KNApSAcK Metabolite C00047241
Metabolite
KNApSAcK Entry
| id | C00047241 |
|---|---|
| Name | Guggulsterone |
| CAS RN | 95975-55-6 |
| Standard InChI | InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 3702 |
Link
ChEMBL
| By standard InChI | CHEMBL410683 |
|---|---|
| By standard InChI Main Layer | CHEMBL372106 CHEMBL402063 CHEMBL410683 CHEMBL1452876 CHEMBL1514005 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN | C023617 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 1 |
Family
| family name | count |
|---|---|
| Burseraceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Commiphora mukul | 43868 | Burseraceae | rosids | Viridiplantae |
Human Protein / Gene in interaction
41 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL1452876 |
CHEMBL1741321
(1)
|
1 / 0 |
| O75469 | Nuclear receptor subfamily 1 group I member 2 | NR1I2 | CHEMBL402063 CHEMBL410683 |
CHEMBL880930
(2)
|
0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | CHEMBL402063 |
CHEMBL1613992
(1)
|
7 / 44 |
| Q16637 | Survival motor neuron protein | Unclassified protein | CHEMBL372106 CHEMBL402063 CHEMBL410683 CHEMBL1514005 |
CHEMBL1613842
(4)
|
4 / 2 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | CHEMBL402063 CHEMBL410683 |
CHEMBL1794573
(2)
|
2 / 2 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | CHEMBL402063 CHEMBL410683 |
CHEMBL1794524
(2)
CHEMBL1794552
(2)
|
0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | CHEMBL402063 |
CHEMBL1614281
(1)
CHEMBL1614361
(1)
|
3 / 2 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | CHEMBL402063 CHEMBL410683 |
CHEMBL1794399
(2)
|
3 / 1 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | CHEMBL402063 CHEMBL410683 |
CHEMBL1794371
(2)
CHEMBL1794471
(2)
|
0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL1452876 |
CHEMBL1614027
(1)
CHEMBL1741325
(1)
|
0 / 1 |
| P54132 | Bloom syndrome protein | Enzyme | CHEMBL372106 |
CHEMBL1614522
(1)
CHEMBL1614067
(1)
|
1 / 2 |
| P11473 | Vitamin D3 receptor | NR1I1 | CHEMBL372106 CHEMBL402063 CHEMBL410683 CHEMBL1514005 |
CHEMBL1794311
(2)
CHEMBL1794376
(1)
CHEMBL1794339 (2) |
2 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL402063 CHEMBL410683 |
CHEMBL1614458
(2)
|
0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | CHEMBL410683 |
CHEMBL1614399
(1)
|
0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | CHEMBL402063 |
CHEMBL2114835
(1)
|
0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | CHEMBL402063 CHEMBL410683 |
CHEMBL884753
(2)
CHEMBL881886
(2)
CHEMBL1794382 (2) CHEMBL1794456 (1) |
0 / 1 |
| P06401 | Progesterone receptor | NR3C3 | CHEMBL402063 CHEMBL410683 |
CHEMBL884754
(2)
CHEMBL881889
(2)
|
0 / 1 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | CHEMBL402063 CHEMBL410683 |
CHEMBL1794293
(1)
CHEMBL1794510
(2)
|
5 / 3 |
| Q96RI1 | Bile acid receptor | NR1H4 | CHEMBL402063 CHEMBL410683 |
CHEMBL884750
(2)
CHEMBL881762
(2)
CHEMBL906990 (1) CHEMBL892389 (1) CHEMBL892390 (1) CHEMBL892393 (1) CHEMBL943880 (1) CHEMBL1027008 (1) CHEMBL1027009 (1) CHEMBL1671292 (1) CHEMBL1794415 (2) CHEMBL1794437 (1) CHEMBL2176594 (1) CHEMBL2176595 (1) |
0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | CHEMBL402063 |
CHEMBL1613808
(1)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL1452876 |
CHEMBL1741322
(1)
|
0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | CHEMBL1452876 |
CHEMBL1614227
(1)
|
3 / 3 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | CHEMBL372106 |
CHEMBL1614171
(1)
|
5 / 2 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | CHEMBL402063 CHEMBL410683 |
CHEMBL2114842
(2)
|
0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | CHEMBL402063 CHEMBL410683 |
CHEMBL884740
(2)
CHEMBL881778
(2)
CHEMBL1794364 (2) CHEMBL1794542 (2) |
1 / 1 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | CHEMBL402063 |
CHEMBL2114853
(1)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL1452876 |
CHEMBL1613777
(1)
CHEMBL1741323
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL402063 CHEMBL410683 CHEMBL1452876 |
CHEMBL1614108
(2)
CHEMBL1613886
(2)
CHEMBL1741324 (1) CHEMBL1743290 (1) |
0 / 1 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | CHEMBL372106 |
CHEMBL1614052
(1)
|
1 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | CHEMBL372106 CHEMBL1514005 |
CHEMBL1614421
(3)
|
4 / 3 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL402063 CHEMBL410683 |
