KCF-S cluster No. 175 (34 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (34)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count

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Cumulative family count

class name	count
Streptomycetaceae	34
Actinomycetaceae	1

KEGG BRITE br08003

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Categories (0)

br08003 Category	# of metabolite

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metabolites link (0)

br08003 Category	KEGG ID	KNApSAcK ID

Metabolite list (34)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00016768	Cinerubin R		C078932
C00017167	Epelmycin A		C071800
C00017168	Epelmycin B		C071801
C00017169	Epelmycin C		C071802
C00017171	Epelmycin E / 11-Hydroxyaclacinomycin A	CHEMBL1965159
C00017173	Yellamycin B / Antibiotic Y 262-2		C071811
C00017179	Obelmycin E		C071808
C00017180	Obelmycin F / Rhodomycin X		C071807
C00017183	Alldimycin B / Alpharubicin II		C071814
C00017289	Betaclamycin B		C076090
C00018065	Aclacur / Jaclacin / NSC 208734 / Aclarubicin / Aclacinomycin A / Antibiotic 3082A / Antibiotic MA 144A1 / Antibiotic 77-3082A	CHEMBL45414 CHEMBL502620 CHEMBL2009694	D015250	91 / 38 / 33	10 / 3
C00018066	NSC 208735 / Aclarubicin B / Aclacinomycin B / Antibiotic MA 144B1 / Antibiotic 77-3082B	CHEMBL498884
C00018136	MA 144S2 / NSC 219941 / Musettamycin / Antibiotic MA 144S2	CHEMBL510497 CHEMBL504217	C015374
C00018140	Rhodirubin A
C00018141	Rhodirubin B
C00018223	Roseorubicin B
C00018226	Aclacinomycin Y / Antibiotic MA 144Y / Antibiotic 77-3082Y
C00018333	Sulfurmycin A		C034615
C00018334	Auramycin B		C034618
C00018335	Sulfurmycin B		C034616
C00018350	2-Hydroxyaclacinomycin A		C003424
C00018384	Trisarubicinol		C016788
C00018405	Auramycin A		C034617
C00018453	Auramycin C		C036705
C00018455	Auramycin E		C036707
C00018456	Auramycin F		C036708
C00018457	Auramycin G		C036709
C00018458	Sulfurmycin C		C036700
C00018460	Sulfurmycin E		C036702
C00018461	Sulfurmycin F		C036703
C00018462	Sulfurmycin G		C036704
C00018597	Betaclamycin M
C00018598	Betaclamycin N
C00018599	CG 21B / CG 18B / Betaclamycin S

Human Protein / Gene in interactions

91 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00018065	1 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00018065	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00018065	0 / 3
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00018065	2 / 2
P08246	Neutrophil elastase	S1A	C00018065	2 / 1
P33765	Adenosine receptor A3	Adenosine receptor	C00018065	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00018065	0 / 0
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00018065	0 / 0
P29466	Caspase-1	C14	C00018065	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00018065	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00018065	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00018065	2 / 2
P00918	Carbonic anhydrase 2	Lyase	C00018065	1 / 2
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00018065	0 / 1
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00018065	1 / 1
P25021	Histamine H2 receptor	Histamine receptor	C00018065	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00018065	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00018065	1 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00018065	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00018065	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00018065	0 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00018065	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00018065	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00018065	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00018065	0 / 1
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00018065	1 / 8
P14416	D(2) dopamine receptor	Dopamine receptor	C00018065	2 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00018065	0 / 0
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00018065	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00018065	0 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00018065	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00018065	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00018065	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00018065	1 / 1
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00018065	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00018065	1 / 0
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00018065	0 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00018065	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00018065	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00018065	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00018065	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00018065	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00018065	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00018065	0 / 1
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00018065	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00018065	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00018065	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00018065	1 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00018065	0 / 0
P08311	Cathepsin G	S1A	C00018065	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00018065	1 / 0
P03956	Interstitial collagenase	M10A	C00018065	0 / 1
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00018065	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00018065	0 / 1
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00018065	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00018065	0 / 0
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00018065	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00018065	2 / 0
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00018065	5 / 9
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00018065	1 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00018065	0 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00018065	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00018065	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00018065	0 / 0
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00018065	1 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00018065	0 / 0
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00018065	2 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00018065	0 / 0
P08253	72 kDa type IV collagenase	M10A	C00018065	1 / 3
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00018065	0 / 0
P03372	Estrogen receptor	NR3A1	C00018065	1 / 1
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00018065	1 / 0
P22303	Acetylcholinesterase	Hydrolase	C00018065	1 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00018065	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00018065	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00018065	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00018065	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00018065	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00018065	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00018065	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00018065	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00018065	0 / 1
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00018065	0 / 0
P07477	Trypsin-1	S1A	C00018065	1 / 1
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00018065	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00018065	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00018065	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00018065	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00018065	1 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00018065	0 / 1
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00018065	0 / 0

10 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00018065
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00018065
1676	DFFA, DFF-45, DFF1, ICAD	DNA fragmentation factor, 45kDa, alpha polypeptide	C00018065
2623	GATA1, ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT	GATA binding protein 1 (globin transcription factor 1)	C00018065
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00018065
3145	HMBS, PBG-D, PBGD, PORC, UPS	hydroxymethylbilane synthase (EC:2.5.1.61)	C00018065
4778	NFE2, NF-E2, p45	nuclear factor, erythroid 2	C00018065
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00018065
6647	SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	C00018065
331	XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3	X-linked inhibitor of apoptosis	C00018065

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions