KCF-S cluster No. 21 (132 metabolites)

Corresponding Phytochemical cluster No. 11

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (132)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Liliopsida	111
asterids	62
rosids	11
eudicotyledons	7

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Cumulative family count

class name	count
Solanaceae	56
Dioscoreaceae	40
Asparagaceae	36
Smilacaceae	12
Mycalidae	10
Amaryllidaceae	10
Zygophyllaceae	9
Arecaceae	6
Plantaginaceae	5
Melanthiaceae	4
Ranunculaceae	3
Poaceae	2
Amaranthaceae	2
Basellaceae	2
Fabaceae	2
Lamiaceae	1
Xanthorrhoeaceae	1

KEGG BRITE br08003

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Categories (3)

br08003 Category	# of metabolite
Steroid alkaloids	2
Furostan	12
Spirostan	4

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metabolites link (18)

br08003 Category	KEGG ID	KNApSAcK ID
Steroid alkaloids	C10803	C00002248
Steroid alkaloids	C10827	C00002268
Furostan	C08887	C00003564
Furostan	C08888	C00003565
Furostan	C08889	C00003566
Furostan	C08892	C00003569
Furostan	C08895	C00003572
Spirostan	C00765	C00003574
Spirostan	C08900	C00003578
Spirostan	C08906	C00003584
Furostan	C08907	C00003585
Furostan	C08908	C00003586
Furostan	C08910	C00003588
Furostan	C08911	C00003589
Spirostan	C08915	C00003594
Furostan	C08917	C00003596
Furostan	C17468	C00030764
Furostan	C17469	C00031101

