PCIDB

KCF-S cluster No. 1556 (7 metabolites)

Plant Species

Cumulative plant class count

class name count

Cumulative family count

class name count
Aspergillaceae 4
Elaphomycetaceae 3
Nocardiaceae 1

KEGG BRITE br08003 External link 512

Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (7)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00000547 External link 512 Lovastatin
/ Monacolin K
/ (+)-Mevinolin
CHEMBL503
CHEMBL79583
CHEMBL333443
CHEMBL140273
CHEMBL167159
CHEMBL1230589
CHEMBL1394089
CHEMBL1515625
D008148
125 / 74 / 58 75 / 61
C00000564 External link 512 Mevastatin
/ Antibiotic ML 236B
/ Compactin(Penicillium)
CHEMBL300596
CHEMBL54440
CHEMBL1330357
CHEMBL1355448
CHEMBL1526351
CHEMBL1710493
CHEMBL2115055
CHEMBL2115058
CHEMBL2115471
CHEMBL2115472
115 / 82 / 83
C00017080 External link 512 L 669262
C068819
C00017831 External link 512 Monacolin M
C051483
C00018332 External link 512 Dihydromevinolin
CHEMBL54712
CHEMBL76114
C031351
C00018337 External link 512 Dihydrocompactin
/ (+)-Dihydrocompactin
/ 4a,5-Dihydrocompactin
C031380
C00018631 External link 512 Monacolin X
C045374