CHEMBL2114890
(2)
|
0 / 0 |
| P08235 | Mineralocorticoid receptor | NR3C2 | CHEMBL402063 CHEMBL410683 |
CHEMBL872346
(2)
CHEMBL881399
(2)
|
2 / 2 |
| P10275 | Androgen receptor | NR3C4 | CHEMBL402063 CHEMBL410683 |
CHEMBL884739
(2)
CHEMBL881777
(2)
CHEMBL1794560 (2) |
3 / 4 |
| P04054 | Phospholipase A2 | Enzyme | CHEMBL410683 |
CHEMBL1026212
(1)
CHEMBL1026996
(1)
|
0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | CHEMBL1452876 |
CHEMBL1614086
(1)
CHEMBL1614034
(1)
|
1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL372106 |
CHEMBL1738442
(1)
|
0 / 0 |
| O00255 | Menin | Unclassified protein | CHEMBL372106 |
CHEMBL1614257
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL372106 |
CHEMBL1614257
(1)
|
1 / 3 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | CHEMBL402063 |
CHEMBL1613933
(1)
|
0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | CHEMBL402063 |
CHEMBL1613933
(1)
|
1 / 6 |
| Q92731 | Estrogen receptor beta | NR3A2 | CHEMBL402063 CHEMBL410683 |
CHEMBL884740
(2)
CHEMBL881778
(2)
|
0 / 1 |
CTD interaction (71)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C023617 | 8647 |
ABCB11
ABC16 BRIC2 BSEP PFIC-2 PFIC2 PGY4 SPGP |
ATP-binding cassette, sub-family B (MDR/TAP), member 11 | [pregna-4,17-diene-3,16-dione co-treated with Chenodeoxycholic Acid] results in increased expression of ABCB11 mRNA |
affects cotreatment
/ increases expression |
mRNA |
12525500
|
| C023617 | 8647 |
ABCB11
ABC16 BRIC2 BSEP PFIC-2 PFIC2 PGY4 SPGP |
ATP-binding cassette, sub-family B (MDR/TAP), member 11 | [pregna-4,17-diene-3,16-dione co-treated with GW 4064] results in increased expression of ABCB11 mRNA |
affects cotreatment
/ increases expression |
mRNA |
12525500
|
| C023617 | 8647 |
ABCB11
ABC16 BRIC2 BSEP PFIC-2 PFIC2 PGY4 SPGP |
ATP-binding cassette, sub-family B (MDR/TAP), member 11 | pregna-4,17-diene-3,16-dione inhibits the reaction [Bile Acids and Salts results in increased expression of ABCB11 mRNA] |
decreases reaction
/ increases expression |
mRNA |
12705905
|
| C023617 | 8647 |
ABCB11
ABC16 BRIC2 BSEP PFIC-2 PFIC2 PGY4 SPGP |
ATP-binding cassette, sub-family B (MDR/TAP), member 11 | pregna-4,17-diene-3,16-dione inhibits the reaction [NR1H4 protein results in increased expression of ABCB11 mRNA] |
decreases reaction
/ increases expression |
mRNA |
12705905
|
| C023617 | 8647 |
ABCB11
ABC16 BRIC2 BSEP PFIC-2 PFIC2 PGY4 SPGP |
ATP-binding cassette, sub-family B (MDR/TAP), member 11 | pregna-4,17-diene-3,16-dione results in increased expression of ABCB11 mRNA |
increases expression
|
mRNA |
12525500
|
| C023617 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
15322087
|
| C023617 | 597 |
BCL2A1
ACC-1 ACC-2 BCL2L5 BFL1 GRS HBPA1 |
BCL2-related protein A1 | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
15322087
|
| C023617 | 637 |
BID
FP497 |
BH3 interacting domain death agonist | pregna-4,17-diene-3,16-dione results in increased cleavage of BID protein |
increases cleavage
|
protein |
17475222
|
| C023617 | 329 |
BIRC2
API1 HIAP2 Hiap-2 MIHB RNF48 c-IAP1 cIAP1 |
baculoviral IAP repeat containing 2 | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
15322087
|
| C023617 | 332 |
BIRC5
API4 EPR-1 |
baculoviral IAP repeat containing 5 | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BIRC5 mRNA] |
decreases reaction
/ increases expression |
mRNA |
15322087
|
| C023617 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | pregna-4,17-diene-3,16-dione results in increased activity of CASP3 protein |
increases activity
|
protein |
17475222
|
| C023617 | 841 |
CASP8
ALPS2B CAP4 Casp-8 FLICE MACH MCH5 |
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | pregna-4,17-diene-3,16-dione results in increased activity of CASP8 protein |
increases activity
|
protein |
17475222
|
| C023617 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | pregna-4,17-diene-3,16-dione results in increased activity of CASP9 protein |
increases activity
|
protein |
17475222
|
| C023617 | 874 |
CBR3
SDR21C2 hCBR3 |
carbonyl reductase 3 (EC:1.1.1.184) | pregna-4,17-diene-3,16-dione results in increased expression of CBR3 mRNA |
increases expression
|
mRNA |
20806931
|
| C023617 | 595 |
CCND1
BCL1 D11S287E PRAD1 U21B31 |
cyclin D1 | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
15322087
|
