PCIDB

KNApSAcK Metabolite C00044435

Metabolite

KNApSAcK Entry

id C00044435
Name 3,5,4'-Trihydroxystilbene
CAS RN 133294-37-8
Standard InChI InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
Standard InChI (Main Layer) InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H

Cluster

Phytochemical cluster No. 13
KCF-S cluster No. 295

Link

ChEMBL

By standard InChI CHEMBL165
By standard InChI Main Layer CHEMBL165 CHEMBL87333 CHEMBL2019155

KEGG

By LinkDB C03582

CTD

By CAS RN

Species

Summary

Plant class

class name count
eudicotyledons 1

Family

family name count
Polygonaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Rumex bucephalophorus 242533 Polygonaceae eudicotyledons Viridiplantae

Human Protein / Gene in interaction

179 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL165 CHEMBL87333 CHEMBL1614110 (2) CHEMBL1741321 (2)
CHEMBL1909136 (2)
1 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme CHEMBL165 CHEMBL1613805 (1) CHEMBL1614293 (1)
0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr CHEMBL165 CHEMBL953268 (1)
0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL165 CHEMBL87333 CHEMBL1613992 (4) CHEMBL1613995 (3)
CHEMBL1738132 (1)
7 / 44
Q16637 Survival motor neuron protein Unclassified protein CHEMBL165 CHEMBL87333 CHEMBL1613842 (5)
4 / 2
Q99700 Ataxin-2 Unclassified protein CHEMBL165 CHEMBL1794367 (1) CHEMBL2114784 (1)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL165 CHEMBL1794499 (1)
2 / 0
P14618 Pyruvate kinase PKM Enzyme CHEMBL87333 CHEMBL1614177 (1) CHEMBL1614265 (1)
0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL165 CHEMBL1909139 (2)
0 / 0
P27338 Amine oxidase [flavin-containing] B Oxidoreductase CHEMBL87333 CHEMBL1059215 (1)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL165 CHEMBL869264 (1) CHEMBL868097 (1)
CHEMBL906707 (1) CHEMBL932255 (1)
CHEMBL1020816 (1) CHEMBL941537 (1)
CHEMBL1008495 (1) CHEMBL1176361 (1)
CHEMBL1176362 (1) CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL165 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL165 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL165 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL165 CHEMBL1909201 (2)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL165 CHEMBL1614079 (1)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL165 CHEMBL1909176 (2)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL165 CHEMBL1614076 (1)
1 / 1
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase CHEMBL165 CHEMBL2019155 CHEMBL1227478 (1) CHEMBL2019846 (1)
0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase CHEMBL165 CHEMBL2019155 CHEMBL1227477 (1) CHEMBL2019852 (1)
0 / 0
P43166 Carbonic anhydrase 7 Lyase CHEMBL165 CHEMBL2019155 CHEMBL1227480 (1) CHEMBL2019848 (1)
0 / 0
P29466 Caspase-1 C14 CHEMBL165 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL165 CHEMBL1821182 (1) CHEMBL1821183 (1)
CHEMBL1821184 (1) CHEMBL1821186 (1)
CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL165 CHEMBL1909199 (2)
0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL165 CHEMBL1794524 (1) CHEMBL1794552 (1)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL165 CHEMBL1909197 (2)
2 / 2
Q8N1Q1 Carbonic anhydrase 13 Lyase CHEMBL165 CHEMBL2019155 CHEMBL1227626 (1) CHEMBL2019849 (1)
0 / 0
P28907 ADP-ribosyl cyclase 1 Enzyme CHEMBL165 CHEMBL1799589 (1)
0 / 1
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL87333 CHEMBL1614331 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL165 CHEMBL87333 CHEMBL1614310 (1) CHEMBL1614544 (3)
11 / 10
P55789 FAD-linked sulfhydryl oxidase ALR Enzyme CHEMBL165 CHEMBL1738573 (1)
1 / 0
P09960 Leukotriene A-4 hydrolase M1 CHEMBL165 CHEMBL1032963 (1) CHEMBL1032964 (1)
0 / 0
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL165 CHEMBL1613776 (1)
3 / 1
P00918 Carbonic anhydrase 2 Lyase CHEMBL165 CHEMBL2019155 CHEMBL1227474 (1) CHEMBL1909123 (2)
CHEMBL2019838 (1)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL165 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL165 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL165 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL165 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL165 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL165 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL165 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL165 CHEMBL1909093 (2)
0 / 0
P02768 Serum albumin Secreted protein CHEMBL165 CHEMBL953986 (1) CHEMBL953987 (1)
CHEMBL953988 (1)
0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 CHEMBL165 CHEMBL1743521 (1)
0 / 0
P08183 Multidrug resistance protein 1 drug CHEMBL165 CHEMBL861699 (1) CHEMBL861700 (1)
