PCIDB

KCF-S cluster No. 2366 (5 metabolites)

KEGG BRITE br08003 External link 512

Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00000143 External link 512 3-Hydroxyuridine
C00016743 External link 512 NSC 518132
/ Thiouridine
/ 4-Thiouridine
CHEMBL390500
CHEMBL1330220
D013891
5 / 2 / 1 0 / 1
C00019674 External link 512 Uridine
CHEMBL68846
CHEMBL100259
CHEMBL265701
CHEMBL608294
CHEMBL609651
CHEMBL1092065
CHEMBL2093066
D014529
5 / 0 / 3 7 / 15
C00033569 External link 512 4-Selenouridine
C00042440 External link 512 Cytidine
CHEMBL6592
CHEMBL78
CHEMBL803
CHEMBL95606
CHEMBL1315342
CHEMBL2028065
CHEMBL2092816
CHEMBL2093067
D003562
115 / 62 / 54 2 / 1

Human Protein / Gene in interactions

119 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00016743 C00019674 C00042440 0 / 0
Q9HA47 Uridine-cytidine kinase 1 Enzyme C00019674 C00042440 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00019674 C00042440 0 / 0
Q99700 Ataxin-2 Unclassified protein C00016743 C00042440 1 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00019674 C00042440 0 / 3
P03372 Estrogen receptor NR3A1 C00042440 1 / 1
P21728 D(1A) dopamine receptor Dopamine receptor C00042440 0 / 0
Q15788 Nuclear receptor coactivator 1 Enzyme C00042440 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00042440 2 / 2
P08246 Neutrophil elastase S1A C00042440 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00042440 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00042440 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00042440 0 / 0
P29466 Caspase-1 C14 C00042440 0 / 0
P17252 Protein kinase C alpha type Alpha C00042440 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00042440 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00042440 2 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00042440 0 / 0
P02545 Prelamin-A/C Unclassified protein C00042440 11 / 10
P10828 Thyroid hormone receptor beta NR1A2 C00042440 3 / 1
P00918 Carbonic anhydrase 2 Lyase C00042440 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00042440 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00042440 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00042440 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00042440 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00042440 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00042440 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00042440 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00042440 0 / 0
P27707 Deoxycytidine kinase Enzyme C00042440 0 / 0
P04183 Thymidine kinase, cytosolic Enzyme C00042440 0 / 1
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00042440 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00042440 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00042440 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00042440 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00042440 1 / 8
P14416 D(2) dopamine receptor Dopamine receptor C00042440 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00042440 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00042440 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00042440 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00042440 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00042440 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00042440 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00042440 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00042440 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00042440 1 / 0
P27708 CAD protein Enzyme C00019674 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00042440 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00042440 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00042440 4 / 1
P32320 Cytidine deaminase Enzyme C00042440 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00042440 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00042440 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00042440 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00042440 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00042440 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00042440 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00042440 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00042440 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00042440 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00042440 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00042440 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00042440 0 / 0
P08311 Cathepsin G S1A C00042440 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00042440 1 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00042440 0 / 0
P03956 Interstitial collagenase M10A C00042440 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00042440 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00042440 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00016743 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00042440 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00042440 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00042440 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00042440 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00042440 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00042440 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00042440 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00042440 0 / 0
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00042440 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00042440 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00042440 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00042440 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00042440 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00042440 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00042440 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00042440 0 / 0
Q9Y6Q9 Nuclear receptor coactivator 3 Enzyme C00042440 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00042440 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00042440 1 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00042440 1 / 0
P22303 Acetylcholinesterase Hydrolase C00042440 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00042440 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00042440 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00042440 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00042440 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00042440 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00042440 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00042440 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00042440 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00042440 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00042440 0 / 0
O00142 Thymidine kinase 2, mitochondrial Enzyme C00042440 1 / 1
P42345 Serine/threonine-protein kinase mTOR Enzyme C00042440 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00042440 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00042440 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00042440 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00042440 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00042440 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00042440 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00042440 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00042440 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00042440 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00042440 0 / 0
P40225 Thrombopoietin Unclassified protein C00042440 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00042440 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00016743 1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00016743 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00042440 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00042440 1 / 4

7 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
2993 GYPA, CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2 glycophorin A (MNS blood group) C00019674 C00042440
9154 SLC28A1, CNT1, HCNT1 solute carrier family 28 (concentrative nucleoside transporter), member 1 C00019674 C00042440
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00019674
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00019674
9153 SLC28A2, CNT2, HCNT2, HsT17153, SPNT1 solute carrier family 28 (concentrative nucleoside transporter), member 2 C00019674
2030 SLC29A1, ENT1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 C00019674
3177 SLC29A2, DER12, ENT2, HNP36 solute carrier family 29 (equilibrative nucleoside transporter), member 2 C00019674

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (62)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#609560 Mitochondrial dna depletion syndrome 2 (myopathic type); mtdps2 O00142
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (54)

KEGG name UniProt
H00469 Mitochondrial DNA depletion syndrome (MDS) O00142 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04183 (marker)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

16 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D007022 Hypotension C00042440
C00019674
D064420 Drug-Related Side Effects and Adverse Reactions C00019674
D000015 Abnormalities, Multiple C00019674
D000749 Anemia, Megaloblastic C00019674
D001919 Bradycardia C00019674
D002375 Catalepsy C00019674
D004342 Drug Hypersensitivity C00019674
D056486 Drug-Induced Liver Injury C00019674
D011041 Poisoning C00016743
D005234 Fatty Liver C00019674
D028361 Mitochondrial Diseases C00019674
C538525 Mitochondrial encephalopathy C00019674
D017240 Mitochondrial Myopathies C00019674
D010523 Peripheral Nervous System Diseases C00019674
D011565 Psoriasis C00019674
D019956 Stereotypic Movement Disorder C00019674