KCF-S cluster No. 1223 (8 metabolites)
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| asterids | 5 |
| rosids | 3 |
Cumulative family count
| class name | count |
|---|---|
| Apocynaceae | 4 |
| Meliaceae | 2 |
| Asteraceae | 1 |
| Sclerotiniaceae | 1 |
| Rutaceae | 1 |
KEGG BRITE br08003
Categories (0)
| br08003 Category | # of metabolite |
|---|
metabolites link (0)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
Metabolite list (8)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00025515
|
Kisantamine
|
|
||||
|
C00033550
|
2beta,3beta-Dihydroxy-5alpha-pregn-17(E)-en-16-one
/ (-)-2beta,3beta-Dihydroxy-5alpha-pregn-17(E)-en-16-one |
|
||||
|
C00033551
|
2beta,3beta-Dihydroxy-5alpha-pregn-17(Z)-en-16-one
|
|
||||
|
C00045179
|
3beta-Hydroxy-5alpha-pregn-16-en-20-one
/ (+)-3beta-Hydroxy-5alpha-pregn-16-en-20-one |
C028107
|
|
|||
|
C00047082
|
Pregnenolone
|
CHEMBL77462
CHEMBL383839 CHEMBL253363 CHEMBL1435695 CHEMBL1455777 |
D011284
|
22 / 28 / 19 | 9 / 0 |
|
|
C00049664
|
Pregnenolone
|
CHEMBL77462
CHEMBL383839 CHEMBL253363 CHEMBL1435695 CHEMBL1455777 |
D011284
|
22 / 28 / 19 | 9 / 0 |
|
|
C00049922
|
15alpha-Hydroxyholamine
/ (+)-15alpha-Hydroxyholamine |
CHEMBL464981
|
|
|||
|
C00050121
|
Holamine
|
CHEMBL465586
|
|
Human Protein / Gene in interactions
22 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00047082 C00049664 | 1 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00047082 C00049664 | 3 / 0 |
| O75795 | UDP-glucuronosyltransferase 2B17 | Enzyme | C00047082 C00049664 | 1 / 0 |
| O00204 | Sulfotransferase family cytosolic 2B member 1 | Enzyme | C00047082 C00049664 | 0 / 0 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00047082 C00049664 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00047082 C00049664 | 2 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00047082 C00049664 | 11 / 10 |
| Q16850 | Lanosterol 14-alpha demethylase | Cytochrome P450 51A1 | C00047082 C00049664 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00047082 C00049664 | 0 / 1 |
| P16662 | UDP-glucuronosyltransferase 2B7 | Enzyme | C00047082 C00049664 | 0 / 0 |
| Q06520 | Bile salt sulfotransferase | Enzyme | C00047082 C00049664 | 0 / 0 |
| P04278 | Sex hormone-binding globulin | Secreted protein | C00047082 C00049664 | 0 / 0 |
| P11413 | Glucose-6-phosphate 1-dehydrogenase | Enzyme | C00047082 C00049664 | 1 / 2 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00047082 C00049664 | 7 / 3 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00047082 C00049664 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00047082 C00049664 | 0 / 0 |
| P08185 | Corticosteroid-binding globulin | Secreted protein | C00047082 C00049664 | 1 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00047082 C00049664 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00047082 C00049664 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00047082 C00049664 | 0 / 0 |
| P49888 | Estrogen sulfotransferase | Enzyme | C00047082 C00049664 | 0 / 0 |
| P56937 | 3-keto-steroid reductase | Enzyme | C00047082 C00049664 | 0 / 0 |
9 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1583 | CYP11A1, CYP11A, CYPXIA1, P450SCC | cytochrome P450, family 11, subfamily A, polypeptide 1 (EC:1.14.15.6) |
C00047082
C00049664
|
| 1586 | CYP17A1, CPT7, CYP17, P450C17, S17AH | cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) |
C00047082
C00049664
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00047082
C00049664
|
| 2254 | FGF9, FGF-9, GAF, HBFG-9, HBGF-9, SYNS3 | fibroblast growth factor 9 |
C00047082
C00049664
|
| 2488 | FSHB | follicle stimulating hormone, beta polypeptide |
C00047082
C00049664
|
| 3156 | HMGCR, LDLCQ3 | 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) |
C00047082
C00049664
|
| 3283 | HSD3B1, 3BETAHSD, HSD3B, HSDB3, HSDB3A, I, SDR11E1 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (EC:1.1.1.145 5.3.3.1) |
C00047082
C00049664
|
| 3479 | IGF1, IGF-I, IGF1A, IGFI | insulin-like growth factor 1 (somatomedin C) |
C00047082
C00049664
|
| 8856 | NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR | nuclear receptor subfamily 1, group I, member 2 |
C00047082
C00049664
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (28)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #300908 | Anemia, nonspherocytic hemolytic, due to g6pd deficiency |
P11413
|
| #612560 | Bone mineral density quantitative trait locus 12; bmnd12 |
O75795
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #611489 | Corticosteroid-binding globulin deficiency |
P08185
|
| #218800 | Crigler-najjar syndrome, type i |
P22310
|
| #606785 | Crigler-najjar syndrome, type ii |
P22310
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #143500 | Gilbert syndrome |
P22310
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
KEGG DISEASE (19)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H01163 | Corticosteroid-binding globulin (CBG) deficiency |
P08185
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00101 | Other phagocyte defects |
P11413
(related)
|
| H00668 | Anemia due to disorders of glutathione metabolism |
P11413
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|