352
D002101 2941 GSTA4
GSTA4-4
GTA4
glutathione S-transferase alpha 4 (EC:2.5.1.18) Cacodylic Acid results in increased expression of GSTA4 mRNA increases expression
mRNA 17720352
D002101 2952 GSTT1
glutathione S-transferase theta 1 (EC:2.5.1.18) GSTT1 gene affects the susceptibility to Cacodylic Acid affects response to substance
gene 17431481
D002101 2952 GSTT1
glutathione S-transferase theta 1 (EC:2.5.1.18) GSTT1 protein affects the metabolism of Cacodylic Acid affects metabolic processing
protein 17431481
D002101 11009 IL24
C49A
FISP
IL10B
MDA7
MOB5
ST16
interleukin 24 Cacodylic Acid results in increased expression of IL24 mRNA increases expression
mRNA 17720352
D002101 3663 IRF5
SLEB10
interferon regulatory factor 5 Cacodylic Acid results in decreased expression of IRF5 mRNA decreases expression
mRNA 17720352
D002101 4023 LPL
HDLCQ11
LIPD
lipoprotein lipase (EC:3.1.1.34) Cacodylic Acid results in decreased expression of LPL mRNA decreases expression
mRNA 23221991
D002101 11184 MAP4K1
HPK1
mitogen-activated protein kinase kinase kinase kinase 1 (EC:2.7.11.1) Cacodylic Acid results in decreased expression of MAP4K1 mRNA decreases expression
mRNA 17720352
D002101 3084 NRG1
ARIA
GGF
GGF2
HGL
HRG
HRG1
HRGA
MST131
NDF
SMDF
neuregulin 1 Cacodylic Acid results in increased expression of NRG1 mRNA increases expression
mRNA 17720352
D002101 5097 PCDH1
PC42
PCDH42
protocadherin 1 Cacodylic Acid results in decreased expression of PCDH1 mRNA decreases expression
mRNA 17720352
D002101 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma Cacodylic Acid results in decreased expression of PPARG mRNA decreases expression
mRNA 23221991
D002101 19349 Cacodylic Acid results in decreased expression of RAB7 mRNA decreases expression
mRNA 17720352
D002101 121260 SLC15A4
PHT1
PTR4
solute carrier family 15 (oligopeptide transporter), member 4 Cacodylic Acid results in decreased expression of SLC15A4 mRNA decreases expression
mRNA 17720352
D002101 23169 SLC35D1
UGTREL7
solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 Cacodylic Acid results in increased expression of SLC35D1 mRNA increases expression
mRNA 17720352
D002101 7039 TGFA
TFGA
transforming growth factor, alpha Cacodylic Acid results in increased expression of TGFA mRNA increases expression
mRNA 17720352
D002101 9098 USP6
HRP1
TRE17
TRE2
Tre-2
USP6-short
ubiquitin specific peptidase 6 (Tre-2 oncogene) (EC:3.4.19.12) Cacodylic Acid results in increased expression of USP6 mRNA increases expression
mRNA 17720352
D002101 7874 USP7
HAUSP
TEF1
ubiquitin specific peptidase 7 (herpes virus-associated) (EC:3.4.19.12) Cacodylic Acid results in increased expression of USP7 mRNA increases expression
mRNA 17720352
D002101 7494 XBP1
TREB5
XBP-1
XBP2
X-box binding protein 1 Cacodylic Acid results in increased expression of XBP1 mRNA increases expression
mRNA 23221991
D002101 7494 XBP1
TREB5
XBP-1
XBP2
X-box binding protein 1 Cacodylic Acid results in increased expression of XBP1 mRNA alternative form increases expression
mRNA 23221991

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (4)

OMIM preferred title UniProt
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637

KEGG DISEASE (1)

KEGG disease name UniProt
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)

Diseases related to CTD interactions

14 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000236 D002101 Adenoma marker/mechanism
16039397
D001943 D002101 Breast Neoplasms marker/mechanism
17474063
D002295 D002101 Carcinoma, Transitional Cell marker/mechanism
12151359
D002471 D002101 Cell Transformation, Neoplastic marker/mechanism
12115560
D002869 D002101 Chromosome Aberrations marker/mechanism
14563531
D006965 D002101 Hyperplasia marker/mechanism
12151359
D008114 D002101 Liver Neoplasms, Experimental marker/mechanism
12115560
D008175 D002101 Lung Neoplasms marker/mechanism
16039397
17441966
19239017
D008223 D002101 Lymphoma marker/mechanism
17441966
D009336 D002101 Necrosis marker/mechanism
9548797
D010212 D002101 Papilloma marker/mechanism
12151359
D011230 D002101 Precancerous Conditions marker/mechanism
12151359
D012878 D002101 Skin Neoplasms marker/mechanism
16039397
D001749 D002101 Urinary Bladder Neoplasms marker/mechanism
12151359
15537745
15950995