| C023617 | 595 |
CCND1
BCL1 D11S287E PRAD1 U21B31 |
cyclin D1 | pregna-4,17-diene-3,16-dione results in decreased expression of CCND1 protein |
decreases expression
|
protein |
17475222
|
| C023617 | 983 |
CDK1
CDC2 CDC28A P34CDC2 |
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) | pregna-4,17-diene-3,16-dione results in decreased expression of CDK1 protein |
decreases expression
|
protein |
17475222
|
| C023617 | 1026 |
CDKN1A
CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1 |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) | pregna-4,17-diene-3,16-dione results in increased expression of CDKN1A protein |
increases expression
|
protein |
17475222
|
| C023617 | 1027 |
CDKN1B
CDKN4 KIP1 MEN1B MEN4 P27KIP1 |
cyclin-dependent kinase inhibitor 1B (p27, Kip1) | pregna-4,17-diene-3,16-dione results in increased expression of CDKN1B protein |
increases expression
|
protein |
17475222
|
| C023617 | 8837 |
CFLAR
CASH CASP8AP1 CLARP Casper FLAME FLAME-1 FLAME1 FLIP I-FLICE MRIT c-FLIP c-FLIPL c-FLIPR c-FLIPS |
CASP8 and FADD-like apoptosis regulator | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA] |
decreases reaction
/ increases expression |
mRNA |
15322087
|
| C023617 | 1537 |
CYC1
MC3DN6 UQCR4 |
cytochrome c-1 | pregna-4,17-diene-3,16-dione affects the localization of CYC1 protein |
affects localization
|
protein |
17475222
|
| C023617 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | pregna-4,17-diene-3,16-dione results in increased expression of CYP3A4 mRNA |
increases expression
|
mRNA |
15075359
|
| C023617 | 1581 |
CYP7A1
CP7A CYP7 CYPVII |
cytochrome P450, family 7, subfamily A, polypeptide 1 (EC:1.14.13.17) | pregna-4,17-diene-3,16-dione inhibits the reaction [NR1I2 protein results in increased expression of CYP7A1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
12705905
|
| C023617 | 2729 |
GCLC
GCL GCS GLCL GLCLC |
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) | pregna-4,17-diene-3,16-dione results in increased expression of GCLC mRNA |
increases expression
|
mRNA |
22851183
|
| C023617 | 2730 |
GCLM
GLCLR |
glutamate-cysteine ligase, modifier subunit (EC:6.3.2.2) | pregna-4,17-diene-3,16-dione results in increased expression of GCLM mRNA |
increases expression
|
mRNA |
22851183
|
| C023617 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | pregna-4,17-diene-3,16-dione inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein] |
decreases reaction
/ increases activity |
protein |
15322087
|
| C023617 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | pregna-4,17-diene-3,16-dione inhibits the reaction [IL1B protein results in increased activity of RELA protein] |
decreases reaction
/ increases activity |
protein |
15322087
|
| C023617 | 5599 |
MAPK8
JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c |
mitogen-activated protein kinase 8 (EC:2.7.11.24) | pregna-4,17-diene-3,16-dione results in increased activity of MAPK8 protein |
increases activity
|
protein |
17475222
|
| C023617 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA] |
decreases reaction
/ increases expression |
mRNA |
15322087
|
| C023617 | 4609 |
MYC
MRTL MYCC bHLHe39 c-Myc |
v-myc avian myelocytomatosis viral oncogene homolog | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of MYC mRNA] |
decreases reaction
/ increases expression |
mRNA |
15322087
|
| C023617 | 4790 |
NFKB1
EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | pregna-4,17-diene-3,16-dione inhibits the reaction [Hydrogen Peroxide results in increased activity of NFKB1 protein] |
decreases reaction
/ increases activity |
protein |
15322087
|
| C023617 | 4790 |
NFKB1
EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | pregna-4,17-diene-3,16-dione inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein] |
decreases reaction
/ increases activity |
protein |
15322087
|
| C023617 | 4790 |
NFKB1
EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | pregna-4,17-diene-3,16-dione inhibits the reaction [Okadaic Acid results in increased activity of NFKB1 protein] |
decreases reaction
/ increases activity |
protein |
15322087
|
| C023617 | 4790 |
NFKB1
EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | pregna-4,17-diene-3,16-dione inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of NFKB1 protein] |
decreases reaction
/ increases activity |