1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL165 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL165 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL165 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL165 CHEMBL87333 CHEMBL1614027 (3) CHEMBL1741325 (2)
CHEMBL1909135 (2)
0 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL165 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL165 CHEMBL1614166 (1)
1 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL165 CHEMBL1909203 (2)
1 / 11
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL165 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL165 CHEMBL863436 (1) CHEMBL866165 (1)
CHEMBL868097 (1) CHEMBL932254 (1)
CHEMBL1020815 (1) CHEMBL941536 (1)
CHEMBL1008496 (1) CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL165 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL165 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL165 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL165 CHEMBL1909214 (2)
0 / 0
P11926 Ornithine decarboxylase Lyase CHEMBL165 CHEMBL970064 (1)
0 / 0
P23280 Carbonic anhydrase 6 Lyase CHEMBL165 CHEMBL2019155 CHEMBL1227479 (1) CHEMBL2019847 (1)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL165 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL165 CHEMBL1909096 (2)
1 / 1
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL165 CHEMBL1613800 (1)
0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL165 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL165 CHEMBL1909166 (2)
1 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase CHEMBL165 CHEMBL2019155 CHEMBL1227627 (1) CHEMBL2019850 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL165 CHEMBL87333 CHEMBL1614458 (7)
0 / 0
O43570 Carbonic anhydrase 12 Lyase CHEMBL165 CHEMBL2019155 CHEMBL1227625 (1) CHEMBL2019842 (1)
1 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL165 CHEMBL1909133 (2)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL165 CHEMBL87333 CHEMBL1614456 (3) CHEMBL1613803 (3)
0 / 0
Q8IXJ6 NAD-dependent protein deacetylase sirtuin-2 Enzyme CHEMBL165 CHEMBL933818 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL87333 CHEMBL1738606 (1)
0 / 0
Q12778 Forkhead box protein O1 Unclassified protein CHEMBL165 CHEMBL2353207 (1)
1 / 2
P42858 Huntingtin Unclassified protein CHEMBL165 CHEMBL1614147 (1)
1 / 1
O75496 Geminin Unclassified protein CHEMBL165 CHEMBL2114843 (1)
0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL165 CHEMBL1613838 (2)
0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme CHEMBL165 CHEMBL2114807 (1)
4 / 2
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL165 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL165 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL165 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL165 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL165 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL165 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL165 CHEMBL1647075 (1) CHEMBL1647190 (1)
CHEMBL1647194 (1) CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL165 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL165 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL165 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL165 CHEMBL1909167 (2)
1 / 0
P00915 Carbonic anhydrase 1 Lyase CHEMBL165 CHEMBL2019155 CHEMBL1227473 (1) CHEMBL2019836 (1)
0 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL165 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL165 CHEMBL1909194 (2)
0 / 0
P07711 Cathepsin L1 C1A CHEMBL165 CHEMBL1614088 (1)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL165 CHEMBL1909110 (2)
1 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL165 CHEMBL2114788 (1)
0 / 0
P03956 Interstitial collagenase M10A CHEMBL165 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL165 CHEMBL1909119 (2)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL165 CHEMBL1738610 (1)
0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL165 CHEMBL1794423 (1) CHEMBL1963893 (1)
0 / 0
Q9NZ45 CDGSH iron-sulfur domain-containing protein 1 Unclassified protein CHEMBL165 CHEMBL1826573 (1)
0 / 0
P01106 Myc proto-oncogene protein Unclassified protein CHEMBL165 CHEMBL2353443 (1) CHEMBL2353444 (1)
1 / 15
P04150 Glucocorticoid receptor NR3C1 CHEMBL165 CHEMBL1794382 (2) CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL165 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL165 CHEMBL1909170 (2)
0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 CHEMBL165 CHEMBL87333 CHEMBL949646 (1) CHEMBL960910 (1)
CHEMBL1176011 (1) CHEMBL1941244 (2)
CHEMBL1941245 (2) CHEMBL1961307 (1)
