| class name | count |
|---|
| class name | count |
|---|---|
| Dermateaceae | 4 |
| Pleosporaceae | 1 |
| br08003 Category | # of metabolite |
|---|
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00016325
|
F 10863A
/ Zaragozic acid D3 / Squalene synthase inhibitor compd. A |
|
||||
|
C00016326
|
F 10863B
|
|
||||
|
C00016327
|
F 10863C
|
|
||||
|
C00016328
|
F 10863D
|
|
||||
|
C00016820
|
L 694599
/ GR 105155X / Squalestatin / Squalestatin 1 / Squalestatin S1 / Zaragozic acid A |
CHEMBL280978
CHEMBL40991 CHEMBL302601 CHEMBL86319 CHEMBL434998 CHEMBL1477148 CHEMBL1886451 |
C075117
|
8 / 11 / 9 |
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P37268 | Squalene synthase | Enzyme | C00016820 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00016820 | 1 / 2 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00016820 | 2 / 3 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00016820 | 0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00016820 | 4 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00016820 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00016820 | 4 / 3 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00016820 | 0 / 0 |
| OMIM | preferred title | UniProt |
|---|---|---|
| #210900 | Bloom syndrome; blm |
P54132
|
| #114480 | Breast cancer |
P31749
|
| #114500 | Colorectal cancer; crc |
P31749
|
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #176920 | Proteus syndrome |
P31749
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| KEGG | name | UniProt |
|---|---|---|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|