PCIDB

KNApSAcK Metabolite C00007460

Metabolite

KNApSAcK Entry

id C00007460
Name D-myo-Inositol 1,4,5-triphosphate
CAS RN 85166-31-0
Standard InChI InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/t1-,2+,3+,4-,5-,6-/m1/s1
Standard InChI (Main Layer) InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)

Cluster

Phytochemical cluster
KCF-S cluster No. 3922

Link

ChEMBL

By standard InChI CHEMBL279107
By standard InChI Main Layer CHEMBL279107 CHEMBL420806 CHEMBL329137 CHEMBL90310 CHEMBL110078 CHEMBL355920 CHEMBL1160774 CHEMBL1160775 CHEMBL1160776 CHEMBL1160777 CHEMBL1161131 CHEMBL1205794

KEGG

By LinkDB C01245

CTD

By CAS RN D015544

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Brassicaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae

Human Protein / Gene in interaction

4 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q14573 Inositol 1,4,5-trisphosphate receptor type 3 CA CHEMBL279107 CHEMBL873218 (1) CHEMBL701347 (1)
CHEMBL701348 (1) CHEMBL701349 (1)
CHEMBL750779 (1)
0 / 1
Q14642 Type I inositol 1,4,5-trisphosphate 5-phosphatase Enzyme CHEMBL279107 CHEMBL618424 (1)
0 / 0
Q14643 Inositol 1,4,5-trisphosphate receptor type 1 CA CHEMBL279107 CHEMBL873218 (1) CHEMBL701347 (1)
CHEMBL701349 (1) CHEMBL750779 (1)
CHEMBL750780 (1) CHEMBL815029 (1)
CHEMBL815030 (1)
2 / 1
Q14571 Inositol 1,4,5-trisphosphate receptor type 2 CA CHEMBL279107 CHEMBL873218 (1) CHEMBL701347 (1)
CHEMBL701349 (1) CHEMBL750779 (1)
0 / 0

CTD interaction (17)

compound gene gene name gene description interaction interaction type form reference
pmid
D015544 148 ADRA1A
ADRA1C
ADRA1L1
ALPHA1AAR
adrenoceptor alpha 1A ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate increases abundance
protein 9570190
D015544 148 ADRA1A
ADRA1C
ADRA1L1
ALPHA1AAR
adrenoceptor alpha 1A [Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate] affects cotreatment
/ decreases reaction
/ increases abundance
protein 9570190
D015544 148 ADRA1A
ADRA1C
ADRA1L1
ALPHA1AAR
adrenoceptor alpha 1A Quinidine inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate] decreases reaction
/ increases abundance
protein 9570190
D015544 148 ADRA1A
ADRA1C
ADRA1L1
ALPHA1AAR
adrenoceptor alpha 1A Verapamil inhibits the reaction [ADRA1A protein results in increased abundance of Inositol 1,4,5-Trisphosphate] decreases reaction
/ increases abundance
protein 9570190
D015544 147 ADRA1B
ADRA1
ALPHA1BAR
adrenoceptor alpha 1B ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate increases abundance
protein 9570190
D015544 147 ADRA1B
ADRA1
ALPHA1BAR
adrenoceptor alpha 1B [Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate] affects cotreatment
/ decreases reaction
/ increases abundance
protein 9570190
D015544 147 ADRA1B
ADRA1
ALPHA1BAR
adrenoceptor alpha 1B Quinidine inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate] decreases reaction
/ increases abundance
protein 9570190
D015544 147 ADRA1B
ADRA1
ALPHA1BAR
adrenoceptor alpha 1B Verapamil inhibits the reaction [ADRA1B protein results in increased abundance of Inositol 1,4,5-Trisphosphate] decreases reaction
/ increases abundance
protein 9570190
D015544 146 ADRA1D
ADRA1
ADRA1A
ADRA1R
ALPHA1
DAR
dJ779E11.2
adrenoceptor alpha 1D ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate increases abundance
protein 9570190
D015544 146 ADRA1D
ADRA1
ADRA1A
ADRA1R
ALPHA1
DAR
dJ779E11.2
adrenoceptor alpha 1D [Quinidine co-treated with Verapamil] inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate] affects cotreatment
/ decreases reaction
/ increases abundance
protein 9570190
D015544 146 ADRA1D
ADRA1
ADRA1A
ADRA1R
ALPHA1
DAR
dJ779E11.2
adrenoceptor alpha 1D Quinidine inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate] decreases reaction
/ increases abundance
protein 9570190
D015544 146 ADRA1D
ADRA1
ADRA1A
ADRA1R
ALPHA1
DAR
dJ779E11.2
adrenoceptor alpha 1D Verapamil inhibits the reaction [ADRA1D protein results in increased abundance of Inositol 1,4,5-Trisphosphate] decreases reaction
/ increases abundance
protein 9570190
D015544 846 CASR
CAR
EIG8
FHH
FIH
GPRC2A
HHC
HHC1
HYPOC1
NSHPT
PCAR1
calcium-sensing receptor [CASR protein mutant form results in increased susceptibility to Calcium] which results in increased abundance of Inositol 1,4,5-Trisphosphate increases abundance
/ increases response to substance
protein 7874174
D015544 3357 HTR2B
5-HT(2B)
5-HT2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled HTR2B protein mutant form results in decreased abundance of Inositol 1,4,5-Trisphosphate decreases abundance
protein 15625277
D015544 3632 INPP5A
5PTASE
inositol polyphosphate-5-phosphatase, 40kDa (EC:3.1.3.56) benzene 1,2,4-trisphosphate inhibits the reaction [INPP5A protein results in increased metabolism of Inositol 1,4,5-Trisphosphate] decreases reaction
/ increases metabolic processing
protein 18574825
D015544 3632 INPP5A
5PTASE
inositol polyphosphate-5-phosphatase, 40kDa (EC:3.1.3.56) Polyphosphates inhibits the reaction [INPP5A protein results in increased metabolism of Inositol 1,4,5-Trisphosphate] decreases reaction
/ increases metabolic processing
protein 18574825
D015544 7292 TNFSF4
CD134L
CD252
GP34
OX-40L
OX4OL
TXGP1
tumor necrosis factor (ligand) superfamily, member 4 TNFSF4 protein results in increased abundance of Inositol 1,4,5-Trisphosphate increases abundance
protein 19416722

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (2)

OMIM preferred title UniProt
#606658 Spinocerebellar ataxia 15; sca15 Q14643
#117360 Spinocerebellar ataxia 29; sca29 Q14643

KEGG DISEASE (2)

KEGG disease name UniProt
H00408 Type I diabetes mellitus Q14573 (related)
H00063 Spinocerebellar ataxia (SCA) Q14643 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D006332 D015544 Cardiomegaly marker/mechanism
16259952