Human Protein / Gene in interactions

140 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000547 C00000564 1 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00000547 C00000564 1 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000547 C00000564 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000547 C00000564 4 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00000547 C00000564 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00000547 C00000564 0 / 1
P21728 D(1A) dopamine receptor Dopamine receptor C00000547 C00000564 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000547 C00000564 0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000547 C00000564 2 / 2
P08246 Neutrophil elastase S1A C00000547 C00000564 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00000547 C00000564 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00000547 C00000564 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00000547 C00000564 0 / 0
P29466 Caspase-1 C14 C00000547 C00000564 0 / 0
P17252 Protein kinase C alpha type Alpha C00000547 C00000564 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00000547 C00000564 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00000547 C00000564 1 / 1
P14780 Matrix metalloproteinase-9 M10A C00000547 C00000564 2 / 2
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00000547 C00000564 0 / 0
P02545 Prelamin-A/C Unclassified protein C00000547 C00000564 11 / 10
P16473 Thyrotropin receptor Glycohormone receptor C00000547 C00000564 3 / 2
P30542 Adenosine receptor A1 Adenosine receptor C00000547 C00000564 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000547 C00000564 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000547 C00000564 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000547 C00000564 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00000547 C00000564 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00000547 C00000564 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00000547 C00000564 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00000547 C00000564 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00000547 C00000564 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000547 C00000564 0 / 0
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00000547 C00000564 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00000547 C00000564 1 / 1
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00000547 C00000564 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00000547 C00000564 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00000547 C00000564 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000547 C00000564 0 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000547 C00000564 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000547 C00000564 1 / 8
P11473 Vitamin D3 receptor NR1I1 C00000547 C00000564 2 / 3
P14416 D(2) dopamine receptor Dopamine receptor C00000547 C00000564 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000547 C00000564 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00000547 C00000564 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000547 C00000564 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00000547 C00000564 0 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00000547 C00000564 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00000547 C00000564 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00000547 C00000564 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00000547 C00000564 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00000547 C00000564 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00000547 C00000564 1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000547 C00000564 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000547 C00000564 1 / 1
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000547 C00000564 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00000547 C00000564 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00000547 C00000564 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00000547 C00000564 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00000547 C00000564 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000547 C00000564 2 / 0
O75496 Geminin Unclassified protein C00000547 C00000564 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00000547 C00000564 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00000547 C00000564 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00000547 C00000564 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00000547 C00000564 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00000547 C00000564 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00000547 C00000564 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000547 C00000564 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000547 C00000564 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00000547 C00000564 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00000547 C00000564 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00000547 C00000564 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00000547 C00000564 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00000547 C00000564 0 / 0
P08311 Cathepsin G S1A C00000547 C00000564 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00000547 C00000564 1 / 0
P03956 Interstitial collagenase M10A C00000547 C00000564 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00000547 C00000564 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000547 C00000564 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00000547 C00000564 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00000547 C00000564 0 / 0
P22303 Acetylcholinesterase Hydrolase C00000547 C00000564 1 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000547 C00000564 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00000547 C00000564 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00000547 C00000564 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00000547 C00000564 0 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000547 C00000564 1 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00000547 C00000564 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00000547 C00000564 2 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000547 C00000564 0 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00000547 C00000564 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00000547 C00000564 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00000547 C00000564 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000547 C00000564 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00000547 C00000564 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00000547 C00000564 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00000547 C00000564 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00000547 C00000564 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000547 C00000564 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00000547 C00000564 2 / 1
P03372 Estrogen receptor NR3A1 C00000547 C00000564 1 / 1
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00000547 1 / 1
Q01453 Peripheral myelin protein 22 Unclassified protein C00000564 5 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00000547 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000564 0 / 0
Q8NER1 Transient receptor potential cation channel subfamily V member 1 TRPV (Vanilloid) C00000564 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00000547 5 / 3
P14324 Farnesyl pyrophosphate synthase Transferase C00000547 0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00000547 1 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00000564 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00000564 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00000564 7 / 3
P46721 Solute carrier organic anion transporter family member 1A2 Unclassified protein C00000547 0 / 0
P17301 Integrin alpha-2 Unclassified protein C00000547 0 / 0
P42858 Huntingtin Unclassified protein C00000564 1 / 1
Q92830 Histone acetyltransferase KAT2A Enzyme C00000547 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00000564 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00000547 0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt C00000547 4 / 1
Q92769 Histone deacetylase 2 Hydrolase C00000547 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000564 0 / 0
P20701 Integrin alpha-L Membrane receptor C00000547 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00000564 1 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000547 4 / 3
P54132 Bloom syndrome protein Enzyme C00000564 1 / 2
P08183 Multidrug resistance protein 1 drug C00000547 1 / 0
Q16850 Lanosterol 14-alpha demethylase Cytochrome P450 51A1 C00000547 0 / 0
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00000547 0 / 0
Q13547 Histone deacetylase 1 Hydrolase C00000547 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00000547 0 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00000547 0 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00000547 1 / 0
P05362 Intercellular adhesion molecule 1 Adhesion C00000547 1 / 2
Q9UBN7 Histone deacetylase 6 Hydrolase C00000547 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000547 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00000564 7 / 37
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000547 1 / 1
P42345 Serine/threonine-protein kinase mTOR Enzyme C00000564 0 / 0
O00255 Menin Unclassified protein C00000564 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000564 1 / 2
P05107 Integrin beta-2 Membrane receptor C00000547 1 / 1

