PCIDB

KNApSAcK Metabolite C00037040

Metabolite

KNApSAcK Entry

id C00037040
Name Destruxin B
CAS RN 2503-26-6
Standard InChI InChI=1S/C30H49N5O7/c1-9-13-22-28(39)35-17-12-14-21(35)27(38)32-24(18(4)10-2)29(40)34(8)25(19(5)11-3)30(41)33(7)20(6)26(37)31-16-15-23(36)42-22/h9,18-22,24-25H,1,10-17H2,2-8H3,(H,31,37)(H,32,38)
Standard InChI (Main Layer) InChI=1S/C30H49N5O7/c1-9-13-22-28(39)35-17-12-14-21(35)27(38)32-24(18(4)10-2)29(40)34(8)25(19(5)11-3)30(41)33(7)20(6)26(37)31-16-15-23(36)42-22/h9,18-22,24-25H,1,10-17H2,2-8H3,(H,31,37)(H,32,38)

Cluster

Phytochemical cluster
KCF-S cluster No. 892

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL444243

KEGG

By LinkDB

CTD

By CAS RN C040424

Species

Summary

Plant class

class name count

Family

family name count
Pleosporaceae 1

List (3)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Alternaria brassicae 29911 Pleosporaceae Fungi
Metarrhizium anisopliae (Metchnikoff)
Trichothecium roseum TT103 4751 Fungi

Human Protein / Gene in interaction

CTD interaction (24)

compound gene gene name gene description interaction interaction type form reference
pmid
C040424 308 ANXA5
ANX5
ENX2
PP4
RPRGL3
annexin A5 destruxin B results in increased expression of ANXA5 protein increases expression
protein 22465936
C040424 581 BAX
BCL2L4
BCL2-associated X protein destruxin B results in increased expression of BAX protein increases expression
protein 22465936
C040424 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 destruxin B results in decreased expression of BCL2 protein decreases expression
protein 22465936
C040424 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 destruxin B results in decreased expression of BCL2L1 protein decreases expression
protein 22465936
C040424 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 destruxin B results in decreased expression of BIRC5 protein decreases expression
protein 22465936
C040424 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) destruxin B results in increased cleavage of and results in increased activity of CASP3 protein increases activity
/ increases cleavage
protein 22465936
C040424 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) destruxin B results in increased expression of CASP3 protein increases expression
protein 22465936
C040424 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 destruxin B results in decreased expression of CCND1 protein decreases expression
protein 22465936
C040424 1147 CHUK
IKBKA
IKK-alpha
IKK1
IKKA
NFKBIKA
TCF16
conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) destruxin B results in decreased expression of CHUK protein decreases expression
protein 22465936
C040424 1499 CTNNB1
CTNNB
MRD19
armadillo
catenin (cadherin-associated protein), beta 1, 88kDa destruxin B affects the localization of CTNNB1 protein affects localization
protein 22465936
C040424 1499 CTNNB1
CTNNB
MRD19
armadillo
catenin (cadherin-associated protein), beta 1, 88kDa destruxin B results in decreased activity of [TCF4 protein co-treated with CTNNB1 protein] affects cotreatment
/ decreases activity
protein 22465936
C040424 1499 CTNNB1
CTNNB
MRD19
armadillo
catenin (cadherin-associated protein), beta 1, 88kDa destruxin B results in decreased expression of CTNNB1 protein decreases expression
protein 22465936
C040424 1499 CTNNB1
CTNNB
MRD19
armadillo
catenin (cadherin-associated protein), beta 1, 88kDa destruxin B results in decreased expression of CTNNB1 protein modified form decreases expression
protein 22465936
C040424 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog destruxin B results in decreased expression of FOS protein decreases expression
protein 22465936
C040424 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene destruxin B results in decreased expression of JUN protein decreases expression
protein 22465936
C040424 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) destruxin B results in decreased expression of MMP2 mRNA decreases expression
mRNA 22465936
C040424 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) destruxin B results in decreased expression of MMP9 mRNA decreases expression
mRNA 22465936
C040424 4609 MYC
MRTL
MYCC
bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog destruxin B results in decreased expression of MYC protein decreases expression
protein 22465936
C040424 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha destruxin B results in increased expression of NFKBIA protein increases expression
protein 22465936
C040424 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) destruxin B results in increased cleavage of PARP1 protein increases cleavage
protein 22465936
C040424 5175 PECAM1
CD31
CD31/EndoCAM
GPIIA'
PECA1
PECAM-1
endoCAM
platelet/endothelial cell adhesion molecule 1 destruxin B results in decreased expression of PECAM1 protein decreases expression
protein 22465936
C040424 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A destruxin B results in decreased expression of RELA protein decreases expression
protein 22465936
C040424 6925 TCF4
E2-2
ITF-2
ITF2
PTHS
SEF-2
SEF2
SEF2-1
SEF2-1A
SEF2-1B
TCF-4
bHLHb19
transcription factor 4 destruxin B affects the localization of and results in decreased expression of TCF4 protein affects localization
/ decreases expression
protein 22465936
C040424 6925 TCF4
E2-2
ITF-2
ITF2
PTHS
SEF-2
SEF2
SEF2-1
SEF2-1A
SEF2-1B
TCF-4
bHLHb19
transcription factor 4 destruxin B results in decreased activity of [TCF4 protein co-treated with CTNNB1 protein] affects cotreatment
/ decreases activity
protein 22465936

Related Disease

Diseases related to CTD interactions

3 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D015179 C040424 Colorectal Neoplasms therapeutic
22465936
D009336 C040424 Necrosis marker/mechanism
22465936
D009361 C040424 Neoplasm Invasiveness therapeutic
22465936