Metabolite list (132)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002248	Demissine
C00002268	Tomatine	CHEMBL525778 CHEMBL2007040	D014053
C00003564	Avenacoside A
C00003565	Avenacoside B
C00003566	Capsicoside A
C00003569	Convallamaroside
C00003572	Deltoside
C00003574	Digitonin	CHEMBL404811 CHEMBL509531 CHEMBL2005540	D004072	105 / 60 / 67
C00003578	Gitonin	CHEMBL510031 CHEMBL1971976	C029021
C00003584	Parillin
C00003585	Protodioscin / 3beta,22alpha,26-Trihydroxyfurost-5-ene-3-O-beta-chacotrioside-26-O-beta-D-glucopyranoside	CHEMBL1163175 CHEMBL1981285 CHEMBL1995734
C00003586	Protogracillin	CHEMBL1164913 CHEMBL2071193
C00003588	Ruscoside
C00003589	Sarsaparilloside
C00003594	Tigonin
C00003596	Protoneodioscin / Trigonelloside C	CHEMBL1163175 CHEMBL1981285 CHEMBL1995734
C00024130	Chinenoside II
C00024132	Chinenoside IV
C00025493	Dehydrocommersonine / 5,6-Didehydrocommersonine
C00028512	Lycoperoside A / (23R)-23-Acetoxytomatidine
C00028513	Lycoperoside B / (23S)-23-Acetoxysoladulcidine
C00028514	Lycoperoside C / (23S,25S)-23-Acetoxy-5alpha,22alphaN-Spirosolan-3beta-ol
C00029314	(25S)-Kingianoside E
C00029315	(25S)-Kingianoside F
C00029746	Asparoside A / Curilloside G
C00030135	Dioscoreside A / (-)-Dioscoreside A
C00030136	Dioscoreside B / (-)-Dioscoreside B
C00030137	Dioscoreside C / (-)-Dioscoreside C
C00030138	Hypoglaucin G / Dioscoreside D / (-)-Dioscoreside D	CHEMBL500446 CHEMBL1971803
C00030139	Dioscoreside E
C00030216	Esculeoside A	CHEMBL1269162
C00030217	Esculeoside B
C00030218	Esculeoside C
C00030219	Esculeoside D
C00030511	Indioside D	CHEMBL1164913 CHEMBL2071193
C00030619	Kingianoside E
C00030620	Kingianoside F
C00030698	Lycoperoside G
C00030762	Methyl parvifloside
C00030764	Smilax saponin B / Methylprotodioscin / Methyl protodioscin / (-)-Methylprotodioscin	CHEMBL453625 CHEMBL1993106 CHEMBL2004298
C00030765	Methyl protogracillin	CHEMBL506321 CHEMBL1975726 CHEMBL1976461
C00030766	Methyl protoneodioscin	CHEMBL453625 CHEMBL1993106 CHEMBL2004298
C00030822	Nigroside A
C00030931	Parvifloside
C00031090	Protoneogracillin	CHEMBL1164913 CHEMBL2071193
C00031101	Pseudoprotodioscin / (-)-Pseudoprotodioscin
C00031102	Pseudoprotogracillin
C00031103	Pseudoprotoneodioscin
C00031174	Riparoside A / (-)-Riparoside A
C00031175	Riparoside B
C00031541	26-O-beta-D-glucopyranosyl-(25R)-3beta,22xi,26-trihydroxy-5alpha-furostane 3-O-beta-chacotrioside
C00031599	Anguivioside XV
C00031991	Lycoperoside F	CHEMBL1269162
C00032187	Spongioside A / (-)-Spongioside A	CHEMBL486480
C00032188	Spongioside B
C00032413	Trigofoenoside D-1	CHEMBL506321 CHEMBL1975726 CHEMBL1976461
C00032680	Abutiloside D / (-)-Abutiloside D
C00032681	Abutiloside E / (-)-Abutiloside E
C00032904	Desgalactotigonin / (-)-Desgalactotigonin	CHEMBL454566 CHEMBL505764	C092288
C00033017	Hemeroside B / (-)-Hemeroside B
C00033248	Nigrumnin I	CHEMBL1994250
C00033249	Nigrumnin II / (-)-Nigrumnin II
C00033445	Trigoneoside XIIIa / (-)-Trigoneoside XIIIa
C00033807	Elephanoside B / (-)-Elephanoside B
C00033808	Elephanoside C / (+)-Elephanoside C
C00033811	Elephanoside F / (-)-Elephanoside F
C00033903	Hellebosaponin A / (-)-Hellebosaponin A	CHEMBL504992
C00033904	Hellebosaponin B
C00034241	Shatavarin I / Asparoside B / (-)-Asparoside B
C00034246	Shatavarin VIII / (-)-Shatavarin VIII
C00034330	Tribulosin	CHEMBL1994250
C00035154	Racemoside A / (-)-Racemoside A
C00035730	Pseudoproto-Pb	CHEMBL2071191
C00035867	Pentandroside F / (-)-Pentandroside F
C00035868	Pentandroside G
C00036025	Abutiloside L
C00036026	Abutiloside M / (-)-Abutiloside M
C00036027	Abutiloside N / (-)-Abutiloside N
C00040571	Tuberoside B(Allium)
C00040572	Tuberoside C(Allium) / (-)-Tuberoside C(Allium)
C00041691	Neosibiricoside A / (-)-Neosibiricoside A	CHEMBL450738
C00041692	Neosibiricoside B / (-)-Neosibiricoside B
C00041693	Neosibiricoside C / (-)-Neosibiricoside C
C00041868	Solanigroside C / (-)-Solanigroside C	CHEMBL509104
C00041869	Solanigroside D / (-)-Solanigroside D	CHEMBL506199
C00041870	Solanigroside E / (-)-Solanigroside E	CHEMBL501125
C00041871	Solanigroside F / (-)-Solanigroside F	CHEMBL526905
C00041872	Solanigroside G / (-)-Solanigroside G	CHEMBL448027
C00041873	Solanigroside H / (-)-Solanigroside H	CHEMBL449197
C00042830	Parvispinoside A / (+)-Parvispinoside A	CHEMBL525242 CHEMBL1968031
C00042831	Parvispinoside B / (-)-Parvispinoside B	CHEMBL499185 CHEMBL447445
C00043250	Agamenoside F	CHEMBL507964
C00043295	Asparacoside	CHEMBL509187
C00043689	Lycoperoside H
C00043825	Polianthoside B / (-)-Polianthoside B	CHEMBL502761
C00043826	Polianthoside C / (-)-Polianthoside C	CHEMBL507534
C00043827	Polianthoside D / (-)-Polianthoside D	CHEMBL525992
C00043828	Polianthoside E / (-)-Polianthoside E	CHEMBL526485
C00043829	Polianthoside F / (-)-Polianthoside F	CHEMBL508568
C00043830	Polianthoside G	CHEMBL510571
C00043995	Uttroside B	CHEMBL499185 CHEMBL447445
C00044513	Ajugasalicioside H / (-)-Ajugasalicioside H	CHEMBL450854
C00044941	Mycaloside B / (-)-Mycaloside B
C00044942	Mycaloside C / (-)-Mycaloside C
C00044943	Mycaloside D / (-)-Mycaloside D
C00044944	Mycaloside E / (-)-Mycaloside E
C00044945	Mycaloside F / (-)-Mycaloside F
C00044946	Mycaloside G / (-)-Mycaloside G
C00044947	Mycaloside H / (-)-Mycaloside H
C00044948	Mycaloside I / (-)-Mycaloside I
C00045121	Triquetroside A1 / (-)-Triquetroside A1
C00045122	Triquetroside A2 / (-)-Triquetroside A2
C00045123	Triquetroside B / (-)-Triquetroside B
C00045637	Anguivioside XI / (-)-Anguivioside XI
C00045638	Anguivioside XVI / (-)-Anguivioside XVI
C00046181	Namonin A / (-)-Namonin A	CHEMBL524307
C00046182	Namonin B / (-)-Namonin B	CHEMBL502088
C00046185	Namonin E / (-)-Namonin E	CHEMBL504203
C00047193	Borivilianoside G / (-)-Borivilianoside G
C00047194	Borivilianoside H / (-)-Borivilianoside H	CHEMBL555735
C00048332	Bethoside A / (-)-Bethoside A
C00048597	Aginoside	CHEMBL444456
C00048640	CAY-1	CHEMBL1988088
C00048781	Mycaloside J
C00048782	Mycaloside K / (-)-Mycaloside K
C00048890	TTS-12	CHEMBL1994250
C00049972	Aculeoside B / (-)-Aculeoside B	CHEMBL504592
C00050278	Brodiosaponin B / (-)-Brodiosaponin B
C00050279	Brodiosaponin C / (-)-Brodiosaponin C
C00050280	Brodiosaponin D / (-)-Brodiosaponin D
C00050281	Brodiosaponin E / (-)-Brodiosaponin E
C00050282	Brodiosaponin F / (-)-Brodiosaponin F