75 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
19 ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD ATP-binding cassette, sub-family A (ABC1), member 1 C00000547
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00000547
1244 ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP ATP-binding cassette, sub-family C (CFTR/MRP), member 2 C00000547
59 ACTA2, AAT6, ACTSA, MYMY5 actin, alpha 2, smooth muscle, aorta C00000547
9465 AKAP7, AKAP15, AKAP18 A kinase (PRKA) anchor protein 7 C00000547
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00000547
287 ANK2, ANK-2, LQT4, brank-2 ankyrin 2, neuronal C00000547
335 APOA1 apolipoprotein A-I C00000547
338 APOB, FLDB, LDLCQ4 apolipoprotein B C00000547
581 BAX, BCL2L4 BCL2-associated X protein C00000547
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000547
10018 BCL2L11, BAM, BIM, BOD BCL2-like 11 (apoptosis facilitator) C00000547
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00000547
835 CASP2, CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57 caspase 2, apoptosis-related cysteine peptidase (EC:3.4.22.55) C00000547
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000547
839 CASP6, MCH2 caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59) C00000547
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00000547
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00000547
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00000547
896 CCND3 cyclin D3 C00000547
960 CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 CD44 molecule (Indian blood group) C00000547
998 CDC42, CDC42Hs, G25K cell division cycle 42 C00000547
1017 CDK2, p33(CDK2) cyclin-dependent kinase 2 (EC:2.7.11.22) C00000547
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00000547
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00000547
1063 CENPF, CENF, PRO1779, hcp-1 centromere protein F, 350/400kDa C00000547
1111 CHEK1, CHK1 checkpoint kinase 1 (EC:2.7.11.1) C00000547
1499 CTNNB1, CTNNB, MRD19, armadillo catenin (cadherin-associated protein), beta 1, 88kDa C00000547
1558 CYP2C8, CPC8, CYPIIC8, MP-12/MP-20 cytochrome P450, family 2, subfamily C, polypeptide 8 (EC:1.14.14.1) C00000547
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00000547
55840 EAF2, BM040, TRAITS, U19 ELL associated factor 2 C00000547
1950 EGF, HOMG4, URG epidermal growth factor C00000547
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00000547
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00000547
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00000547
2194 FASN, FAS, OA-519, SDR27X1 fatty acid synthase (EC:2.3.1.85 2.3.1.38 2.3.1.39 2.3.1.41 3.1.2.14 4.2.1.59 1.1.1.100 1.3.1.39) C00000547
2222 FDFT1, DGPT, ERG9, SQS, SS farnesyl-diphosphate farnesyltransferase 1 (EC:2.5.1.21) C00000547
2596 GAP43, B-50, PP46 growth associated protein 43 C00000547
2932 GSK3B glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) C00000547
3014 H2AFX, H2A.X, H2A/X, H2AX H2A histone family, member X C00000547
3156 HMGCR, LDLCQ3 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) C00000547
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00000547
3265 HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1 Harvey rat sarcoma viral oncogene homolog C00000547
3638 INSIG1, CL-6, CL6 insulin induced gene 1 C00000547
3845 KRAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RASK2 Kirsten rat sarcoma viral oncogene homolog C00000547
3949 LDLR, FH, FHC, LDLCQ2 low density lipoprotein receptor C00000547
51176 LEF1, LEF-1, TCF10, TCF1ALPHA, TCF7L3 lymphoid enhancer-binding factor 1 C00000547
4001 LMNB1, ADLD, LMN, LMN2, LMNB lamin B1 C00000547
4018 LPA, AK38, APOA, LP lipoprotein, Lp(a) (EC:3.4.21.-) C00000547
9663 LPIN2 lipin 2 (EC:3.1.3.4) C00000547
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00000547
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00000547
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00000547
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00000547
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00000547
4893 NRAS, ALPS4, N-ras, NRAS1, NS6 neuroblastoma RAS viral (v-ras) oncogene homolog C00000547
29780 PARVB, CGI-56 parvin, beta C00000547
5446 PON3 paraoxonase 3 (EC:3.1.1.2 3.1.8.1 3.1.1.81) C00000547
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00000547
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00000547
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00000547
5879 RAC1, Rac-1, TC-25, p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) C00000547
5894 RAF1, CRAF, NS5, Raf-1, c-Raf v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) C00000547
5906 RAP1A, KREV-1, KREV1, RAP1, SMGP21 RAP1A, member of RAS oncogene family C00000547
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00000547
387 RHOA, ARH12, ARHA, RHO12, RHOH12 ras homolog family member A C00000547
388 RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6 ras homolog family member B C00000547
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00000547
6721 SREBF2, SREBP-2, SREBP2, bHLHd2 sterol regulatory element binding transcription factor 2 C00000547
261729 STEAP2, IPCA1, PCANAP1, PUMPCn, STAMP1, STMP STEAP family member 2, metalloreductase C00000547
7038 TG, AITD3, TGN thyroglobulin C00000547
7040 TGFB1, CED, DPD1, LAP, TGFB, TGFbeta transforming growth factor, beta 1 C00000547
7054 TH, DYT14, DYT5b, TYH tyrosine hydroxylase (EC:1.14.16.2) C00000547
8743 TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL tumor necrosis factor (ligand) superfamily, member 10 C00000547
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000547

