KCF-S cluster No. 321 (21 metabolites)

Corresponding Phytochemical cluster No. 11

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (21)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

---

Cumulative plant class count

class name	count
Liliopsida	36

---

Cumulative family count

class name	count
Melanthiaceae	36

KEGG BRITE br08003

---

Categories (1)

br08003 Category	# of metabolite
Steroid alkaloids	3

---

metabolites link (3)

br08003 Category	KEGG ID	KNApSAcK ID
Steroid alkaloids	C10815	C00002256
Steroid alkaloids	C10816	C00002257
Steroid alkaloids	C06544	C00029202

Metabolite list (21)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002256	Protoveratrine A	CHEMBL1565588 CHEMBL2105769		8 / 5 / 5
C00002257	Protoveratrine B	CHEMBL1398134 CHEMBL2165398
C00024017	(+)-Maackinine
C00027693	15-Veratroylgermine / Germine 15-(3,4-dimethoxybenzoate)
C00027733	3,15-Diangeloylgermine
C00027739	3-Acetyl-15-veratroylgermine
C00028295	Germanitrine
C00028296	Germbudine
C00028297	Germerine		C427629
C00028299	Germinaline
C00028301	Germinine
C00028302	Germitetrine
C00028535	Maackinine
C00028667	Neogermbudine		C052980
C00028670	Neojerminalanine / Neojerminalanine / (-)-Neojerminalanine
C00029052	Stenophylline A
C00029176	Vanilloylzygadenine / 3-Vanilloylzygadenine
C00029183	Verabenzoamine
C00029202	Veratrine	CHEMBL439496 CHEMBL451227 CHEMBL1363612 CHEMBL1710967	D014701	11 / 6 / 8	0 / 1
C00029204	Veratroylzygadenine
C00029219	Verussurine / (+)-Verussurine

Human Protein / Gene in interactions

13 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002256 C00029202	1 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00002256 C00029202	3 / 2
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002256 C00029202	0 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002256 C00029202	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002256 C00029202	1 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002256 C00029202	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00029202	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00002256	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00029202	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00002256	0 / 0
P31939	Bifunctional purine biosynthesis protein PURH	Enzyme	C00029202	1 / 1
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00029202	0 / 0
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00029202	0 / 3

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions