KCF-S cluster No. 220 (29 metabolites)

Corresponding Phytochemical cluster No. 11

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (29)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	65
asterids	7

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Cumulative family count

class name	count
Cucurbitaceae	38
Elaeocarpaceae	8
Begoniaceae	7
Plantaginaceae	6
Brassicaceae	4
Tricholomataceae	3
Rosaceae	3
Malvaceae	3
Chrysobalanaceae	1
Salicaceae	1
Chrysomelidae	1
Columelliaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Cycloartane	14

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metabolites link (14)

br08003 Category	KEGG ID	KNApSAcK ID
Cycloartane	C08793	C00003682
Cycloartane	C08794	C00003683
Cycloartane	C08795	C00003684
Cycloartane	C08796	C00003685
Cycloartane	C08797	C00003686
Cycloartane	C08798	C00003687
Cycloartane	C08799	C00003688
Cycloartane	C08800	C00003689
Cycloartane	C08801	C00003690
Cycloartane	C08803	C00003691
Cycloartane	C08804	C00003692
Cycloartane	C08805	C00003693
Cycloartane	C08807	C00003695
Cycloartane	C08802	C00031750

Metabolite list (29)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00003682	Cucurbitacin A	CHEMBL455518		1 / 1 / 2
C00003683	Cucurbitacin B	CHEMBL367917 CHEMBL508185 CHEMBL507237 CHEMBL1708265 CHEMBL1728549	C041246	22 / 30 / 28
C00003684	Cucurbitacin C	CHEMBL449220 CHEMBL1355541		12 / 9 / 9
C00003685	Cucurbitacin D	CHEMBL493646 CHEMBL492404	C038105	1 / 0 / 0
C00003686	Cucurbitacin E	CHEMBL455056	C102326	3 / 1 / 2
C00003687	Cucurbitacin F	CHEMBL488312 CHEMBL1730681	C453923	8 / 4 / 1
C00003688	Cucurbitacin H	CHEMBL551160 CHEMBL1163012		1 / 1 / 2
C00003689	Cucurbitacin I	CHEMBL387737 CHEMBL1317135 CHEMBL1717364	C038106	20 / 15 / 15	2 / 0
C00003690	Cucurbitacin J	CHEMBL1923789 CHEMBL1923790 CHEMBL1984707
C00003691	Cucurbitacin O	CHEMBL488312 CHEMBL1730681		8 / 4 / 1
C00003692	Cucurbitacin P	CHEMBL422755 CHEMBL486260
C00003693	Cucurbitacin Q	CHEMBL447610 CHEMBL1965785
C00003695	11-Deoxocucurbitacin I
C00030028	Cucurbitacin B 2-sulfate
C00031748	Dihydrocucurbitacin B	CHEMBL553851		1 / 1 / 2
C00031749	Dihydrocucurbitacin E	CHEMBL256519
C00031750	Dihydrocucurbitacin I	CHEMBL480111		1 / 0 / 0
C00034445	Bacobitacin A / (-)-Bacobitacin A
C00034446	Bacobitacin B / (-)-Bacobitacin B
C00035843	Isocucurbitacin R	CHEMBL563715		1 / 1 / 2
C00039029	Hemslecin B / Dihydrocucurbitacin F	CHEMBL422755 CHEMBL486260
C00041248	16-Deoxycucurbitacin B / (+)-16-Deoxycucurbitacin B	CHEMBL503027
C00044429	25-Acetylcucurbitacin F	CHEMBL506658
C00044430	2-Deoxycucurbitacin D	CHEMBL493647
C00046712	Deacetylpicracin	CHEMBL487390
C00046860	Picracin	CHEMBL506658
C00047823	Cucurbitacin G	CHEMBL551160 CHEMBL1163012		1 / 1 / 2
C00047824	Cucurbitacin R	CHEMBL403003 CHEMBL564629		2 / 1 / 2
C00047845	Dihydroisocucurbitacin B	CHEMBL556138		1 / 1 / 2

Human Protein / Gene in interactions

34 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P40763	Signal transducer and activator of transcription 3	Transcription Factor	C00003682 C00003683 C00003686 C00003688 C00031748 C00035843 C00047823 C00047824 C00047845	1 / 2
P20701	Integrin alpha-L	Membrane receptor	C00003683 C00003685 C00003686 C00003689 C00031750 C00047824	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00003683 C00003684 C00003687 C00003689 C00003691	1 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00003683 C00003684 C00003687 C00003689 C00003691	1 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00003683 C00003684 C00003687 C00003689 C00003691	2 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00003683 C00003684 C00003687 C00003689 C00003691	0 / 0
O75496	Geminin	Unclassified protein	C00003683 C00003684 C00003687 C00003689 C00003691	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00003683 C00003684 C00003687 C00003691	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00003683 C00003687 C00003689 C00003691	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00003683 C00003684 C00003689	2 / 3
P83916	Chromobox protein homolog 1	Unclassified protein	C00003683 C00003687 C00003691	0 / 0
Q06710	Paired box protein Pax-8	Unclassified protein	C00003683 C00003684 C00003689	1 / 2
O15118	Niemann-Pick C1 protein	Unclassified protein	C00003683 C00003684	1 / 1
Q16637	Survival motor neuron protein	Unclassified protein	C00003683 C00003689	4 / 1
P51151	Ras-related protein Rab-9A	Unclassified protein	C00003683 C00003684	0 / 0
P23528	Cofilin-1	Unclassified protein	C00003686 C00003689	0 / 0
P42858	Huntingtin	Unclassified protein	C00003683	1 / 1
P11387	DNA topoisomerase 1	Isomerase	C00003683	0 / 0
P11308	Transcriptional regulator ERG	Unclassified protein	C00003689	1 / 2
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00003684	1 / 2
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00003689	0 / 1
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00003683	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00003689	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00003689	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00003683	11 / 10
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00003689	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00003689	0 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00003684	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00003683	4 / 3
Q13315	Serine-protein kinase ATM	Atypical serine/threonine protein kinase PIKK subfamily	C00003683	1 / 4
P31939	Bifunctional purine biosynthesis protein PURH	Enzyme	C00003689	1 / 1
P39748	Flap endonuclease 1	Enzyme	C00003683	0 / 0
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00003689	0 / 3
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00003689	1 / 0

2 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
3717	JAK2, JTK10, THCYT3	Janus kinase 2 (EC:2.7.10.2)	C00003689
6774	STAT3, APRF, HIES	signal transducer and activator of transcription 3 (acute-phase response factor)	C00003689

Related Diseases

Diseases related to proteins in ChEMBL interactions