CHEMBL1961308 (1) CHEMBL2213354 (1)
CHEMBL2213355 (1)
2 / 2
P14679 Tyrosinase Oxidoreductase CHEMBL165 CHEMBL1013463 (1) CHEMBL1780390 (1)
4 / 2
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL165 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL165 CHEMBL1909109 (2)
2 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL165 CHEMBL1794293 (1) CHEMBL1794510 (2)
5 / 3
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL165 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL165 CHEMBL1909172 (2)
1 / 0
P16083 Ribosyldihydronicotinamide dehydrogenase [quinone] Enzyme CHEMBL165 CHEMBL960909 (1) CHEMBL1065027 (1)
CHEMBL1109212 (1) CHEMBL1693919 (1)
0 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL165 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL165 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL165 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL165 CHEMBL1909108 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL165 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL165 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL165 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL165 CHEMBL87333 CHEMBL1741322 (2) CHEMBL1909132 (2)
0 / 0
Q16790 Carbonic anhydrase 9 Lyase CHEMBL165 CHEMBL2019155 CHEMBL1228226 (1) CHEMBL2019840 (1)
0 / 1
Q9NTG7 NAD-dependent protein deacetylase sirtuin-3, mitochondrial Enzyme CHEMBL165 CHEMBL933819 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL165 CHEMBL87333 CHEMBL1613910 (4) CHEMBL1614227 (5)
3 / 3
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL165 CHEMBL1006005 (1)
1 / 1
O43524 Forkhead box protein O3 Unclassified protein CHEMBL165 CHEMBL946591 (1) CHEMBL946592 (1)
CHEMBL948616 (1) CHEMBL948620 (1)
CHEMBL948623 (1)
0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL165 CHEMBL87333 CHEMBL1614038 (7)
2 / 2
O15118 Niemann-Pick C1 protein Unclassified protein CHEMBL165 CHEMBL1614342 (2)
1 / 1
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL165 CHEMBL1614171 (1)
5 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL165 CHEMBL2114842 (1)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL165 CHEMBL1738588 (1) CHEMBL1738675 (1)
CHEMBL1737868 (1) CHEMBL1738317 (1)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL165 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL165 CHEMBL829990 (1) CHEMBL1647192 (1)
CHEMBL1647195 (1) CHEMBL1794364 (2)
CHEMBL1794542 (2) CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL165 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL165 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL165 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL165 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL165 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL165 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL165 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL165 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL165 CHEMBL1909168 (2)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL87333 CHEMBL1614240 (1)
0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt CHEMBL165 CHEMBL948617 (1) CHEMBL948618 (1)
CHEMBL948621 (1)
4 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL165 CHEMBL87333 CHEMBL1613777 (2) CHEMBL1741323 (2)
CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL165 CHEMBL87333 CHEMBL1614108 (4) CHEMBL1613886 (4)
CHEMBL1741324 (2) CHEMBL1743448 (1)
CHEMBL1743460 (2) CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL165 CHEMBL1909137 (2)
0 / 0
Q96EB6 NAD-dependent protein deacetylase sirtuin-1 Enzyme CHEMBL165 CHEMBL933817 (2) CHEMBL933820 (1)
CHEMBL930181 (1) CHEMBL995952 (1)
CHEMBL995953 (1) CHEMBL999423 (1)
CHEMBL999424 (1) CHEMBL2345564 (1)
CHEMBL2345566 (1) CHEMBL2345569 (1)
CHEMBL2343193 (1) CHEMBL2343194 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL165 CHEMBL1794483 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL165 CHEMBL87333 CHEMBL1614211 (2)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL165 CHEMBL87333 CHEMBL1614250 (2) CHEMBL1614421 (6)
CHEMBL1614502 (6)
4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL165 CHEMBL1738402 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL165 CHEMBL1737980 (1) CHEMBL2114890 (2)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL165 CHEMBL1794321 (1) CHEMBL1794560 (2)
3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL165 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL165 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL165 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL165 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL165 CHEMBL1909116 (2)
1 / 1
