PCIDB

KCF-S cluster No. 1844 (6 metabolites)

Corresponding Phytochemical cluster No. 11

Plant Species

Cumulative plant class count

class name count
Liliopsida 15

Cumulative family count

class name count
Melanthiaceae 13
Liliaceae 2

KEGG BRITE br08003 External link 512

Categories (1)

br08003 Category # of metabolite
Steroid alkaloids 1

metabolites link (1)

br08003 Category KEGG ID KNApSAcK ID
Steroid alkaloids C10798 C00002245

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00002245 External link 512 Cyclopamine
CHEMBL254129
CHEMBL1590308
CHEMBL2132004
C000541
7 / 9 / 14 0 / 8
C00028175 External link 512 Diacetylveralkamine
/ O,O-Diacetylveralkamine
C00029185 External link 512 Veralinine
C00029186 External link 512 Veralkamine
C00029189 External link 512 Veralomidine
C00029196 External link 512 Veramine

Human Protein / Gene in interactions

7 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q15465 Sonic hedgehog protein Unclassified protein C00002245 4 / 5
P11473 Vitamin D3 receptor NR1I1 C00002245 2 / 3
P08151 Zinc finger protein GLI1 Unclassified protein C00002245 0 / 0
P30518 Vasopressin V2 receptor Vasopressin and oxytocin receptor C00002245 2 / 2
Q99835 Smoothened homolog Smoothened receptor (frizzled family GPCR) C00002245 0 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00002245 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002245 1 / 4

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (9)

OMIM preferred title UniProt
#304800 Diabetes insipidus, nephrogenic, x-linked P30518
#142945 Holoprosencephaly 3; hpe3 Q15465
#611638 Microphthalmia, isolated, with coloboma 5; mcopcb5 Q15465
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#300539 Nephrogenic syndrome of inappropriate antidiuresis; nsiad P30518
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#174500 Polydactyly, preaxial ii; ppd2 Q15465
#147250 Solitary median maxillary central incisor; smmci Q15465
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (14)

KEGG name UniProt
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00252 Congenital nephrogenic diabetes insipidus (NDI) P30518 (related)
H01294 Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) P30518 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00039 Basal cell carcinoma Q15465 (related)
Q99835 (related)
H00267 Holoprosencephaly (HPE) Q15465 (related)
H00652 Solitary median maxillary central incisor syndrome Q15465 (related)
H01027 Anophthalmia and microphthalmia (A/M) Q15465 (related)
H01160 Schizencephaly Q15465 (related)

Diseases related to CTD interactions

8 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000014 Abnormalities, Drug-Induced C00002245
D002971 Cleft Lip C00002245
D002972 Cleft Palate C00002245
D019465 Craniofacial Abnormalities C00002245
D004487 Edema C00002245
D016142 Holoprosencephaly C00002245
D007569 Jaw Abnormalities C00002245
D049188 Prenatal Injuries C00002245