KCF-S cluster No. 162 (35 metabolites)
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 38 |
Cumulative family count
| class name | count |
|---|---|
| Clusiaceae | 38 |
KEGG BRITE br08003
Categories (0)
| br08003 Category | # of metabolite |
|---|
metabolites link (0)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
Metabolite list (35)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00002950
|
Gambogic acid
|
CHEMBL265955
CHEMBL555017 CHEMBL1477081 |
C052659
|
30 / 28 / 58 | 12 / 1 |
|
|
C00002967
|
Morellin
|
|
||||
|
C00030118
|
Deoxygaudichaudione A
|
|
||||
|
C00030120
|
Desoxygambogenin
/ (-)-Desoxygambogenin |
|
||||
|
C00030121
|
Desoxymorellin
|
CHEMBL194671
|
|
|||
|
C00030342
|
Gambogenic acid
|
CHEMBL2205166
|
2 / 0 / 0 |
|
||
|
C00030343
|
Gambogoic acid A
|
|
||||
|
C00030344
|
Gambogoic acid B
|
|
||||
|
C00030362
|
Gaudichaudic acid
|
|
||||
|
C00030528
|
Isogambogenic acid
|
CHEMBL2205166
|
2 / 0 / 0 |
|
||
|
C00030529
|
Isogambogic acid
|
CHEMBL265955
CHEMBL555017 CHEMBL1477081 |
30 / 28 / 58 |
|
||
|
C00030538
|
Isomorellic acid
|
CHEMBL1765391
|
|
|||
|
C00030539
|
Isomorellinol
|
|
||||
|
C00030793
|
Morellic acid
|
CHEMBL1765391
|
|
|||
|
C00031845
|
Hanburinone
/ (-)-Hanburinone |
|
||||
|
C00031908
|
Isomoreollin B
|
|
||||
|
C00032031
|
Moreollic acid
|
|
||||
|
C00045065
|
Scortechinone J
/ (-)-Scortechinone J |
|
||||
|
C00047147
|
3-O-Geranylforbesione
/ (-)-3-O-Geranylforbesione |
|
||||
|
C00047154
|
7-Methoxygambogellic acid
/ (-)-7-Methoxygambogellic acid |
CHEMBL539963
|
|
|||
|
C00047155
|
7-Methoxyisomorellinol
/ (-)-7-Methoxyisomorellinol |
CHEMBL541450
|
|
|||
|
C00047157
|
8,8a-Dihydro-8-hydroxygambogenic acid
/ (-)-8,8a-Dihydro-8-hydroxygambogenic acid |
CHEMBL563615
|
|
|||
|
C00047158
|
8,8a-Dihydro-8-hydroxymorellic acid
/ (-)-8,8a-Dihydro-8-hydroxymorellic acid |
CHEMBL553112
|
|
|||
|
C00047221
|
Epigambogic acid
/ (-)-Epigambogic acid |
CHEMBL265955
CHEMBL555017 CHEMBL1477081 |
30 / 28 / 58 |
|
||
|
C00047222
|
Epiisogambogic acid
|
CHEMBL265955
CHEMBL555017 CHEMBL1477081 |
30 / 28 / 58 |
|
||
|
C00047234
|
Gambogefic acid
/ (-)-Gambogefic acid |
CHEMBL554811
|
|
|||
|
C00047235
|
Gambogellic acid
|
CHEMBL1241412
|
|
|||
|
C00047236
|
Gambogenific acid
/ (-)-Gambogenific acid |
CHEMBL558353
|
|
|||
|
C00047237
|
Gambogin
|
CHEMBL371431
|
|
|||
|
C00047238
|
Gambospiroene
/ (+)-Gambospiroene |
|
||||
|
C00047243
|
Hanburin
|
|
||||
|
C00047248
|
Isogambogenin
|
|
||||
|
C00047249
|
Isomorellin
|
|
||||
|
C00047308
|
Methyl 8,8a-dihydromorellate
/ (-)-Methyl 8,8a-dihydromorellate |
CHEMBL552883
|
|
|||
|
C00047328
|
Oxygambogic acid
/ (-)-Oxygambogic acid |
|
Human Protein / Gene in interactions
30 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q99757 | Thioredoxin, mitochondrial | Unclassified protein | C00002950 C00030342 C00030528 C00030529 C00047221 C00047222 | 0 / 0 |
| P10599 | Thioredoxin | Unclassified protein | C00002950 C00030342 C00030528 C00030529 C00047221 C00047222 | 0 / 0 |
| Q16548 | Bcl-2-related protein A1 | Unclassified protein | C00002950 C00030529 C00047221 C00047222 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002950 C00030529 C00047221 C00047222 | 4 / 1 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00002950 C00030529 C00047221 C00047222 | 0 / 0 |
| P04629 | High affinity nerve growth factor receptor | Trk | C00002950 C00030529 C00047221 C00047222 | 2 / 3 |
| Q16543 | Hsp90 co-chaperone Cdc37 | Unclassified protein | C00002950 C00030529 C00047221 C00047222 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00002950 C00030529 C00047221 C00047222 | 1 / 2 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00002950 C00030529 C00047221 C00047222 | 2 / 3 |
| O14920 | Inhibitor of nuclear factor kappa-B kinase subunit beta | Other serine/threonine protein kinase | C00002950 C00030529 C00047221 C00047222 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00002950 C00030529 C00047221 C00047222 | 0 / 0 |
| Q16620 | BDNF/NT-3 growth factors receptor | Trk | C00002950 C00030529 C00047221 C00047222 | 1 / 1 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002950 C00030529 C00047221 C00047222 | 0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00002950 C00030529 C00047221 C00047222 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002950 C00030529 C00047221 C00047222 | 0 / 0 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00002950 C00030529 C00047221 C00047222 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002950 C00030529 C00047221 C00047222 | 0 / 0 |