P07451 Carbonic anhydrase 3 Lyase CHEMBL165 CHEMBL2019155 CHEMBL1227475 (1) CHEMBL2019844 (1)
0 / 0
P06239 Tyrosine-protein kinase Lck Src CHEMBL165 CHEMBL765997 (1) CHEMBL1909206 (2)
0 / 1
P35869 Aryl hydrocarbon receptor Transcription Factor CHEMBL165 CHEMBL1647069 (1) CHEMBL1647070 (1)
CHEMBL2114849 (2)
0 / 0
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL165 CHEMBL1909128 (2)
0 / 0
P22748 Carbonic anhydrase 4 Lyase CHEMBL165 CHEMBL2019155 CHEMBL1227476 (1) CHEMBL2019845 (1)
1 / 1
Q07817 Bcl-2-like protein 1 Other cytosolic protein CHEMBL165 CHEMBL1107439 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL165 CHEMBL87333 CHEMBL1794536 (2)
0 / 0
P11169 Solute carrier family 2, facilitated glucose transporter member 3 Unclassified protein CHEMBL165 CHEMBL940498 (1) CHEMBL940499 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL165 CHEMBL87333 CHEMBL1613914 (6)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL87333 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL165 CHEMBL1738442 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL87333 CHEMBL1614364 (1)
1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL165 CHEMBL2354311 (1)
1 / 0
O00255 Menin Unclassified protein CHEMBL165 CHEMBL87333 CHEMBL1614257 (6)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL165 CHEMBL87333 CHEMBL1614257 (6)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL165 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL165 CHEMBL1613933 (1)
1 / 6
P00519 Tyrosine-protein kinase ABL1 Abl CHEMBL165 CHEMBL861701 (1) CHEMBL861702 (1)
1 / 4
P11274 Breakpoint cluster region protein Bcr CHEMBL165 CHEMBL861701 (1) CHEMBL861702 (1)
1 / 4
Q00653 Nuclear factor NF-kappa-B p100 subunit Transcription Factor CHEMBL165 CHEMBL1613870 (1)
0 / 0
Q04206 Transcription factor p65 Transcription Factor CHEMBL165 CHEMBL1613870 (1)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL165 CHEMBL1613870 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (114)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#210900 Bloom syndrome; blm P54132
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#114480 Breast cancer P31749
P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#300615 Brunner syndrome P21397
#113970 Burkitt lymphoma; bl P01106
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P31749
#615109 Cowden syndrome 6; cws6 P31749
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
P37231
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#608232 Leukemia, chronic myeloid; cml P00519
P11274
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#613076 Myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay P55789
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#176920 Proteus syndrome P31749
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#268220 Rhabdomyosarcoma 2; rms2 Q12778
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (101)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P04637 (marker)
Q16790 (marker)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) P00519 (related)
P00519 (marker)
P01106 (related)
P01106 (marker)
P11274 (related)
P11274 (marker)
Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00004 Chronic myeloid leukemia (CML) P00519 (related)
P00519 (marker)
P04637 (related)
P11274 (related)
P11274 (marker)
Q01196 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P01106 (related)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P01106 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P01106 (related)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) P01106 (related)
Q03164 (related)
H00008 Burkitt lymphoma P01106 (related)
P01106 (marker)
P04637 (related)
H00010 Multiple myeloma P01106 (related)
P04637 (related)
H00013 Small cell lung cancer P01106 (related)
P04637 (related)
H00025 Penile cancer P01106 (related)
P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00027 Ovarian cancer P01106 (related)
P04626 (related)
P04637 (related)
P38398 (related)
H00031 Breast cancer P01106 (related)
P04626 (related)
P04626 (marker)
P04637 (related)
P38398 (related)
H00036 Osteosarcoma P01106 (related)
P04637 (related)
P08684 (marker)
H00041 Kaposi's sarcoma P01106 (related)
P04637 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
P28907 (marker)
H00006 Hairy-cell leukemia P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00548 Brunner syndrome P21397 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00059 Huntington's disease (HD) P42858 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00037 Alveolar rhabdomyosarcoma Q12778 (related)
Q12778 (marker)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)