KNApSAcK Metabolite C00007503
Metabolite
KNApSAcK Entry
| id | C00007503 |
|---|---|
| Name | Pyridoxal phosphate |
| CAS RN | 54-47-7 |
| Standard InChI | InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14) |
| Standard InChI (Main Layer) | InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 3827 |
Link
ChEMBL
| By standard InChI | CHEMBL82202 |
|---|---|
| By standard InChI Main Layer | CHEMBL82202 |
KEGG
| By LinkDB | C00018 |
|---|
CTD
| By CAS RN | D011732 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 1 |
Family
| family name | count |
|---|---|
| Brassicaceae | 1 |
| Enterobacteriaceae | 1 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Arabidopsis thaliana | 3702 | Brassicaceae | rosids | Viridiplantae |
| Escherichia coli | 562 | Enterobacteriaceae | Bacteria |
Human Protein / Gene in interaction
3 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q9UBL9 | P2X purinoceptor 2 | NS | CHEMBL82202 |
CHEMBL751803
(1)
|
0 / 0 |
| P27708 | CAD protein | Enzyme | CHEMBL82202 |
CHEMBL653963
(1)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL82202 |
CHEMBL1738442
(1)
|
0 / 0 |
CTD interaction (6)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D011732 | 2530 |
FUT8
|
fucosyltransferase 8 (alpha (1,6) fucosyltransferase) (EC:2.4.1.68) | Fucose analog inhibits the reaction [Pyridoxal Phosphate results in decreased activity of FUT8 protein] |
decreases activity
/ decreases reaction |
protein |
12770769
|
| D011732 | 2530 |
FUT8
|
fucosyltransferase 8 (alpha (1,6) fucosyltransferase) (EC:2.4.1.68) | Pyridoxal Phosphate results in decreased activity of FUT8 protein |
decreases activity
|
protein |
12770769
|
| D011732 | 2571 |
GAD1
CPSQ1 GAD SCP |
glutamate decarboxylase 1 (brain, 67kDa) (EC:4.1.1.15) | Pyridoxal Phosphate binds to GAD1 protein modified form |
affects binding
|
protein |
15686475
|
| D011732 | 2572 |
GAD2
GAD65 |
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (EC:4.1.1.15) | Pyridoxal Phosphate binds to GAD2 protein |
affects binding
|
protein |
15686475
15690345 15836621 |
| D011732 | 2572 |
GAD2
GAD65 |
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (EC:4.1.1.15) | Pyridoxal Phosphate binds to GAD2 protein modified form |
affects binding
|
protein |
15686475
|
| D011732 | 8566 |
PDXK
C21orf124 C21orf97 PKH PNK |
pyridoxal (pyridoxine, vitamin B6) kinase (EC:2.7.1.35) | PDXK protein results in increased abundance of Pyridoxal Phosphate |
increases abundance
|
protein |
18346762
|
Related Disease
Diseases related to CTD interactions
6 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D000756 | D011732 | Anemia, Sideroblastic |
therapeutic
|
1507421
|
|
| D015179 | D011732 | Colorectal Neoplasms |
therapeutic
|
18708408
|
|
| D004830 | D011732 | Epilepsy, Tonic-Clonic |
marker/mechanism
|
7463050
7633329 |
|
| D007674 | D011732 | Kidney Diseases |
therapeutic
|
2308232
|
|
| D012640 | D011732 | Seizures |
marker/mechanism
|
6469540
7463050 8540225 11587709 |
|
| D026681 | D011732 | Vitamin B 6 Deficiency |
marker/mechanism
|
3341945
|