KNApSAcK Metabolite C00043397
Metabolite
KNApSAcK Entry
| id | C00043397 |
|---|---|
| Name | Clavulone II |
| CAS RN | 85700-43-2 |
| Standard InChI | InChI=1S/C25H34O7/c1-5-6-7-8-9-10-17-25(32-20(3)27)18-16-23(28)22(25)13-11-12-21(31-19(2)26)14-15-24(29)30-4/h9-13,16,18,21H,5-8,14-15,17H2,1-4H3/b10-9-,12-11+,22-13-/t21-,25-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C25H34O7/c1-5-6-7-8-9-10-17-25(32-20(3)27)18-16-23(28)22(25)13-11-12-21(31-19(2)26)14-15-24(29)30-4/h9-13,16,18,21H,5-8,14-15,17H2,1-4H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 659 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer |
KEGG
| By LinkDB | C13812 |
|---|
CTD
| By CAS RN | C057741 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Clavulariidae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Clavularia viridis | 153213 | Clavulariidae | Metazoa |
Human Protein / Gene in interaction
CTD interaction (7)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C057741 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | clavulone II results in increased expression of BAX protein |
increases expression
|
protein |
15920677
|
| C057741 | 637 |
BID
FP497 |
BH3 interacting domain death agonist | clavulone II results in increased cleavage of BID protein |
increases cleavage
|
protein |
15920677
|
| C057741 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | clavulone II results in increased activity of CASP3 protein |
increases activity
|
protein |
15920677
|
| C057741 | 841 |
CASP8
ALPS2B CAP4 Casp-8 FLICE MACH MCH5 |
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | clavulone II results in increased cleavage of and results in increased activity of CASP8 protein |
increases activity
/ increases cleavage |
protein |
15920677
|
| C057741 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | clavulone II results in increased cleavage of and results in increased activity of CASP9 protein |
increases activity
/ increases cleavage |
protein |
15920677
|
| C057741 | 595 |
CCND1
BCL1 D11S287E PRAD1 U21B31 |
cyclin D1 | clavulone II results in decreased expression of CCND1 protein |
decreases expression
|
protein |
15920677
|
| C057741 | 4170 |
MCL1
BCL2L3 EAT MCL1-ES MCL1L MCL1S Mcl-1 TM bcl2-L-3 mcl1/EAT |
myeloid cell leukemia sequence 1 (BCL2-related) | clavulone II results in decreased expression of MCL1 protein |
decreases expression
|
protein |
15920677
|