PCIDB

KCF-S cluster No. 1801 (6 metabolites)

class name	count
rosids	9
asterids	1

br08003 Category	# of metabolite

br08003 Category	KEGG ID	KNApSAcK ID

KNApSAcK ID	name	ChEMBL link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE
C00006995	Licodione 2'-methyl ether
C00006996	2',6',beta-Trihydroxy-4'-methoxychalcone
C00006997	2',4',beta-Trihydroxy-6'-methoxychalcone
C00019287	Cearoin / 2,5-Dihydroxy-4-methoxybenzophenone	CHEMBL1613209	10 / 22 / 22
C00035788	2,6-Dihydroxy-4-methoxybenzophenone
C00044468	6,3'-Dihydroxy-2,4-dimethoxybenzophenone

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P02545	Prelamin-A/C	Unclassified protein	C00019287	11 / 10
P11473	Vitamin D3 receptor	NR1I1	C00019287	2 / 3
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00019287	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00019287	3 / 3
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00019287	2 / 2
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00019287	0 / 1
P10636	Microtubule-associated protein tau	Unclassified protein	C00019287	4 / 3
Q9UBT6	DNA polymerase kappa	Enzyme	C00019287	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00019287	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00019287	0 / 0

OMIM	preferred title	UniProt
#300438	17-beta-hydroxysteroid dehydrogenase x deficiency	Q99714
#115200	Cardiomyopathy, dilated, 1a; cmd1a	P02545
#212112	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	P02545
#605588	Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1	P02545
#119900	Digital clubbing, isolated congenital	P15428
#181350	Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2	P02545
#600274	Frontotemporal dementia; ftd	P10636
#610140	Heart-hand syndrome, slovenian type	P02545
#176670	Hutchinson-gilford progeria syndrome; hgps	P02545
#259100	Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1	P15428
#151660	Lipodystrophy, familial partial, type 2; fpld2	P02545
#248370	Mandibuloacral dysplasia with type a lipodystrophy; mada	P02545
#300705	Mental retardation, x-linked 17; mrx17	Q99714
#300220	Mental retardation, x-linked, syndromic 10; mrxs10	Q99714
#613205	Muscular dystrophy, congenital, lmna-related	P02545
#159001	Muscular dystrophy, limb-girdle, type 1b; lgmd1b	P02545
#607948	Mycobacterium tuberculosis, susceptibility to	P11473
#260540	Parkinson-dementia syndrome	P10636
#172700	Pick disease of brain	P10636
#275210	Restrictive dermopathy, lethal	P02545
#601104	Supranuclear palsy, progressive, 1; psnp1	P10636
#277440	Vitamin d-dependent rickets, type 2a; vddr2a	P11473

KEGG	name	UniProt
H00264	Charcot-Marie-Tooth disease (CMT)	P02545 (related)
H00294	Dilated cardiomyopathy (DCM)	P02545 (related)
H00420	Familial partial lipodystrophy (FPL)	P02545 (related)
H00563	Emery-Dreifuss muscular dystrophy	P02545 (related)
H00590	Congenital muscular dystrophies (CMD/MDC)	P02545 (related)
H00593	Limb-girdle muscular dystrophy (LGMD)	P02545 (related)
H00601	Hutchinson-Gilford progeria syndrome	P02545 (related)
H00663	Restrictive dermopathy	P02545 (related)
H00665	Mandibuloacral dysplasia	P02545 (related)
H01216	Left ventricular noncompaction (LVNC)	P02545 (related)
H00036	Osteosarcoma	P08684 (marker)
H00058	Amyotrophic lateral sclerosis (ALS)	P10636 (related)
H00077	Progressive supranuclear palsy (PSP)	P10636 (related)
H00078	Frontotemporal lobar degeneration (FTLD)	P10636 (related)
H00342	Tuberculosis	P11473 (related)
H00784	Localized autosomal recessive hypotrichosis	P11473 (related)
H01143	Vitamin D-dependent rickets	P11473 (related)
H00457	Primary hypertrophic osteoarthropathy (PHO)	P15428 (related)
H01246	Isolated congenital nail clubbing (ICNC)	P15428 (related)
H00480	Non-syndromic X-linked mental retardation	Q99714 (related)
H00658	Syndromic X-linked mental retardation	Q99714 (related)
H00925	2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency	Q99714 (related)