KCF-S cluster No. 32 (106 metabolites)

Corresponding Phytochemical cluster No. 51

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (106)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	84
rosids	37
eudicotyledons	11

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Cumulative family count

class name	count
Araliaceae	56
Plantaginaceae	21
Fabaceae	20
Cucurbitaceae	7
Ranunculaceae	7
Rubiaceae	6
Malvaceae	5
Molluginaceae	3
Rhamnaceae	3
Sapindaceae	2
Pittosporaceae	1
Caryophyllaceae	1

KEGG BRITE br08003

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Categories (3)

br08003 Category	# of metabolite
Protostanes	4
Others	5
Dammarenes	2

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metabolites link (11)

br08003 Category	KEGG ID	KNApSAcK ID
Protostanes	C08924	C00003500
Others	C08936	C00003510
Others	C08937	C00003511
Dammarenes	C08945	C00003519
Dammarenes	C08946	C00003520
Others	C08969	C00003543
Others	C08985	C00003555
Others	C08991	C00003561
Protostanes	C17798	C00035247
Protostanes	C17799	C00035248
Protostanes	C17797	C00050007

Metabolite list (106)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00003500	Astragaloside III
C00003510	Colubrin
C00003511	Colubrinoside
C00003519	Ginsenoside Rf	CHEMBL1773987	C055328		1 / 0
C00003520	Ginsenoside Rg1	CHEMBL501637 CHEMBL1977916	C035054		5 / 6
C00003543	Pittoside A
C00003555	Thalicoside A
C00003561	Ziziphin		C025127
C00024136	15alpha-Hydroxycimicidol-3-O-beta-xyloside		C067211
C00024137	Pseudo-ginsenoside F11	CHEMBL509047 CHEMBL1899126 CHEMBL1899642		3 / 0 / 0
C00029310	Ginsenoside F4 / (20E)-Ginsenoside F4 / (-)-(20E)-Ginsenoside F4
C00029439	20(R)-Ginsenoside Rg3	CHEMBL398412 CHEMBL1095008 CHEMBL1735785 CHEMBL2151041		2 / 0 / 0
C00029447	24(S)-Pseudoginsenoside F11 / 24(S)-Pseudo-ginsenoside F11	CHEMBL509047 CHEMBL1899126 CHEMBL1899642		3 / 0 / 0
C00029711	Aquilegioside G
C00029767	Bacopasaponin A
C00029768	Bacopasaponin B
C00029769	Bacopasaponin C	CHEMBL225246
C00029770	Bacopasaponin D
C00029771	Bacopasaponin E
C00029772	Bacopasaponin F / Bacopaside VIII
C00029773	Bacopasaponin G
C00029774	Bacopaside I	CHEMBL390537
C00029775	Bacopaside II
C00029776	Bacopaside III / (-)-Bacopaside III
C00029777	Bacopaside IV
C00029778	Bacopaside N1
C00029779	Bacopaside N2
C00029780	Bacopaside V
C00029781	Bacopaside X	CHEMBL225246
C00029782	Bacoside A1
C00029783	Bacoside A2
C00029784	Bacoside A3	CHEMBL447375	C087625
C00030254	Floralginsenoside A
C00030255	Floralginsenoside B
C00030256	Floralginsenoside C / (+)-Floralginsenoside C
C00030257	Floralginsenoside D
C00030258	Floralginsenoside E / (+)-Floralginsenoside E
C00030259	Floralginsenoside F / (+)-Floralginsenoside F
C00030265	Floralquinquenoside B
C00030266	Floralquinquenoside C / (-)-Floralquinquenoside C
C00030267	Floralquinquenoside D
C00030389	Ginsenoside F2	CHEMBL1095007		2 / 0 / 0
C00030390	Ginsenoside F3	CHEMBL1095004		2 / 0 / 0
C00030392	Ginsenoside Ia
C00030399	Panaxoside Rg2 / Ginsenoside Rg2	CHEMBL505747 CHEMBL1095005 CHEMBL1095006 CHEMBL1475728	C026474	5 / 0 / 0	7 / 2
C00030400	Ginsenoside Rg3	CHEMBL398412 CHEMBL1095008 CHEMBL1735785 CHEMBL2151041	C097367	2 / 0 / 0	5 / 2
C00030401	Ginsenoside Rg8 / (+)-Ginsenoside Rg8
C00030848	Notoginsenoside J / (+)-Notoginsenoside J
C00030856	Ginsenoside R2 / Notoginsenoside R2
C00031119	Quinquenoside L9
C00032291	Tarecilioside C / (+)-Tarecilioside C
C00032292	Tarecilioside D / (+)-Tarecilioside D
C00032293	Tarecilioside E / (+)-Tarecilioside E / 18-Deoxytarecilioside D
C00032294	Tarecilioside F / (+)-Tarecilioside F
C00032295	Tarecilioside G
C00032815	Ginsenoside F5 / Chikusetsusaponin L8	CHEMBL583152		2 / 0 / 0
C00032902	Depressoside C / (-)-Depressoside C
C00032903	Depressoside D / (-)-Depressoside D
C00032990	Ginsenoside Rg7
C00033153	Majoroside F2
C00033154	Majoroside F4
C00033446	Trojanoside A / (+)-Trojanoside A
C00033453	Trojanoside I
C00033654	Askendoside C
C00033875	Ginsenoside Rg5	CHEMBL400244
C00033876	Ginsenoside Rg6
C00033879	Ginsenoside Rk1 / (+)-Ginsenoside Rk1	CHEMBL251235
C00033884	Ginsenoside Rs3 / (+)-Ginsenoside Rs3
C00033885	Ginsenoside Rs4 / (+)-Ginsenoside Rs4
C00033886	Ginsenoside Rs5 / (+)-Ginsenoside Rs5
C00034215	Sapinmusaponin O
C00034216	Sapinmusaponin P / (-)-Sapinmusaponin P
C00035247	Astragaloside II
C00035248	Astragaloside IV	CHEMBL378140 CHEMBL1998472		1 / 4 / 2
C00035286	Cyclocanthoside E
C00035851	Kahiricoside V
C00037835	Spergulacin / (-)-Spergulacin
C00037836	Spergulacin A
C00037838	Spergulin B / (-)-Spergulin B
C00038575	Bacopaside VI / (-)-Bacopaside VI
C00040882	Astraverrucin IV / (+)-Peregrinoside I
C00040883	Astraverrucin V / (+)-Astraverrucin V
C00040884	Astraverrucin VI / (+)-Astraverrucin VI
C00041468	Cyclocanthoside D
C00043553	Gynoside A / (-)-Gynoside A
C00043554	Gynoside B / (+)-Gynoside B
C00043555	Gynoside C / (-)-Gynoside C
C00043556	Gynoside D / (+)-Gynoside D
C00043557	Gynoside E / (+)-Gynoside E
C00043560	Gypenoside LX
C00043562	Gypenoside LXXVII
C00044332	Succulentoside F
C00045233	Beesioside H / (+)-Beesioside H
C00045438	Vina-ginsenoside R1	CHEMBL509866 CHEMBL1869676
C00045439	Vina-ginsenoside R2	CHEMBL448234
C00045456	Yesanchinoside A / (+)-Yesanchinoside A
C00045459	Yesanchinoside D / (+)-Yesanchinoside D
C00046322	Polysciasoside A / (-)-Polysciasoside A
C00046364	Rubiarboside G
C00046501	Vina-ginsenoside R1	CHEMBL509866 CHEMBL1869676
C00046503	Vina-ginsenoside R2	CHEMBL448234
C00046504	Vina-ginsenoside R25 / (+)-Vina-ginsenoside R25	CHEMBL503328
C00046952	Thalicoside A1 / (+)-Thalicoside A1
C00046953	Thalicoside A2 / (+)-Thalicoside A2	CHEMBL446322
C00046954	Thalicoside A3 / (+)-Thalicoside A3
C00050007	Astragaloside I

