PCIDB

KNApSAcK Metabolite C00007266

Metabolite

KNApSAcK Entry

id C00007266
Name Hydrogen sulfide
CAS RN 7783-06-4
Standard InChI InChI=1S/H2S/h1H2
Standard InChI (Main Layer) InChI=1S/H2S/h1H2

Cluster

Phytochemical cluster
KCF-S cluster No. 8942

Link

ChEMBL

By standard InChI CHEMBL1200739
By standard InChI Main Layer CHEMBL38703 CHEMBL1200739

KEGG

By LinkDB C00283

CTD

By CAS RN D006862

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Brassicaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae

Human Protein / Gene in interaction

8 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P43166 Carbonic anhydrase 7 Lyase CHEMBL38703 CHEMBL860093 (1)
0 / 0
P00918 Carbonic anhydrase 2 Lyase CHEMBL38703 CHEMBL1200739 CHEMBL875204 (1) CHEMBL839927 (1)
CHEMBL838517 (1) CHEMBL1645695 (1)
CHEMBL2341887 (1)
1 / 2
P23280 Carbonic anhydrase 6 Lyase CHEMBL1200739 CHEMBL1645696 (1)
0 / 0
P00915 Carbonic anhydrase 1 Lyase CHEMBL38703 CHEMBL1200739 CHEMBL828816 (1) CHEMBL839657 (1)
CHEMBL838843 (1) CHEMBL1645694 (1)
0 / 0
Q16790 Carbonic anhydrase 9 Lyase CHEMBL38703 CHEMBL839931 (1)
0 / 1
P22748 Carbonic anhydrase 4 Lyase CHEMBL38703 CHEMBL839929 (1) CHEMBL852354 (1)
1 / 1
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase CHEMBL38703 CHEMBL876687 (1) CHEMBL839467 (1)
0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase CHEMBL38703 CHEMBL876687 (1) CHEMBL839467 (1)
0 / 0

CTD interaction (5)

compound gene gene name gene description interaction interaction type form reference
pmid
D006862 875 CBS
HIP4
cystathionine-beta-synthase (EC:4.2.1.22) CBS protein results in increased chemical synthesis of Hydrogen Sulfide increases chemical synthesis
protein 21951228
D006862 875 CBS
HIP4
cystathionine-beta-synthase (EC:4.2.1.22) [CBS protein results in increased chemical synthesis of Hydrogen Sulfide] which results in decreased susceptibility to Methylmercury Compounds decreases response to substance
/ increases chemical synthesis
protein 21951228
D006862 1491 CTH
cystathionase (cystathionine gamma-lyase) (EC:4.4.1.1) [CTH protein co-treated with Cysteine] results in increased chemical synthesis of Hydrogen Sulfide affects cotreatment
/ increases chemical synthesis
protein 18029544
D006862 1491 CTH
cystathionase (cystathionine gamma-lyase) (EC:4.4.1.1) N-acetylpropargylglycine inhibits the reaction [[CTH protein co-treated with Cysteine] results in increased chemical synthesis of Hydrogen Sulfide] affects cotreatment
/ decreases reaction
/ increases chemical synthesis
protein 18029544
D006862 8989 TRPA1
ANKTM1
FEPS
transient receptor potential cation channel, subfamily A, member 1 Hydrogen Sulfide results in increased activity of TRPA1 protein increases activity
protein 18031925

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (2)

OMIM preferred title UniProt
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#600852 Retinitis pigmentosa 17; rp17 P22748

KEGG DISEASE (4)

KEGG disease name UniProt
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H00021 Renal cell carcinoma Q16790 (marker)

Diseases related to CTD interactions

2 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001249 D006862 Asthma marker/mechanism
22357138
D012135 D006862 Respiratory Sounds marker/mechanism
22357138