| class name | count |
|---|---|
| eudicotyledons | 103 |
| class name | count |
|---|---|
| Ranunculaceae | 103 |
| br08003 Category | # of metabolite |
|---|---|
| Terpenoid alkaloids | 9 |
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00001610
|
Aconifine
|
CHEMBL2062833
|
|
|||
|
C00001611
|
Aconitine
|
CHEMBL1320549
CHEMBL1434120 CHEMBL1597605 CHEMBL1719550 CHEMBL1979562 CHEMBL2103747 |
D000157
|
91 / 49 / 41 | 9 / 6 |
|
|
C00001619
|
Beiwutine
|
|
||||
|
C00001620
|
Bikhaconitine
|
|
||||
|
C00001633
|
Delphinine
|
CHEMBL1995442
|
|
|||
|
C00001639
|
Falaconitine
|
CHEMBL1991005
|
|
|||
|
C00001644
|
Hypaconitine
|
CHEMBL400315
CHEMBL2062951 |
C058309
|
7 / 0 |
|
|
|
C00001647
|
Indaconitine
|
|
||||
|
C00001648
|
Jesaconitine
|
C069418
|
|
|||
|
C00001654
|
Mesaconitine
|
CHEMBL400315
CHEMBL2062951 |
C019470
|
|
||
|
C00001660
|
Pseudaconitine
|
CHEMBL509646
|
|
|||
|
C00027683
|
14-Benzoylaconine
|
CHEMBL2062825
|
C047307
|
|
||
|
C00027689
|
14-O-benzoylperegrine
|
|
||||
|
C00027706
|
1-Epicrassicaudine
|
|
||||
|
C00027743
|
3-Deoxyaconitine
|
CHEMBL400316
CHEMBL2062827 |
C057219
|
|
||
|
C00028037
|
Chasmaconitine
|
|
||||
|
C00028166
|
Deoxyaconitine
/ 3-Deoxyaconitine |
CHEMBL400316
CHEMBL2062827 |
C057219
|
|
||
|
C00028276
|
Foresaconitine
/ Vilmorrianine C |
|
||||
|
C00028427
|
Karaconitine
|
|
||||
|
C00028494
|
Ludaconitine
|
|
||||
|
C00028576
|
Mesaconitine
|
CHEMBL1877791
|
C019470
|
1 / 0 / 0 |
|
|
|
C00029255
|
Yunaconitine
|
C069835
|
|
|||
|
C00029407
|
16-epi-Pyromesaconitine
|
|
||||
|
C00030727
|
Manshuritine
|
CHEMBL2062824
|
|
|||
|
C00031504
|
14-O-Cinnamoylneoline
|
|
||||
|
C00031692
|
Crassicauline A
|
|
||||
|
C00038407
|
Aljesaconitine A
|
CHEMBL249661
|
|
|||
|
C00038990
|
Deoxyjesaconitine
|
CHEMBL247593
|
|
|||
|
C00039377
|
Hokbusine A
|
CHEMBL439232
|
|
|||
|
C00041040
|
Liaconitine A
/ (+)-Liaconitine A |
|
||||
|
C00041041
|
Liaconitine B
/ (-)-Liaconitine B |
|
||||
|
C00041042
|
Liaconitine C
/ (+)-Liaconitine C |
|
||||
|
C00044867
|
Leueantine A
/ (+)-Leueantine A |
|
||||
|
C00044868
|
Leueantine B
/ (+)-Leueantine B |
|
||||
|
C00044869
|
Leueantine C
/ (+)-Leueantine C |
|
||||
|
C00044870
|
Leueantine D
/ (+)-Leueantine D |
|
||||
|
C00046582
|
3'-Methoxyacoforestinine
|
CHEMBL501580
|
|
|||
|
C00046740
|
Faleoconitine
|
CHEMBL510978
|
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001611 | 1 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00001611 | 2 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00001611 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00001611 | 0 / 3 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00001611 | 2 / 2 |
| P08246 | Neutrophil elastase | S1A | C00001611 | 2 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00001611 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00001611 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00001611 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00001611 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00001611 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00001611 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00001611 | 2 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001611 | 11 / 10 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00001611 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00001611 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00001611 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00001611 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00001611 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00001611 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00001611 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00001611 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00001611 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00001611 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00001611 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00001611 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001611 | 0 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00001611 | 1 / 8 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00001611 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00001611 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00001611 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00001611 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00001611 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00001611 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00001611 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00001611 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00001611 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00001611 | 1 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00001611 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00001611 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00001611 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00001611 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00001611 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00001611 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00001611 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00001611 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00001611 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00001611 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00001611 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00001611 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00001611 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00001611 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00001611 | 1 / 0 |
| P03956 | Interstitial collagenase | M10A | C00001611 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00001611 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00001611 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00001611 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00001611 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00001611 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00001611 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00001611 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00001611 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00001611 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00001611 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00001611 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00001611 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00001611 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00001611 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00001611 | 2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001611 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00001611 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00001611 | 1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00001611 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00001611 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00001611 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00001611 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00001611 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00001611 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00001611 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00001611 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00001611 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001611 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001611 | 0 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00001611 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00028576 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00001611 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00001611 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00001611 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00001611 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00001611 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00001611 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00001611 | 0 / 0 |
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00001611
C00001644
|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00001611
C00001644
|
| 1558 | CYP2C8, CPC8, CYPIIC8, MP-12/MP-20 | cytochrome P450, family 2, subfamily C, polypeptide 8 (EC:1.14.14.1) |
C00001611
C00001644
|
| 1565 | CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 | cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) |
C00001611
C00001644
|
| 1577 | CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 | cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) |
C00001611
C00001644
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00001611
C00001644
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00001644
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00001611
|
| 5894 | RAF1, CRAF, NS5, Raf-1, c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) |
C00001611
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00001611
|
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
| KEGG | name | UniProt |
|---|---|---|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001145 | Arrhythmias, Cardiac |
C00001611
|
| D001281 | Atrial Fibrillation |
C00001611
|
| D001282 | Atrial Flutter |
C00001611
|
| D009361 | Neoplasm Invasiveness |
C00001611
|
| D016171 | Torsades de Pointes |
C00001611
|
| D014693 | Ventricular Fibrillation |
C00001611
|