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (98)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#210900 Bloom syndrome; blm P54132
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#114480 Breast cancer P31749
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P31749
P84022
#615109 Cowden syndrome 6; cws6 P31749
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
P37231
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#116920 Leukocyte adhesion deficiency, type i; lad P05107
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#611162 Malaria, susceptibility to P05362
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#176920 Proteus syndrome P31749
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (93)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00099 Leukocyte adhesion deficiency (LAD) P05107 (related)
H00083 Allograft rejection P05362 (related)
H00080 Systemic lupus erythematosus P05362 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

61 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D058186 Acute Kidney Injury C00000547
D000743 Anemia, Hemolytic C00000547
D000799 Angioedema C00000547
D000855 Anorexia C00000547
D018771 Arthralgia C00000547
D001930 Brain Injuries C00000547
D002493 Central Nervous System Diseases C00000547
D002779 Cholestasis C00000547
D002780 Cholestasis, Intrahepatic C00000547
D003110 Colonic Neoplasms C00000547
D003324 Coronary Artery Disease C00000547
D003866 Depressive Disorder C00000547
D003882 Dermatomyositis C00000547
D056486 Drug-Induced Liver Injury C00000547
D064420 Drug-Related Side Effects and Adverse Reactions C00000547
D004401 Dysarthria C00000547
D050171 Dyslipidemias C00000547
D001068 Eating Disorders C00000547
D005076 Exanthema C00000547
D005483 Flushing C00000547
D005767 Gastrointestinal Diseases C00000547
D006261 Headache C00000547
D006330 Heart Defects, Congenital C00000547
D006937 Hypercholesterolemia C00000547
D006949 Hyperlipidemias C00000547
D006938 Hyperlipoproteinemia Type II C00000547
D006973 Hypertension C00000547
D015228 Hypertriglyceridemia C00000547
D006987 Hypesthesia C00000547
D052456 Hypoalphalipoproteinemias C00000547
D007565 Jaundice C00000547
D041781 Jaundice, Obstructive C00000547
D007676 Kidney Failure, Chronic C00000547
D008103 Liver Cirrhosis C00000547
D008223 Lymphoma C00000547
D008325 Mammary Neoplasms, Experimental C00000547
D017240 Mitochondrial Myopathies C00000547
D019964 Mood Disorders C00000547
D009069 Movement Disorders C00000547
D009120 Muscle Cramp C00000547
D018908 Muscle Weakness C00000547
D009135 Muscular Diseases C00000547
D009212 Myoglobinuria C00000547
D009220 Myositis C00000547
D009336 Necrosis C00000547
D000857 Olfaction Disorders C00000547
D009846 Oliguria C00000547
D010146 Pain C00000547
D010190 Pancreatic Neoplasms C00000547
D010292 Paresthesia C00000547
D010523 Peripheral Nervous System Diseases C00000547
D011115 Polyneuropathies C00000547
D011507 Proteinuria C00000547
D051437 Renal Insufficiency C00000547
D012206 Rhabdomyolysis C00000547
D012509 Sarcoma C00000547
D012817 Signs and Symptoms, Digestive C00000547
D012893 Sleep Disorders C00000547
D007319 Sleep Initiation and Maintenance Disorders C00000547
D013733 Testicular Diseases C00000547
D014581 Urticaria C00000547