PCIDB

KNApSAcK Metabolite C00038341

Metabolite

KNApSAcK Entry

id C00038341
Name 9-Methoxyellipticine
CAS RN 10371-86-5
Standard InChI InChI=1S/C18H16N2O/c1-10-15-9-19-7-6-13(15)11(2)18-17(10)14-8-12(21-3)4-5-16(14)20-18/h4-9,20H,1-3H3
Standard InChI (Main Layer) InChI=1S/C18H16N2O/c1-10-15-9-19-7-6-13(15)11(2)18-17(10)14-8-12(21-3)4-5-16(14)20-18/h4-9,20H,1-3H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 1510

Link

ChEMBL

By standard InChI CHEMBL19954
By standard InChI Main Layer CHEMBL19954

KEGG

By LinkDB

CTD

By CAS RN C001729

Species

Summary

Plant class

class name count
asterids 2

Family

family name count
Apocynaceae 2

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Ochrosia acuminata 453904 Apocynaceae asterids Viridiplantae
Ochrosia moorei 141590 Apocynaceae asterids Viridiplantae

Human Protein / Gene in interaction

40 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein CHEMBL19954 CHEMBL1614529 (1)
0 / 0
P17861 X-box-binding protein 1 Unclassified protein CHEMBL19954 CHEMBL1738682 (1)
1 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL19954 CHEMBL1738312 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL19954 CHEMBL2114784 (1)
1 / 1
P14618 Pyruvate kinase PKM Enzyme CHEMBL19954 CHEMBL1613996 (1) CHEMBL1614428 (1)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL19954 CHEMBL1614079 (1)
0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL19954 CHEMBL1614166 (1)
1 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL19954 CHEMBL1794486 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL19954 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL19954 CHEMBL2114843 (1)
0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL19954 CHEMBL1613838 (1)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL19954 CHEMBL1963933 (1)
1 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL19954 CHEMBL2114788 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL19954 CHEMBL1794569 (1)
1 / 1
P11308 Transcriptional regulator ERG Unclassified protein CHEMBL19954 CHEMBL2114924 (1)
1 / 2
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL19954 CHEMBL1614319 (1) CHEMBL1614410 (1)
CHEMBL1613809 (1) CHEMBL1613988 (1)
1 / 3
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL19954 CHEMBL1963893 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL19954 CHEMBL963779 (1)
0 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL19954 CHEMBL1738588 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL19954 CHEMBL1794483 (1)
0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL19954 CHEMBL1614052 (1)
1 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL19954 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL19954 CHEMBL1614421 (1) CHEMBL1614502 (1)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL19954 CHEMBL1738184 (1)
0 / 0
P10721 Mast/stem cell growth factor receptor Kit Pdgfr CHEMBL19954 CHEMBL880421 (1) CHEMBL883229 (1)
CHEMBL883395 (1) CHEMBL873572 (1)
4 / 4
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL19954 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL19954 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL19954 CHEMBL1613829 (1) CHEMBL1794433 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL19954 CHEMBL1738442 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL19954 CHEMBL2354311 (1)
1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme CHEMBL19954 CHEMBL1963966 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL19954 CHEMBL1614319 (1) CHEMBL1613809 (1)
CHEMBL1613988 (1)
2 / 5
P35372 Mu-type opioid receptor Opioid receptor CHEMBL19954 CHEMBL1963970 (1)
0 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL19954 CHEMBL1963970 (1)
0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein CHEMBL19954 CHEMBL2114913 (1)
0 / 3
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein CHEMBL19954 CHEMBL2114881 (1)
0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme CHEMBL19954 CHEMBL2114796 (1)
2 / 1
P43351 DNA repair protein RAD52 homolog Unclassified protein CHEMBL19954 CHEMBL2354285 (1)
0 / 0
P51531 Probable global transcription activator SNF2L2 Unclassified protein CHEMBL19954 CHEMBL2354206 (1)
1 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL19954 CHEMBL2354287 (1)
1 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (24)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#114500 Colorectal cancer; crc P84022
Q14191
#612219 Ewing sarcoma; es P11308
#600274 Frontotemporal dementia; ftd P10636
#606764 Gastrointestinal stromal tumor; gist P10721
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#601626 Leukemia, acute myeloid; aml P10721
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#612371 Major affective disorder 7; mafd7 P17861
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#601358 Nicolaides-baraitser syndrome; ncbrs P51531
#601665 Obesity P32245
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#172800 Piebald trait; pbt P10721
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#273300 Testicular germ cell tumor; tgct P10721
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (22)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00003 Acute myeloid leukemia (AML) P10721 (related)
P10721 (marker)
H00170 Piebaldism P10721 (related)
H00023 Testicular cancer P10721 (marker)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)