PCIDB

KNApSAcK Metabolite C00034542

Metabolite

KNApSAcK Entry

id C00034542
Name Hyperforin
CAS RN 11079-53-1
Standard InChI InChI=1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3/t27-,33+,34+,35-/m0/s1
Standard InChI (Main Layer) InChI=1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3

Cluster

Phytochemical cluster
KCF-S cluster No. 1992

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL1571879

KEGG

By LinkDB C07608

CTD

By CAS RN C001654

Human Protein / Gene in interaction

6 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q16637 Survival motor neuron protein Unclassified protein CHEMBL1571879 CHEMBL1613842 (1)
4 / 2
P11473 Vitamin D3 receptor NR1I1 CHEMBL1571879 CHEMBL1794311 (1)
2 / 3
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL1571879 CHEMBL1738606 (1)
0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL1571879 CHEMBL1963893 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1571879 CHEMBL1614421 (1) CHEMBL1614502 (1)
4 / 3
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1571879 CHEMBL1738442 (1)
0 / 0

CTD interaction (29)

compound gene gene name gene description interaction interaction type form reference
pmid
C001654 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) hyperforin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] decreases reaction
/ increases secretion
protein 15266218
C001654 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) hyperforin results in increased expression of ABCB1 increases expression
16005588
C001654 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) hyperforin inhibits the reaction [CYP1A1 protein affects the metabolism of benzo(a)pyrene 7,8-dihydrodiol] affects metabolic processing
/ decreases reaction
protein 14633740
C001654 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) hyperforin results in decreased activity of CYP1A1 protein decreases activity
protein 14633740
C001654 1591 CYP24A1
CP24
CYP24
HCAI
P450-CC24
cytochrome P450, family 24, subfamily A, polypeptide 1 (EC:1.14.13.126) hyperforin results in increased expression of CYP24A1 mRNA increases expression
mRNA 15630458
C001654 1559 CYP2C9
CPC9
CYP2C
CYP2C10
CYPIIC9
P450IIC9
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) hyperforin results in increased expression of and results in increased activity of CYP2C9 protein increases activity
/ increases expression
protein 15100173
C001654 1559 CYP2C9
CPC9
CYP2C
CYP2C10
CYPIIC9
P450IIC9
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) hyperforin results in increased expression of CYP2C9 mRNA increases expression
mRNA 14600250
15100173
C001654 1559 CYP2C9
CPC9
CYP2C
CYP2C10
CYPIIC9
P450IIC9
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) NR1I2 protein affects the reaction [hyperforin results in increased expression of CYP2C9 mRNA] affects reaction
/ increases expression
mRNA 14600250
C001654 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) hyperforin results in decreased activity of CYP3A4 protein decreases activity
protein 15100173
C001654 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) hyperforin results in increased expression of and results in increased activity of CYP3A4 protein increases activity
/ increases expression
protein 15100173
C001654 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) hyperforin results in increased expression of CYP3A4 increases expression
16005588
C001654 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) hyperforin results in increased expression of CYP3A4 mRNA increases expression
mRNA 15100173
15266218
16442130
17954527
C001654 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 hyperforin results in increased expression of ICAM1 mRNA increases expression
mRNA 15622447
C001654 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [hyperforin results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 15622447
C001654 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [hyperforin results in increased secretion of IL8 protein] decreases reaction
/ increases secretion
protein 15622447
C001654 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 hyperforin promotes the reaction [JUN protein binds to IL8 promoter] affects binding
/ increases reaction
promoter 15622447
C001654 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 hyperforin results in increased expression of IL8 mRNA increases expression
mRNA 15622447
C001654 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 hyperforin results in increased secretion of IL8 protein increases secretion
protein 15622447
C001654 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 SB 203580 inhibits the reaction [hyperforin results in increased secretion of IL8 protein] decreases reaction
/ increases secretion
protein 15622447
C001654 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 U 0126 inhibits the reaction [hyperforin results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 15622447
C001654 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 U 0126 inhibits the reaction [hyperforin results in increased secretion of IL8 protein] decreases reaction
/ increases secretion
protein 15622447
C001654 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene hyperforin promotes the reaction [JUN protein binds to IL8 promoter] affects binding
/ increases reaction
protein 15622447
C001654 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) hyperforin results in increased phosphorylation of MAPK1 protein increases phosphorylation
protein 15622447
C001654 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) hyperforin results in increased phosphorylation of MAPK3 protein increases phosphorylation
protein 15622447
C001654 110357 hyperforin results in increased expression of MOD2 mRNA increases expression
mRNA 16442130
C001654 8856 NR1I2
BXR
ONR1
PAR
PAR1
PAR2
PARq
PRR
PXR
SAR
SXR
nuclear receptor subfamily 1, group I, member 2 hyperforin binds to and results in increased activity of NR1I2 protein affects binding
/ increases activity
protein 15630458
C001654 8856 NR1I2
BXR
ONR1
PAR
PAR1
PAR2
PARq
PRR
PXR
SAR
SXR
nuclear receptor subfamily 1, group I, member 2 hyperforin results in increased activity of NR1I2 protein increases activity
protein 15856409
C001654 8856 NR1I2
BXR
ONR1
PAR
PAR1
PAR2
PARq
PRR
PXR
SAR
SXR
nuclear receptor subfamily 1, group I, member 2 NR1I2 protein affects the reaction [hyperforin results in increased expression of CYP2C9 mRNA] affects reaction
/ increases expression
protein 14600250
C001654 8856 NR1I2
BXR
ONR1
PAR
PAR1
PAR2
PARq
PRR
PXR
SAR
SXR
nuclear receptor subfamily 1, group I, member 2 NR1I2 protein promotes the reaction [hyperforin results in increased abundance of Lipids] increases abundance
/ increases reaction
protein 20079722

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#600274 Frontotemporal dementia; ftd P10636
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (7)

KEGG disease name UniProt
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)

Diseases related to CTD interactions

2 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D008569 C001654 Memory Disorders therapeutic
18599028
D010146 C001654 Pain therapeutic
19945352