| Q00987 | E3 ubiquitin-protein ligase Mdm2 | Other nuclear protein | C00002950 C00030529 C00047221 C00047222 | 1 / 5 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002950 C00030529 C00047221 C00047222 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002950 C00030529 C00047221 C00047222 | 2 / 2 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002950 C00030529 C00047221 C00047222 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002950 C00030529 C00047221 C00047222 | 0 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002950 C00030529 C00047221 C00047222 | 4 / 3 |
| Q07817 | Bcl-2-like protein 1 | Other cytosolic protein | C00002950 C00030529 C00047221 C00047222 | 0 / 0 |
| P10415 | Apoptosis regulator Bcl-2 | Other cytosolic protein | C00002950 C00030529 C00047221 C00047222 | 0 / 7 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002950 C00030529 C00047221 C00047222 | 0 / 0 |
| Q16288 | NT-3 growth factor receptor | Trk | C00002950 C00030529 C00047221 C00047222 | 0 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002950 C00030529 C00047221 C00047222 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002950 C00030529 C00047221 C00047222 | 7 / 37 |
| P25963 | NF-kappa-B inhibitor alpha | Other cytosolic protein | C00002950 C00030529 C00047221 C00047222 | 1 / 2 |
12 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 9131 | AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 | apoptosis-inducing factor, mitochondrion-associated, 1 |
C00002950
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00002950
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00002950
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00002950
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00002950
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00002950
|
| 2932 | GSK3B | glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) |
C00002950
|
| 8202 | NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP | nuclear receptor coactivator 3 (EC:2.3.1.48) |
C00002950
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00002950
|
| 6198 | RPS6KB1, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70_S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha | ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1) |
C00002950
|
| 7298 | TYMS, HST422, TMS, TS | thymidylate synthetase (EC:2.1.1.45) |
C00002950
|
| 7372 | UMPS, OPRT | uridine monophosphate synthetase (EC:2.4.2.10 4.1.1.23) |
C00002950
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (28)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #614401 | Accelerated tumor formation, susceptibility to; actfs |
Q00987
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #612132 | Ectodermal dysplasia, anhidrotic, with t-cell immunodeficiency, autosomal dominant |
P25963
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #256800 | Insensitivity to pain, congenital, with anhidrosis; cipa |
P04629
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #211980 | Lung cancer |
P04637
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #613886 | Obesity, hyperphagia, and developmental delay |
Q16620
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188550 | Thyroid carcinoma, papillary |
P04629
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (58)
| KEGG | name | UniProt |
|---|---|---|
| H00032 | Thyroid cancer |
P04629
(related)
P04637 (related) |
| H00043 | Neuroblastoma |
P04629
(related)
P04629 (marker) Q16288 (related) Q16620 (related) |
| H00265 | Hereditary sensory and autonomic neuropathy (HSAN) |
P04629
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
P10415 (related) |
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
P10415 (related) |
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
P10415 (related) |
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) Q00987 (related) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
P10415 (related) Q00987 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) Q00987 (related) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
P10415 (related) |
| H00042 | Glioma |
P04637
(related)
P04637 (marker) Q00987 (related) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00030 | Cervical cancer |
P10415
(related)
|
| H00054 | Nasopharyngeal cancer |
P10415
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00007 | Hodgkin lymphoma |
P25963
(related)
|
| H00095 | Ectodermal dysplasia associated immunodeficiency (EDA-ID) |
P25963
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00037 | Alveolar rhabdomyosarcoma |
Q00987
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|