KCF-S cluster No. 166 (35 metabolites)
Corresponding Phytochemical cluster No. 10
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| eudicotyledons | 75 |
| asterids | 1 |
Cumulative family count
| class name | count |
|---|---|
| Ranunculaceae | 75 |
| Asteraceae | 1 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Terpenoid alkaloids | 12 |
metabolites link (13)
Metabolite list (35)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00001613
|
Anhwiedelphinine
|
CHEMBL508121
|
|
|||
|
C00001615
|
Anthranoyllycoctonine
|
CHEMBL359227
CHEMBL451362 CHEMBL1499239 CHEMBL1968141 |
11 / 33 / 28 |
|
||
|
C00001617
|
Avadharidine
|
CHEMBL448609
|
|
|||
|
C00001618
|
Barbinine
|
|
||||
|
C00001624
|
Cashmiradelphine
|
CHEMBL454965
|
|
|||
|
C00001629
|
14-Deacetylnudicauline
|
CHEMBL443248
|
C086739
|
|
||
|
C00001630
|
Delavaine A
|
|
||||
|
C00001637
|
Elatine(alkaloid)
|
CHEMBL2113336
|
|
|||
|
C00001652
|
Lycaconitine
|
CHEMBL451640
|
C101813
|
|
||
|
C00001655
|
Methyllycaconitine
|
CHEMBL223494
CHEMBL387362 CHEMBL510275 CHEMBL1412391 CHEMBL1592980 CHEMBL1620703 CHEMBL1869403 CHEMBL2094019 |
C054634
|
21 / 12 / 8 | 15 / 7 |
|
|
C00001658
|
Nudicauline
|
CHEMBL2112854
|
|
|||
|
C00001662
|
Septentrionine
|
|
||||
|
C00028160
|
Delsemine A
|
|
||||
|
C00028161
|
Delsemine B
|
|
||||
|
C00028578
|
Methyllycaconitine
|
CHEMBL223494
CHEMBL387362 CHEMBL510275 CHEMBL1412391 CHEMBL1592980 CHEMBL1620703 CHEMBL1869403 CHEMBL2094019 |
C054634
|
21 / 12 / 8 | 15 / 7 |
|
|
C00028854
|
Potanidine A
|
|
||||
|
C00028855
|
Potanidine B
|
|
||||
|
C00032410
|
Trifoliolasine A
/ (+)-Trifoliolasine A |
|
||||
|
C00032411
|
Trifoliolasine B
/ (+)-Trifoliolasine B |
|
||||
|
C00032412
|
Trifoliolasine C
/ (+)-Trifoliolasine C |
|
||||
|
C00033086
|
Jiufengdine
/ (+)-Jiufengdine |
|
||||
|
C00033087
|
Jiufengtine
/ (+)-Jiufengtine |
|
||||
|
C00035462
|
14-Deacetyl-14-isobutyrylnudicauline
|
|
||||
|
C00035463
|
14-Demethyl-14-acetylanhweidelphinine
|
|
||||
|
C00035464
|
14-Demethyl-14-isobutyrylanhweidelphinine
|
|
||||
|
C00037016
|
Delavaine B
|
|
||||
|
C00043157
|
14-Deacetyl-14-isobutyrylajadine
/ (+)-14-Deacetyl-14-isobutyrylajadine |
|
||||
|
C00043256
|
Ajacine
|
CHEMBL1240989
|
|
|||
|
C00043541
|
Geyerline
/ (+)-Geyerline |
CHEMBL510876
|
|
|||
|
C00046559
|
14-Acetylbearline
|
CHEMBL507440
|
|
|||
|
C00046561
|
14-Deacetylajadine
|
CHEMBL1240987
|
|
|||
|
C00046563
|
16-Deacetylgeyerline
|
CHEMBL443248
|
|
|||
|
C00046606
|
Ajadine
|
CHEMBL1240988
|
|
|||
|
C00046629
|
Bearline
|
CHEMBL488301
|
|
|||
|
C00047305
|
Majusine A
/ (+)-Majusine A |
|
Human Protein / Gene in interactions
32 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001655 C00028578 | 1 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00001655 C00028578 | 2 / 0 |
| Q9UGM1 | Neuronal acetylcholine receptor subunit alpha-9 | CHRN alpha | C00001655 C00028578 | 0 / 0 |
| A5X5Y0 | 5-hydroxytryptamine receptor 3E | NS | C00001655 C00028578 | 0 / 0 |
| P23415 | Glycine receptor subunit alpha-1 | GLR alpha | C00001655 C00028578 | 1 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001655 C00028578 | 0 / 1 |
| P30926 | Neuronal acetylcholine receptor subunit beta-4 | CHRN beta | C00001655 C00028578 | 0 / 0 |
| P32297 | Neuronal acetylcholine receptor subunit alpha-3 | CHRN alpha | C00001655 C00028578 | 1 / 0 |
| P43681 | Neuronal acetylcholine receptor subunit alpha-4 | CHRN alpha | C00001655 C00028578 | 1 / 1 |
| P17787 | Neuronal acetylcholine receptor subunit beta-2 | CHRN beta | C00001655 C00028578 | 1 / 1 |
| O95264 | 5-hydroxytryptamine receptor 3B | NS | C00001655 C00028578 | 0 / 0 |
| Q70Z44 | 5-hydroxytryptamine receptor 3D | NS | C00001655 C00028578 | 0 / 0 |
| Q8WXA8 | 5-hydroxytryptamine receptor 3C | NS | C00001655 C00028578 | 0 / 0 |
| Q15822 | Neuronal acetylcholine receptor subunit alpha-2 | CHRN alpha | C00001655 C00028578 | 1 / 1 |