protein |
15322087
|
| C023617 | 4790 |
NFKB1
EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] |
decreases reaction
/ increases activity |
protein |
15322087
|
| C023617 | 4792 |
NFKBIA
IKBA MAD-3 NFKBI |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] |
decreases reaction
/ increases degradation |
protein |
15322087
|
| C023617 | 4792 |
NFKBIA
IKBA MAD-3 NFKBI |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] |
decreases reaction
/ increases phosphorylation |
protein |
15322087
|
| C023617 | 1728 |
NQO1
DHQU DIA4 DTD NMOR1 NMORI QR1 |
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) | pregna-4,17-diene-3,16-dione results in increased expression of NQO1 mRNA |
increases expression
|
mRNA |
22851183
|
| C023617 | 9971 |
NR1H4
BAR FXR HRR-1 HRR1 RIP14 |
nuclear receptor subfamily 1, group H, member 4 | NR1H4 protein promotes the reaction [pregna-4,17-diene-3,16-dione results in increased abundance of Lipids] |
increases abundance
/ increases reaction |
protein |
20079722
|
| C023617 | 9971 |
NR1H4
BAR FXR HRR-1 HRR1 RIP14 |
nuclear receptor subfamily 1, group H, member 4 | pregna-4,17-diene-3,16-dione inhibits the reaction [NR1H4 protein results in increased expression of ABCB11 mRNA] |
decreases reaction
/ increases expression |
protein |
12705905
|
| C023617 | 8856 |
NR1I2
BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR |
nuclear receptor subfamily 1, group I, member 2 | pregna-4,17-diene-3,16-dione inhibits the reaction [NR1I2 protein results in increased expression of CYP7A1 mRNA] |
decreases reaction
/ increases expression |
protein |
12705905
|
| C023617 | 8856 |
NR1I2
BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR |
nuclear receptor subfamily 1, group I, member 2 | pregna-4,17-diene-3,16-dione results in decreased activity of NR1I2 protein |
decreases activity
|
protein |
12705905
|
| C023617 | 8856 |
NR1I2
BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR |
nuclear receptor subfamily 1, group I, member 2 | pregna-4,17-diene-3,16-dione results in increased activity of NR1I2 protein |
increases activity
|
protein |
15075359
|
| C023617 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
15322087
|
| C023617 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | pregna-4,17-diene-3,16-dione inhibits the reaction [Hydrogen Peroxide results in increased activity of RELA protein] |
decreases reaction
/ increases activity |
protein |
15322087
|
| C023617 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | pregna-4,17-diene-3,16-dione inhibits the reaction [IL1B protein results in increased activity of RELA protein] |
decreases reaction
/ increases activity |
protein |
15322087
|
| C023617 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | pregna-4,17-diene-3,16-dione inhibits the reaction [Okadaic Acid results in increased activity of RELA protein] |
decreases reaction
/ increases activity |
protein |
15322087
|
| C023617 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | pregna-4,17-diene-3,16-dione inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein] |
decreases reaction
/ increases activity |
protein |
15322087
|
| C023617 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased activity of RELA protein] |
decreases reaction
/ increases activity |
protein |
15322087
|
| C023617 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein] |
affects localization
/ decreases reaction / increases phosphorylation |
protein |
15322087
|
| C023617 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] |
decreases reaction
/ increases activity |
protein |
15322087
|
| C023617 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased activity of RELA protein] |
decreases reaction
/ increases activity |
protein |
15322087
|
| C023617 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] |
decreases reaction
/ increases degradation |
protein |
15322087
|
| C023617 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BCL2A1 mRNA] |
decreases reaction
/ increases expression |
protein |
15322087
|
| C023617 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA] |
decreases reaction
/ increases expression |
protein |
15322087
|
| C023617 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BIRC2 mRNA] |
decreases reaction
/ increases expression |
protein |
15322087
|