Human Protein / Gene in interactions

8 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P11388	DNA topoisomerase 2-alpha	Isomerase	C00029439 C00030389 C00030390 C00030399 C00030400 C00032815	0 / 0
P11387	DNA topoisomerase 1	Isomerase	C00029439 C00030389 C00030390 C00030399 C00030400 C00032815	0 / 0
O75496	Geminin	Unclassified protein	C00024137 C00029447 C00030399	0 / 0
P14735	Insulin-degrading enzyme	Enzyme	C00024137 C00029447	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00024137 C00029447	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00030399	0 / 0
P14679	Tyrosinase	Oxidoreductase	C00035248	4 / 2
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00030399	0 / 0

17 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
3757	KCNH2, ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1	potassium voltage-gated channel, subfamily H (eag-related), member 2	C00003519 C00003520
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00003520
2932	GSK3B	glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)	C00030399
8431	NR0B2, SHP, SHP1	nuclear receptor subfamily 0, group B, member 2	C00030399
5105	PCK1, PEPCK-C, PEPCK1, PEPCKC	phosphoenolpyruvate carboxykinase 1 (soluble) (EC:4.1.1.32)	C00030399
10891	PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	C00030399
6794	STK11, LKB1, PJS, hLKB1	serine/threonine kinase 11 (EC:2.7.11.1)	C00030399
898	CCNE1, CCNE	cyclin E1	C00003520
92579	G6PC3, SCN4, UGRP	glucose 6 phosphatase, catalytic, 3 (EC:3.1.3.9)	C00030399
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00003520
200186	CRTC2, TORC-2, TORC2	CREB regulated transcription coactivator 2	C00030399
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00003520
367	AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM	androgen receptor	C00030400
332	BIRC5, API4, EPR-1	baculoviral IAP repeat containing 5	C00030400
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00030400
354	KLK3, APS, KLK2A1, PSA, hK3	kallikrein-related peptidase 3 (EC:3.4.21.77)	C00030400
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00030400

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions