KCF-S cluster No. 128 (40 metabolites)

Corresponding Phytochemical cluster No. 72

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (40)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	33
rosids	24
eudicotyledons	8
Liliopsida	3
Euphyllophyta	1
Magnoliophyta	1
Spermatophyta	1

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Cumulative family count (Top 20)

class name	count
Lamiaceae	10
Rosaceae	7
Crassulaceae	5
Rhizophoraceae	4
Bignoniaceae	3
Apocynaceae	3
Verbenaceae	3
Acanthaceae	3
Paeoniaceae	2
Fabaceae	2
Thymelaeaceae	2
Cornaceae	2
Orchidaceae	2
Orobanchaceae	2
Asteraceae	2
Celastraceae	2
Passifloraceae	1
Scrophulariaceae	1
Proteaceae	1
Rubiaceae	1

KEGG BRITE br08003

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Categories (2)

br08003 Category	# of metabolite
Cyanogenic glucosides derived from phenylalanine	3
Cyanogenic glucosides derived from thyrosine	1

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metabolites link (4)

br08003 Category	KEGG ID	KNApSAcK ID
Cyanogenic glucosides derived from phenylalanine	C08325	C00001437
Cyanogenic glucosides derived from phenylalanine	C08335	C00001449
Cyanogenic glucosides derived from thyrosine	C08339	C00001453
Cyanogenic glucosides derived from phenylalanine	C01870	C00001458

Metabolite list (40)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001437	Amygdalin / (R)-Amygdalin	CHEMBL515712 CHEMBL461727 CHEMBL1967951 CHEMBL2007233	D000678	92 / 37 / 31
C00001449	Lucumin
C00001453	Proteacin
C00001458	Vicianin
C00002705	Paeonolide	CHEMBL1080061
C00002755	Lusitanicoside
C00024141	Bungeiside C		C080185
C00024142	Bungeiside D		C080186
C00024143	Syringin-4-O-beta-glucoside
C00026884	Cappariloside B
C00026980	Calanthoside / Glucoindican / Calanthoside A
C00029469	2-Phenylethyl O-beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside
C00029976	Cistanoside E
C00030098	Verbasoside / (-)-Verbasoside / Decaffeoylverbascoside / (-)-Decaffeoylverbascoside	CHEMBL1779146
C00030286	Foliachinenoside B1 / (-)-Foliachinenoside B1
C00030287	Foliachinenoside B2 / (-)-Foliachinenoside B2
C00030363	Gein / Geoside
C00030989	Phenylethyl O-alpha-L-arabinopyranosyl-(1->6)-beta-D-glucopyranoside
C00031166	Rhyncoside A
C00031167	Rhyncoside B / (-)-Rhyncoside B
C00031168	Rhyncoside C / (-)-Rhyncoside C
C00031169	Rhyncoside D / (-)-Rhyncoside D
C00031184	Rosarin
C00031185	Rosavin	CHEMBL1083511		1 / 1 / 1
C00031195	Rossicasin A / (-)-Rossicasin A
C00031196	Rossicasin B / (-)-Rossicasin B
C00031776	Erythroxyloside B / (-)-Erythroxyloside B
C00032551	Zizybeoside I
C00032760	(-)-Benzyl beta-primeveroside / Benzyl alcohol beta-D-xylopyranosyl (1->6)-beta-D-glucopyranoside	CHEMBL1371061	C069904	3 / 1 / 1
C00033402	Syringinoside / (-)-Syringinoside
C00035591	Diospyrososide
C00036505	2-Phenylethyl O-??-L-arabinopyranosyl-(1->6)-??-glucopyranoside / 2-Phenylethyl O-alpha-arabinopyranosyl-(1->6)-beta-glucopyranoside
C00037004	Darendoside B	CHEMBL462940	C080861
C00037325	Isoconiferinoside
C00039468	Itoside I / (-)-Itoside I
C00039839	Neolloydosin
C00040926	Coniferinoside
C00042516	Forsythoside E
C00044318	Sparanoside B / (-)-Sparanoside B
C00049666	Sibiricaphenone / (-)-Sibiricaphenone

Human Protein / Gene in interactions

96 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001437	1 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00001437	0 / 0
P27338	Amine oxidase [flavin-containing] B	Oxidoreductase	C00001437	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00001437	0 / 3
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00001437	2 / 2
P08246	Neutrophil elastase	S1A	C00001437	2 / 1
P33765	Adenosine receptor A3	Adenosine receptor	C00001437	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00001437	0 / 0
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00001437	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00032760	1 / 1
P29466	Caspase-1	C14	C00001437	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00001437	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00001437	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00001437	2 / 2
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00031185	1 / 1
P00918	Carbonic anhydrase 2	Lyase	C00001437	1 / 2
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00001437	0 / 1
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00001437	1 / 1
P25021	Histamine H2 receptor	Histamine receptor	C00001437	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00001437	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00001437	1 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00001437	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00001437	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00001437	0 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00001437	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00001437	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00001437	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001437	0 / 1
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00001437	1 / 8
P14416	D(2) dopamine receptor	Dopamine receptor	C00001437	2 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00001437	0 / 0
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00001437	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00001437	0 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00001437	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00001437	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00001437	0 / 0
P01730	T-cell surface glycoprotein CD4	Surface antigen	C00001437	1 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00001437	1 / 1
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00001437	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00001437	1 / 0
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00001437	0 / 0
O75496	Geminin	Unclassified protein	C00032760	0 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00001437	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00001437	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00001437	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00001437	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00001437	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00001437	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00001437	0 / 1
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00001437	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00001437	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00001437	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00001437	1 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00001437	0 / 0
P08311	Cathepsin G	S1A	C00001437	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00001437	1 / 0
P03956	Interstitial collagenase	M10A	C00001437	0 / 1
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00001437	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00001437	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00001437	0 / 1
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00001437	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00001437	0 / 0
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00001437	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00001437	2 / 0
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00001437	5 / 9
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00001437	1 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00001437	0 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00001437	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00001437	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00001437	0 / 0
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00001437	1 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00001437	0 / 0
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00001437	2 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001437	0 / 0
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00001437	0 / 0
P03372	Estrogen receptor	NR3A1	C00001437	1 / 1
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00001437	1 / 0
P22303	Acetylcholinesterase	Hydrolase	C00001437	1 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00001437	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00001437	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00001437	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00001437	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00001437	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00001437	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00001437	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001437	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001437	0 / 1
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00001437	0 / 0
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00001437	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00001437	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00001437	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00001437	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00001437	1 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00001437	0 / 1
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00001437	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00032760	0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions