KNApSAcK Metabolite C00044726
Metabolite
KNApSAcK Entry
| id | C00044726 |
|---|---|
| Name | Dolastatin 10 / (-)-Dolastatin 10 |
| CAS RN | 110417-88-4 |
| Standard InChI | InChI=1S/C42H68N6O6S/c1-13-28(6)37(47(10)42(52)35(26(2)3)45-40(51)36(27(4)5)46(8)9)33(53-11)25-34(49)48-22-17-20-32(48)38(54-12)29(7)39(50)44-31(41-43-21-23-55-41)24-30-18-15-14-16-19-30/h14-16,18-19,21,23,26-29,31-33,35-38H,13,17,20,22,24-25H2,1-12H3,(H,44,50)(H,45,51)/t28-,29+,31-,32-,33+,35-,36-,37-,38+/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C42H68N6O6S/c1-13-28(6)37(47(10)42(52)35(26(2)3)45-40(51)36(27(4)5)46(8)9)33(53-11)25-34(49)48-22-17-20-32(48)38(54-12)29(7)39(50)44-31(41-43-21-23-55-41)24-30-18-15-14-16-19-30/h14-16,18-19,21,23,26-29,31-33,35-38H,13,17,20,22,24-25H2,1-12H3,(H,44,50)(H,45,51) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 2420 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL106850 CHEMBL322390 CHEMBL108116 CHEMBL104543 CHEMBL432610 CHEMBL325114 CHEMBL321425 CHEMBL319657 CHEMBL321271 CHEMBL321910 CHEMBL321911 CHEMBL320475 CHEMBL431233 CHEMBL1713020 CHEMBL1980788 CHEMBL2111674 CHEMBL2111675 CHEMBL2111676 CHEMBL2111677 CHEMBL2111678 |
KEGG
| By LinkDB | C11280 |
|---|
CTD
| By CAS RN | C064570 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Aplysiidae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Dolabella auricularia | 6511 | Aplysiidae | Metazoa |
Human Protein / Gene in interaction
6 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q99700 | Ataxin-2 | Unclassified protein | CHEMBL1713020 |
CHEMBL2114784
(1)
|
1 / 1 |
| O75496 | Geminin | Unclassified protein | CHEMBL1713020 |
CHEMBL2114780
(1)
|
0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | CHEMBL1713020 |
CHEMBL2114810
(1)
|
7 / 3 |
| P51843 | Nuclear receptor subfamily 0 group B member 1 | Nuclear hormone receptor subfamily 0 group B member 1 | CHEMBL1713020 |
CHEMBL2354292
(1)
|
2 / 2 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL1713020 |
CHEMBL1738184
(1)
|
0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | CHEMBL1713020 |
CHEMBL2354311
(1)
|
1 / 0 |
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (11)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300018 | 46,xy sex reversal 2; srxy2 |
P51843
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #300200 | Adrenal hypoplasia, congenital; ahc |
P51843
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
KEGG DISEASE (6)
| KEGG | disease name | UniProt |
|---|---|---|
| H00552 | Glycerol kinase deficiency (GKD) |
P51843
(related)
|
| H00607 | 46,XY disorders of sex development (Disorders of gonadal development) |
P51843
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|