KCF-S cluster No. 176 (34 metabolites)

Corresponding Phytochemical cluster No. 58

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (34)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	40

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Cumulative family count

class name	count
Solanaceae	40

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Others	2

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metabolites link (2)

br08003 Category	KEGG ID	KNApSAcK ID
Others	C08841	C00003676
Others	C08842	C00003677

Metabolite list (34)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00003676	Withaferin A	CHEMBL517080 CHEMBL578716 CHEMBL1221986 CHEMBL1419012 CHEMBL2143369	C009684	27 / 22 / 15	7 / 2
C00003677	Withaferin D / Withanolide D	CHEMBL1222037	C010376	2 / 0 / 0
C00031020	Physagulin L / (+)-Physagulin L
C00031534	Dihydrowithaferin A / 2,3-Dihydrowithaferin A	CHEMBL1934585
C00032513	Withanolide A / (+)-Withanolide A	CHEMBL445041
C00033134	Lycium substance B
C00034339	Withanone	CHEMBL516703
C00035011	27-Hydroxywithanone
C00035165	Withastramonolide
C00035210	17-Hydroxy withaferin A	CHEMBL2047414
C00038018	Withacnistin
C00038151	12-O-Methyl jaborosotetrol
C00038208	20-Hydroxytubocapsanolide A	CHEMBL447848
C00038215	23-Hydroxytubocapsanolide A / (-)-23-Hydroxytubocapsanolide A	CHEMBL389413
C00039032	Dihydrowithanolide E / 2,3-Dihydrowithanolide E
C00039474	Jaborotetrol	CHEMBL1099356
C00040544	Trechonolide A / (+)-Trechonolide A	CHEMBL1099355
C00040573	Tubocapsanolide A / (+)-Tubocapsanolide A	CHEMBL227900
C00040574	Tubocapsanolide D / (+)-Tubocapsanolide D
C00040575	Tubocapsanolide F / (+)-Tubocapsanolide F
C00040653	Withangulatin B / (+)-Withangulatin B	CHEMBL390851
C00040654	Withangulatin C / (-)-Withangulatin C	CHEMBL390641
C00040655	Withangulatin D / (-)-Withangulatin D
C00040656	Withangulatin E / (+)-Withangulatin E
C00040658	Withangulatin G / (+)-Withangulatin G	CHEMBL230882
C00040659	Withangulatin H / (-)-Withangulatin H	CHEMBL387565
C00040752	(20S,22R)-5beta,6beta-Epoxy-4beta,14beta,15alpha-trihydroxy-1-oxowith-2,24-dienolide / (+)-(20S,22R)-5beta,6beta-Epoxy-4beta,14beta,15alpha-trihydroxy-1-oxowith-2,24-dienolide
C00041760	Physacoztolide A / (+)-Physacoztolide A
C00041761	Physacoztolide B / (+)-Physacoztolide B
C00041762	Physacoztolide C / (+)-Physacoztolide C
C00044015	Withaphysalin M / (+)-Withaphysalin M	CHEMBL450392
C00044016	Withaphysalin N / (-)-Withaphysalin N	CHEMBL502237
C00049629	Daturolactone 5 / (-)-Daturolactone 5
C00049631	Daturolactone 7 / (-)Daturolactone 7

Human Protein / Gene in interactions

27 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P07355	Annexin A2	Unclassified protein	C00003676 C00003677	0 / 0
P11142	Heat shock cognate 71 kDa protein	Unclassified protein	C00003676 C00003677	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00003676	1 / 1
P06746	DNA polymerase beta	Enzyme	C00003676	0 / 0
P42574	Caspase-3	C14	C00003676	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00003676	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00003676	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00003676	2 / 3
P42858	Huntingtin	Unclassified protein	C00003676	1 / 1
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00003676	2 / 0
O75496	Geminin	Unclassified protein	C00003676	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00003676	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00003676	1 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00003676	2 / 0
P17861	X-box-binding protein 1	Unclassified protein	C00003676	1 / 0
O15118	Niemann-Pick C1 protein	Unclassified protein	C00003676	1 / 1
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00003676	0 / 0
P31749	RAC-alpha serine/threonine-protein kinase	Akt	C00003676	4 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00003676	0 / 0
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00003676	1 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00003676	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00003676	4 / 3
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00003676	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00003676	1 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00003676	1 / 0
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00003676	0 / 3
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00003676	2 / 1

7 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
468	ATF4, CREB-2, CREB2, TAXREB67, TXREB	activating transcription factor 4	C00003676
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00003676
1649	DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153	DNA-damage-inducible transcript 3	C00003676
54541	DDIT4, Dig2, REDD-1, REDD1	DNA-damage-inducible transcript 4	C00003676
83939	EIF2A, EIF-2A, MST089, MSTP004, MSTP089	eukaryotic translation initiation factor 2A, 65kDa	C00003676
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00003676
7494	XBP1, TREB5, XBP-1, XBP2	X-box binding protein 1	C00003676

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions