PCIDB

KNApSAcK Metabolite C00040807

Metabolite

KNApSAcK Entry

id C00040807
Name 28-Deoxonimbolide
CAS RN 126005-94-5
Standard InChI InChI=1S/C27H32O6/c1-14-16(15-7-9-31-12-15)10-17-21(14)27(4)18(11-20(29)30-5)26(3)19(28)6-8-25(2)13-32-22(23(25)26)24(27)33-17/h6-9,12,16-18,22-24H,10-11,13H2,1-5H3/t16-,17-,18-,22-,23+,24-,25+,26+,27-/m1/s1
Standard InChI (Main Layer) InChI=1S/C27H32O6/c1-14-16(15-7-9-31-12-15)10-17-21(14)27(4)18(11-20(29)30-5)26(3)19(28)6-8-25(2)13-32-22(23(25)26)24(27)33-17/h6-9,12,16-18,22-24H,10-11,13H2,1-5H3

Cluster

Phytochemical cluster
KCF-S cluster No. 2762

Link

ChEMBL

By standard InChI CHEMBL485455
By standard InChI Main Layer CHEMBL485455

KEGG

By LinkDB

CTD

By CAS RN C062897

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Meliaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Owenia cepiodora 43707 Meliaceae rosids Viridiplantae

Human Protein / Gene in interaction

CTD interaction (3)

compound gene gene name gene description interaction interaction type form reference
pmid
C062897 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) 28-deoxonimbolide results in increased activity of CASP3 protein increases activity
protein 21381696
C062897 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) 28-deoxonimbolide results in increased activity of CASP8 protein increases activity
protein 21381696
C062897 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) 28-deoxonimbolide results in increased activity of CASP9 protein increases activity
protein 21381696

Related Disease

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D007938 C062897 Leukemia therapeutic
21381696