| P46098 | 5-hydroxytryptamine receptor 3A | NS | C00001655 C00028578 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001655 C00028578 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001655 C00028578 | 1 / 1 |
| P36544 | Neuronal acetylcholine receptor subunit alpha-7 | CHRN alpha | C00001655 C00028578 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001655 C00028578 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001655 C00028578 | 3 / 3 |
| Q9GZZ6 | Neuronal acetylcholine receptor subunit alpha-10 | CHRN alpha | C00001655 C00028578 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001615 | 2 / 2 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00001615 | 7 / 3 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001615 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00001615 | 2 / 5 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00001615 | 2 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00001615 | 2 / 2 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001615 | 0 / 0 |
| P07237 | Protein disulfide-isomerase | Enzyme | C00001615 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001615 | 11 / 10 |
| P04062 | Glucosylceramidase | Enzyme | C00001615 | 6 / 4 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001615 | 1 / 2 |
15 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00001655
C00028578
|
| 627 | BDNF, ANON2, BULN2 | brain-derived neurotrophic factor |
C00001655
C00028578
|
| 1137 | CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4 | cholinergic receptor, nicotinic, alpha 4 (neuronal) |
C00001655
C00028578
|
| 1139 | CHRNA7, CHRNA7-2, NACHRA7 | cholinergic receptor, nicotinic, alpha 7 (neuronal) |
C00001655
C00028578
|
| 1141 | CHRNB2, EFNL3, nAChRB2 | cholinergic receptor, nicotinic, beta 2 (neuronal) |
C00001655
C00028578
|
| 1621 | DBH, DBM | dopamine beta-hydroxylase (dopamine beta-monooxygenase) (EC:1.14.17.1) |
C00001655
C00028578
|
| 3674 | ITGA2B, BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3 | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) |
C00001655
C00028578
|
| 3690 | ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
C00001655
C00028578
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00001655
C00028578
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00001655
C00028578
|
| 4915 | NTRK2, GP145-TrkB, TRKB, trk-B | neurotrophic tyrosine kinase, receptor, type 2 (EC:2.7.10.1) |
C00001655
C00028578
|
| 6774 | STAT3, APRF, HIES | signal transducer and activator of transcription 3 (acute-phase response factor) |
C00001655
C00028578
|
| 7054 | TH, DYT14, DYT5b, TYH | tyrosine hydroxylase (EC:1.14.16.2) |
C00001655
C00028578
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00001655
C00028578
|
| 7538 | ZFP36, G0S24, GOS24, NUP475, RNF162A, TIS11, TTP, zfp-36 | ZFP36 ring finger protein |
C00001655
C00028578
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (45)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600513 | Epilepsy, nocturnal frontal lobe, 1; enfl1 |
P43681
|
| #605375 | Epilepsy, nocturnal frontal lobe, 3; enfl3 |
P17787
|
| #610353 | Epilepsy, nocturnal frontal lobe, 4; enfl4 |
Q15822
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #149400 | Hyperekplexia, hereditary 1; hkpx1 |
P23415
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #612052 | Smoking as a quantitative trait locus 3; sqtl3 |
P32297
|
KEGG DISEASE (36)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00807 | Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) |
P17787
(related)
P43681 (related) Q15822 (related) |
| H00769 | Hyperekplexia |
P23415
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
7 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001259 | Ataxia |
C00001655
C00028578 |
| D001919 | Bradycardia |
C00001655
C00028578 |
| D006973 | Hypertension |
C00001655
C00028578 |
| D018908 | Muscle Weakness |
C00001655
C00028578 |
| D012640 | Seizures |
C00001655
C00028578 |
| D013610 | Tachycardia |
C00001655
C00028578 |
| D014202 | Tremor |
C00001655
C00028578 |