KCF-S cluster No. 345 (19 metabolites)

Corresponding Phytochemical cluster No. 4

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (19)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Magnoliophyta	47
eudicotyledons	38
rosids	7
asterids	1
Liliopsida	1

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Cumulative family count

class name	count
Annonaceae	27
Lauraceae	17
Papaveraceae	16
Menispermaceae	10
Berberidaceae	8
Ranunculaceae	3
Celastraceae	2
Rhamnaceae	2
Euphorbiaceae	2
Hernandiaceae	2
Loganiaceae	1
Siparunaceae	1
Nelumbonaceae	1
Fabaceae	1
Colchicaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Isoquinoline alkaloids	3

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metabolites link (4)

br08003 Category	KEGG ID	KNApSAcK ID
Isoquinoline alkaloids	C09555	C00001875
Isoquinoline alkaloids	C09558	C00001876
Isoquinoline alkaloids	C17592	C00028453
Isoquinoline alkaloids	C09558	C00028454

Metabolite list (19)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001810	Armepavine / (-)-Armepavine / (R)-(-)-Armepavine	CHEMBL451722 CHEMBL1186477 CHEMBL1186510		7 / 5 / 3
C00001875	Tritopin / Tritopine / Laudanidine / (-)-Laudanidine	CHEMBL251625 CHEMBL1425007		2 / 0 / 0
C00001876	Laudanosine / L-Laudanosine / O-Methylcodamine / L-(+)-Laudanosine	CHEMBL1407 CHEMBL519894 CHEMBL1613	C001522	18 / 26 / 21	0 / 1
C00001910	Reticuline / (+)-Reticuline	CHEMBL235212 CHEMBL401501 CHEMBL464734	C003298	1 / 0 / 0
C00025654	Codamine / (+)-Codamine / L-(+)-Codamine / (S)-(+)-Codamine	CHEMBL251624
C00025666	(S)-Laudanine / (+)-Laudanidine / L-(+)-Laudanidine	CHEMBL251625 CHEMBL1425007		2 / 0 / 0
C00026017	Protosinomenine / (S)-Protosinomenine
C00026113	Canadaline / (+)-Canadaline	CHEMBL1968299
C00027523	Bernumicine / (+)-Bernumicine / (R)-Bernumicine
C00027524	Bernumine / (+)-Bernumine
C00027866	Anicanine
C00028078	Colchiethine
C00028453	Laudanine	CHEMBL251625 CHEMBL1425007		2 / 0 / 0
C00028454	Laudanosine	CHEMBL1407 CHEMBL519894 CHEMBL1613		18 / 26 / 21
C00028871	Pseudolaudanine
C00028938	Roefractine
C00034987	(+)-Parvinine	CHEMBL452500
C00040992	Heterocarpine
C00046196	N-Demethylphyllocryptine

Human Protein / Gene in interactions

23 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00001810 C00001875 C00001876 C00025666 C00028453 C00028454	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00001810 C00001876 C00028454	3 / 3
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001810 C00001876 C00028454	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00001810 C00001876 C00028454	0 / 0
O75496	Geminin	Unclassified protein	C00001875 C00025666 C00028453	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00001876 C00028454	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001876 C00028454	1 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00001876 C00028454	2 / 2
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00001876 C00028454	7 / 3
P83916	Chromobox protein homolog 1	Unclassified protein	C00001876 C00028454	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00001876 C00028454	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00001876 C00028454	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001876 C00028454	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001876 C00028454	0 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001876 C00028454	0 / 1
P02545	Prelamin-A/C	Unclassified protein	C00001876 C00028454	11 / 10
Q9UNA4	DNA polymerase iota	Enzyme	C00001876 C00028454	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001876 C00028454	1 / 1
P22303	Acetylcholinesterase	Hydrolase	C00001876 C00028454	1 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00001810	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00001910	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00001810	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00001810	2 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions