KCF-S cluster No. 2748 (4 metabolites)

Corresponding Phytochemical cluster No. 6

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (4)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	11
Magnoliophyta	5
rosids	3
Spermatophyta	1
Liliopsida	1

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Cumulative family count

class name	count
Asteraceae	5
Apiaceae	3
Lamiaceae	2
Schisandraceae	2
Plantaginaceae	1
Magnoliaceae	1
Bovidae	1
Saururaceae	1
Cupressaceae	1
Myrtaceae	1
Piperaceae	1
Acoraceae	1
Streptomycetaceae	1
Rutaceae	1
Ganodermataceae	1
Brassicaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Others	1

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metabolites link (2)

br08003 Category	KEGG ID	KNApSAcK ID
Others	C10428	C00002713
Others	C10428	C00029334

Metabolite list (4)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002713	Anethole	CHEMBL452630 CHEMBL1468832	C006578	6 / 21 / 49	16 / 13
C00002757	4-Methoxycinnamaldehyde / p-Methoxycinnamaldehyde	CHEMBL452173
C00018703	Tuberin / Tuberine	CHEMBL1967986
C00029334	(E)-Anethol / trans-Anethol / trans-1-(4-Methoxyphenyl)-1-propene	CHEMBL452630 CHEMBL1468832		6 / 21 / 49

Human Protein / Gene in interactions

6 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P04637	Cellular tumor antigen p53	Transcription Factor	C00002713 C00029334	7 / 37
P02545	Prelamin-A/C	Unclassified protein	C00002713 C00029334	11 / 10
P16473	Thyrotropin receptor	Glycohormone receptor	C00002713 C00029334	3 / 2
P00352	Retinal dehydrogenase 1	Enzyme	C00002713 C00029334	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002713 C00029334	0 / 1
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002713 C00029334	0 / 0

16 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00002713
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00002713
3551	IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10)	C00002713
5604	MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1	mitogen-activated protein kinase kinase 1 (EC:2.7.12.2)	C00002713
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00002713
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00002713
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00002713
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00002713
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00002713
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00002713
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00002713
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00002713
5328	PLAU, ATF, BDPLT5, QPD, UPA, URK, u-PA	plasminogen activator, urokinase (EC:3.4.21.73)	C00002713
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002713
7076	TIMP1, CLGI, EPA, EPO, HCI, TIMP	TIMP metallopeptidase inhibitor 1	C00002713
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00002713

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions