PCIDB

KCF-S cluster No. 1222 (8 metabolites)

Corresponding Phytochemical cluster No. 11

Plant Species

Cumulative plant class count

class name count
Liliopsida 40
rosids 4
eudicotyledons 2

Cumulative family count

class name count
Asparagaceae 40
Zygophyllaceae 4
Polygonaceae 2

KEGG BRITE br08003 External link 512

Categories (1)

br08003 Category # of metabolite
Spirostan 1

metabolites link (1)

br08003 Category KEGG ID KNApSAcK ID
Spirostan C08902 C00003580

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00003580 External link 512 Hecogenin
CHEMBL1401685
CHEMBL1605286
C007908
8 / 16 / 14 1 / 0
C00032001 External link 512 Manogenin
C00040806 External link 512 25R-Spirost-4-ene-3,12-dione
/ (-)-25R-Spirost-4-ene-3,12-dione
C00042011 External link 512 (5alpha,25R)-Spirostan-3,6,12-trione
C00042083 External link 512 25R-Spirostan-4-ene-3,6,12-trione
C00042576 External link 512 Hecogenone
C00043296 External link 512 Asparacosin A
/ (-)-Asparacosin A
CHEMBL469492
C00043297 External link 512 Asparacosin B
/ (-)-Asparacosin B
CHEMBL473454

Human Protein / Gene in interactions

8 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003580 1 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003580 0 / 0
P02545 Prelamin-A/C Unclassified protein C00003580 11 / 10
P10828 Thyroid hormone receptor beta NR1A2 C00003580 3 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003580 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003580 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003580 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003580 0 / 1

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
54657 UGT1A4, HUG-BR2, UDPGT, UDPGT_1-4, UGT-1D, UGT1-04, UGT1.4, UGT1D UDP glucuronosyltransferase 1 family, polypeptide A4 (EC:2.4.1.17) C00003580

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (16)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (14)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)