KEGG BRITE br08003 External link 512


Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00001382 External link 512 Se-methyl-L-selenocysteine
CHEMBL62382
CHEMBL1472699
C002979
16 / 8 / 6 37 / 6
C00034230 External link 512 Selenocysteine
CHEMBL109962
CHEMBL2111732
C00034232 External link 512 Se-Methylselenocysteine
CHEMBL62382
CHEMBL1472699
16 / 8 / 6
C00034233 External link 512 Se-Methylselenomethionine

Human Protein / Gene in interactions

16 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001382 C00034232 1 / 0
Q99700 Ataxin-2 Unclassified protein C00001382 C00034232 1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001382 C00034232 2 / 0
Q16773 Kynurenine--oxoglutarate transaminase 1 Enzyme C00001382 C00034232 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001382 C00034232 3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001382 C00034232 0 / 1
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00001382 C00034232 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00001382 C00034232 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001382 C00034232 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001382 C00034232 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00001382 C00034232 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00001382 C00034232 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001382 C00034232 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001382 C00034232 0 / 1
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001382 C00034232 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001382 C00034232 0 / 0

37 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00001382
54971 BANP, BEND1, SMAR1, SMARBP1 BTG3 associated nuclear protein C00001382
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00001382
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00001382
1066 CES1, ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1 carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) C00001382
5119 CHMP1A, CHMP1, PCH8, PCOLN3, PRSM1, VPS46-1, VPS46A charged multivesicular body protein 1A C00001382
1277 COL1A1, OI4 collagen, type I, alpha 1 C00001382
1278 COL1A2, OI4 collagen, type I, alpha 2 C00001382
1287 COL4A5, ASLN, ATS, CA54 collagen, type IV, alpha 5 C00001382
1291 COL6A1, OPLL collagen, type VI, alpha 1 C00001382
1294 COL7A1, EBD1, EBDCT, EBR1 collagen, type VII, alpha 1 C00001382
1577 CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) C00001382
4733 DRG1, NEDD3 developmentally regulated GTP binding protein 1 C00001382
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00001382
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00001382
2876 GPX1, GPXD, GSHPX1 glutathione peroxidase 1 (EC:1.11.1.9) C00001382
2879 GPX4, GPx-4, GSHPx-4, MCSP, PHGPx, snGPx, snPHGPx glutathione peroxidase 4 (EC:1.11.1.12) C00001382
2897 GRIK1, EAA3, EEA3, GLR5, GLUR5, GluK1 glutamate receptor, ionotropic, kainate 1 C00001382
2899 GRIK3, EAA5, GLR7, GLUR7, GluK3, GluR7a glutamate receptor, ionotropic, kainate 3 C00001382
3480 IGF1R, CD221, IGFIR, IGFR, JTK13 insulin-like growth factor 1 receptor (EC:2.7.10.1) C00001382
4288 MKI67, KIA, MIB-1 marker of proliferation Ki-67 C00001382
51734 MSRB1, SELR, SELX, SEPX1, SepR methionine sulfoxide reductase B1 (EC:1.8.4.-) C00001382
5033 P4HA1, P4HA prolyl 4-hydroxylase, alpha polypeptide I (EC:1.14.11.2) C00001382
5241 PGR, NR3C3, PR progesterone receptor C00001382
5865 RAB3B RAB3B, member RAS oncogene family C00001382
5867 RAB4A, HRES-1/RAB4, RAB4 RAB4A, member RAS oncogene family C00001382
949 SCARB1, CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1 scavenger receptor class B, member 1 C00001382
9403 SEP15 15 kDa selenoprotein C00001382
6414 SEPP1, SELP, SeP selenoprotein P, plasma, 1 C00001382
6415 SEPW1, selW selenoprotein W, 1 C00001382
6519 SLC3A1, ATR1, CSNU1, D2H, NBAT, RBAT solute carrier family 3 (amino acid transporter heavy chain), member 1 C00001382
8773 SNAP23, HsT17016, SNAP-23, SNAP23A, SNAP23B synaptosomal-associated protein, 23kDa C00001382
6272 SORT1, Gp95, LDLCQ6, NT3 sortilin 1 C00001382
393515 C00001382
8743 TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL tumor necrosis factor (ligand) superfamily, member 10 C00001382
54952 TRNAU1AP, PRO1902, RP4-669K10.4, SECP43, TRSPAP1 tRNA selenocysteine 1 associated protein 1 C00001382
7507 XPA, XP1, XPAC xeroderma pigmentosum, complementation group A C00001382

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (8)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (6)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

6 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001943 Breast Neoplasms C00001382
D056486 Drug-Induced Liver Injury C00001382
D006943 Hyperglycemia C00001382
D007003 Hypoglycemia C00001382
D007673 Kidney Cortex Necrosis C00001382
D008325 Mammary Neoplasms, Experimental C00001382