KNApSAcK Metabolite C00036010
Metabolite
KNApSAcK Entry
| id | C00036010 |
|---|---|
| Name | 4,4'-Dihydroxystilbene |
| CAS RN | 659-22-3 |
| Standard InChI | InChI=1S/C14H12O2/c15-13-7-3-11(4-8-13)1-2-12-5-9-14(16)10-6-12/h1-10,15-16H/b2-1+ |
| Standard InChI (Main Layer) | InChI=1S/C14H12O2/c15-13-7-3-11(4-8-13)1-2-12-5-9-14(16)10-6-12/h1-10,15-16H |
Cluster
| Phytochemical cluster | No. 13 |
|---|---|
| KCF-S cluster | No. 295 |
Link
ChEMBL
| By standard InChI | CHEMBL196731 |
|---|---|
| By standard InChI Main Layer | CHEMBL196731 |
KEGG
| By LinkDB | C14233 |
|---|
CTD
| By CAS RN | C010118 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| Liliopsida | 1 |
Family
| family name | count |
|---|---|
| Asparagaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Yucca periculosa F.Baker | 39550 | Asparagaceae | Liliopsida | Viridiplantae |
Human Protein / Gene in interaction
2 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q92731 | Estrogen receptor beta | NR3A2 | CHEMBL196731 |
CHEMBL1043956
(1)
CHEMBL1043959
(1)
CHEMBL1044866 (1) |
0 / 1 |
| P03372 | Estrogen receptor | NR3A1 | CHEMBL196731 |
CHEMBL1043955
(1)
CHEMBL1043958
(1)
CHEMBL1043961 (1) |
1 / 1 |
CTD interaction (11)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C010118 | 890 |
CCNA2
CCN1 CCNA |
cyclin A2 | 4,4'-dihydroxystilbene results in increased expression of CCNA2 mRNA |
increases expression
|
mRNA |
19496085
|
| C010118 | 1509 |
CTSD
CLN10 CPSD |
cathepsin D (EC:3.4.23.5) | 4,4'-dihydroxystilbene results in increased expression of CTSD mRNA |
increases expression
|
mRNA |
19496085
|
| C010118 | 1889 |
ECE1
ECE |
endothelin converting enzyme 1 (EC:3.4.24.71) | 4,4'-dihydroxystilbene results in decreased activity of ECE1 protein |
decreases activity
|
protein |
21554123
|
| C010118 | 1889 |
ECE1
ECE |
endothelin converting enzyme 1 (EC:3.4.24.71) | 4,4'-dihydroxystilbene results in decreased expression of ECE1 mRNA |
decreases expression
|
mRNA |
21554123
|
| C010118 | 1906 |
EDN1
ET1 HDLCQ7 PPET1 |
endothelin 1 | 4,4'-dihydroxystilbene results in decreased expression of EDN1 mRNA |
decreases expression
|
mRNA |
21554123
|
| C010118 | 1906 |
EDN1
ET1 HDLCQ7 PPET1 |
endothelin 1 | 4,4'-dihydroxystilbene results in decreased secretion of EDN1 protein |
decreases secretion
|
protein |
21554123
|
| C010118 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | 4,4'-dihydroxystilbene analog binds to and results in increased activity of ESR1 protein |
affects binding
/ increases activity |
protein |
19496085
|
| C010118 | 2099 |
ESR1
ER ESR ESRA ESTRR Era NR3A1 |
estrogen receptor 1 | fulvestrant inhibits the reaction [4,4'-dihydroxystilbene analog binds to and results in increased activity of ESR1 protein] |
affects binding
/ decreases reaction / increases activity |
protein |
19496085
|
| C010118 | 2353 |
FOS
AP-1 C-FOS p55 |
FBJ murine osteosarcoma viral oncogene homolog | 4,4'-dihydroxystilbene results in increased expression of FOS mRNA |
increases expression
|
mRNA |
19496085
|
| C010118 | 5241 |
PGR
NR3C3 PR |
progesterone receptor | 4,4'-dihydroxystilbene results in increased expression of PGR mRNA |
increases expression
|
mRNA |
19496085
|
| C010118 | 7031 |
TFF1
BCEI D21S21 HP1.A HPS2 pNR-2 pS2 |
trefoil factor 1 | 4,4'-dihydroxystilbene results in increased expression of TFF1 mRNA |
increases expression
|
mRNA |
19496085
|