PCIDB

KNApSAcK Metabolite C00000736

Metabolite

KNApSAcK Entry

id C00000736
Name 1,4-Dihydroxy-2-naphthoic acid
CAS RN 31519-22-9
Standard InChI InChI=1S/C11H8O4/c12-9-5-8(11(14)15)10(13)7-4-2-1-3-6(7)9/h1-5,12-13H,(H,14,15)
Standard InChI (Main Layer) InChI=1S/C11H8O4/c12-9-5-8(11(14)15)10(13)7-4-2-1-3-6(7)9/h1-5,12-13H,(H,14,15)

Cluster

Phytochemical cluster
KCF-S cluster No. 1696

Link

ChEMBL

By standard InChI CHEMBL1232286
By standard InChI Main Layer CHEMBL1232286

KEGG

By LinkDB C03657

CTD

By CAS RN C024023

Species

Summary

Plant class

class name count

Family

family name count
Enterobacteriaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Escherichia coli 562 Enterobacteriaceae Bacteria

Human Protein / Gene in interaction

12 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL1232286 CHEMBL1794524 (1)
0 / 0
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL1232286 CHEMBL1614554 (1) CHEMBL1613776 (1)
CHEMBL1794399 (1)
3 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 CHEMBL1232286 CHEMBL1794471 (1)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL1232286 CHEMBL1794376 (1)
2 / 3
P04150 Glucocorticoid receptor NR3C1 CHEMBL1232286 CHEMBL1794382 (1)
0 / 1
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL1232286 CHEMBL1794293 (1)
5 / 3
Q96RI1 Bile acid receptor NR1H4 CHEMBL1232286 CHEMBL1794437 (1)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL1232286 CHEMBL1794364 (1) CHEMBL1794542 (1)
1 / 1
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL1232286 CHEMBL2114853 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1232286 CHEMBL2114890 (1)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL1232286 CHEMBL1794560 (1)
3 / 4
P35869 Aryl hydrocarbon receptor Transcription Factor CHEMBL1232286 CHEMBL2114849 (1)
0 / 0

CTD interaction (1)

compound gene gene name gene description interaction interaction type form reference
pmid
C024023 2859 GPR35
G protein-coupled receptor 35 1,4-dihydroxy-2-naphthoic acid binds to and results in increased activity of GPR35 protein affects binding
/ increases activity
protein 20826425

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (14)

OMIM preferred title UniProt
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#615363 Estrogen resistance; estrr P03372
#137800 Glioma susceptibility 1; glm1 P37231
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#601665 Obesity P37231
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (13)

KEGG disease name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)