| C023617 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of BIRC5 mRNA] |
decreases reaction
/ increases expression |
protein |
15322087
|
| C023617 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA] |
decreases reaction
/ increases expression |
protein |
15322087
|
| C023617 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA] |
decreases reaction
/ increases expression |
protein |
15322087
|
| C023617 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA] |
decreases reaction
/ increases expression |
protein |
15322087
|
| C023617 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of MYC mRNA] |
decreases reaction
/ increases expression |
protein |
15322087
|
| C023617 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA] |
decreases reaction
/ increases expression |
protein |
15322087
|
| C023617 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA] |
decreases reaction
/ increases expression |
protein |
15322087
|
| C023617 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA] |
decreases reaction
/ increases expression |
protein |
15322087
|
| C023617 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of XIAP mRNA] |
decreases reaction
/ increases expression |
protein |
15322087
|
| C023617 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein] |
affects localization
/ decreases reaction / increases phosphorylation |
protein |
15322087
|
| C023617 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] |
decreases reaction
/ increases phosphorylation |
protein |
15322087
|
| C023617 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | pregna-4,17-diene-3,16-dione results in increased activity of TNF protein |
increases activity
|
protein |
15322087
|
| C023617 | 7185 |
TRAF1
EBI6 MGC:10353 |
TNF receptor-associated factor 1 | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of TRAF1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
15322087
|
| C023617 | 7422 |
VEGFA
MVCD1 VEGF VPF |
vascular endothelial growth factor A | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA] |
decreases reaction
/ increases expression |
mRNA |
15322087
|
| C023617 | 331 |
XIAP
API3 BIRC4 IAP-3 ILP1 MIHA XLP2 hIAP-3 hIAP3 |
X-linked inhibitor of apoptosis | pregna-4,17-diene-3,16-dione inhibits the reaction [TNF protein results in increased expression of XIAP mRNA] |
decreases reaction
/ increases expression |
mRNA |
15322087
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (53)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #210900 | Bloom syndrome; blm |
P54132
|
| %606641 | Body mass index; bmi |
P37231
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #605115 | Hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy |
P08235
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P04637
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #601665 | Obesity |
P37231
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #177735 | Pseudohypoaldosteronism, type i, autosomal dominant; pha1a |
P08235
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (76)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) P06401 (marker) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00243 | Hyperkalemic distal renal tubular acidosis (RTA type 4) |
P08235
(related)
|
| H00603 | Hypertension exacerbated in pregnancy |
P08235
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
Q01453
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
Q16637 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
12 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D050197 | C023617 | Atherosclerosis |
therapeutic
|
17475222
|
|
| D001943 | C023617 | Breast Neoplasms |
therapeutic
|
17475222
|
|
| D002283 | C023617 | Carcinoma, Bronchogenic |
therapeutic
|
17475222
|
|
| C535575 | C023617 | Carcinoma, squamous cell of head and neck |
therapeutic
|
17475222
|
|
| D003920 | C023617 | Diabetes Mellitus |
therapeutic
|
17475222
|
|
| D006949 | C023617 | Hyperlipidemias |
therapeutic
|
17475222
|
|
| D007938 | C023617 | Leukemia |
therapeutic
|
17475222
|
|
| D008545 | C023617 | Melanoma |
therapeutic
|
17475222
|
|
| D009101 | C023617 | Multiple Myeloma |
therapeutic
|
17475222
|
|
| D009765 | C023617 | Obesity |
therapeutic
|
17475222
|
|
| D010003 | C023617 | Osteoarthritis |
therapeutic
|
17475222
|
|
| D010051 | C023617 | Ovarian Neoplasms |
therapeutic
|
17475222
|