KNApSAcK Metabolite C00003394
Metabolite
KNApSAcK Entry
| id | C00003394 |
|---|---|
| Name | Xanthatin |
| CAS RN | 26791-73-1 |
| Standard InChI | InChI=1S/C15H18O3/c1-9-8-14-13(11(3)15(17)18-14)7-6-12(9)5-4-10(2)16/h4-6,9,13-14H,3,7-8H2,1-2H3/b5-4+/t9-,13+,14-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C15H18O3/c1-9-8-14-13(11(3)15(17)18-14)7-6-12(9)5-4-10(2)16/h4-6,9,13-14H,3,7-8H2,1-2H3 |
Cluster
| Phytochemical cluster | No. 38 |
|---|---|
| KCF-S cluster | No. 857 |
Link
ChEMBL
| By standard InChI | CHEMBL404466 |
|---|---|
| By standard InChI Main Layer | CHEMBL404466 CHEMBL1983676 |
KEGG
| By LinkDB | C09601 |
|---|
CTD
| By CAS RN | C022186 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| asterids | 3 |
Family
| family name | count |
|---|---|
| Asteraceae | 3 |
List (3)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Xanthium pensylvanicum | 36590 | Asteraceae | asterids | Viridiplantae |
| Xanthium riparium | 36590 | Asteraceae | asterids | Viridiplantae |
| Xanthium sibiricum | 576365 | Asteraceae | asterids | Viridiplantae |
Human Protein / Gene in interaction
CTD interaction (11)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C022186 | 891 |
CCNB1
CCNB |
cyclin B1 | xanthatin results in decreased expression of CCNB1 mRNA |
decreases expression
|
mRNA |
21568272
|
| C022186 | 983 |
CDK1
CDC2 CDC28A P34CDC2 |
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) | xanthatin results in decreased expression of CDK1 mRNA |
decreases expression
|
mRNA |
21568272
|
| C022186 | 10912 |
GADD45G
CR6 DDIT2 GADD45gamma GRP17 |
growth arrest and DNA-damage-inducible, gamma | Acetylcysteine inhibits the reaction [xanthatin results in increased expression of GADD45G mRNA] |
decreases reaction
/ increases expression |
mRNA |
23313378
|
| C022186 | 10912 |
GADD45G
CR6 DDIT2 GADD45gamma GRP17 |
growth arrest and DNA-damage-inducible, gamma | Acetylcysteine inhibits the reaction [[xanthatin results in increased expression of GADD45G mRNA] which results in increased abundance of Reactive Oxygen Species] |
decreases reaction
/ increases abundance / increases expression |
mRNA |
23313378
|
| C022186 | 10912 |
GADD45G
CR6 DDIT2 GADD45gamma GRP17 |
growth arrest and DNA-damage-inducible, gamma | Acetylcysteine inhibits the reaction [xanthatin results in increased expression of GADD45G protein] |
decreases reaction
/ increases expression |
protein |
23313378
|
| C022186 | 10912 |
GADD45G
CR6 DDIT2 GADD45gamma GRP17 |
growth arrest and DNA-damage-inducible, gamma | xanthatin results in increased expression of GADD45G mRNA |
increases expression
|
mRNA |
21568272
23313378 |
| C022186 | 10912 |
GADD45G
CR6 DDIT2 GADD45gamma GRP17 |
growth arrest and DNA-damage-inducible, gamma | [xanthatin results in increased expression of GADD45G mRNA] which results in increased abundance of Reactive Oxygen Species |
increases abundance
/ increases expression |
mRNA |
23313378
|
| C022186 | 10912 |
GADD45G
CR6 DDIT2 GADD45gamma GRP17 |
growth arrest and DNA-damage-inducible, gamma | xanthatin results in increased expression of GADD45G protein |
increases expression
|
protein |
23313378
|
| C022186 | 3162 |
HMOX1
HMOX1D HO-1 HSP32 bK286B10 |
heme oxygenase (decycling) 1 (EC:1.14.99.3) | xanthatin results in increased expression of HMOX1 mRNA |
increases expression
|
mRNA |
21568272
|
| C022186 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | xanthatin results in increased expression of IL1B mRNA |
increases expression
|
mRNA |
21568272
|
| C022186 | 7153 |
TOP2A
TOP2 TP2A |
topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) | xanthatin results in decreased activity of TOP2A protein |
decreases activity
|
protein |
23313378
|