Human Protein / Gene in interactions

105 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00003574	1 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00003574	7 / 37
Q16637	Survival motor neuron protein	Unclassified protein	C00003574	4 / 1
P21728	D(1A) dopamine receptor	Dopamine receptor	C00003574	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00003574	0 / 3
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00003574	2 / 2
P08246	Neutrophil elastase	S1A	C00003574	2 / 1
P33765	Adenosine receptor A3	Adenosine receptor	C00003574	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00003574	0 / 0
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00003574	0 / 0
P29466	Caspase-1	C14	C00003574	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00003574	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00003574	0 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00003574	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00003574	2 / 2
P16473	Thyrotropin receptor	Glycohormone receptor	C00003574	3 / 2
P10828	Thyroid hormone receptor beta	NR1A2	C00003574	3 / 1
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00003574	0 / 0
P00918	Carbonic anhydrase 2	Lyase	C00003574	1 / 2
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00003574	0 / 1
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00003574	1 / 1
P25021	Histamine H2 receptor	Histamine receptor	C00003574	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00003574	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00003574	1 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00003574	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00003574	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00003574	0 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00003574	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00003574	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00003574	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00003574	0 / 1
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00003574	1 / 8
P11473	Vitamin D3 receptor	NR1I1	C00003574	2 / 3
P14416	D(2) dopamine receptor	Dopamine receptor	C00003574	2 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00003574	0 / 0
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00003574	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00003574	0 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00003574	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00003574	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00003574	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00003574	1 / 1
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00003574	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00003574	1 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00003574	0 / 0
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00003574	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00003574	0 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00003574	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00003574	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00003574	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00003574	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00003574	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00003574	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00003574	0 / 1
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00003574	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00003574	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00003574	0 / 0
P10145	Interleukin-8	Secreted protein	C00003574	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00003574	1 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00003574	0 / 0
P08311	Cathepsin G	S1A	C00003574	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00003574	1 / 0
P03956	Interstitial collagenase	M10A	C00003574	0 / 1
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00003574	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00003574	0 / 1
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00003574	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00003574	0 / 0
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00003574	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00003574	2 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00003574	5 / 3
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00003574	5 / 9
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00003574	1 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00003574	0 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00003574	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00003574	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00003574	0 / 0
Q96RI1	Bile acid receptor	NR1H4	C00003574	0 / 0
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00003574	1 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00003574	0 / 0
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00003574	2 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00003574	0 / 0
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00003574	0 / 0
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00003574	0 / 0
P03372	Estrogen receptor	NR3A1	C00003574	1 / 1
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00003574	1 / 0
P22303	Acetylcholinesterase	Hydrolase	C00003574	1 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00003574	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00003574	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00003574	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00003574	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00003574	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00003574	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00003574	0 / 0
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00003574	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00003574	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00003574	0 / 1
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00003574	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00003574	0 / 0
P10275	Androgen receptor	NR3C4	C00003574	3 / 4
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00003574	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00003574	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00003574	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00003574	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00003574	1 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00003574	0 / 1
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00003574	0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions