KEGG BRITE br08003 External link 512


Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00001183 External link 512 Fumaric acid
CHEMBL503160
CHEMBL539648
C032005
17 / 14 / 46 0 / 1
C00007417 External link 512 Maleate
CHEMBL503160
CHEMBL539648
17 / 14 / 46
C00033849 External link 512 Fumarate
CHEMBL503160
CHEMBL539648
17 / 14 / 46

Human Protein / Gene in interactions

17 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor C00001183 C00007417 C00033849 7 / 37
Q16798 NADP-dependent malic enzyme, mitochondrial Enzyme C00001183 C00007417 C00033849 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00001183 C00007417 C00033849 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00001183 C00007417 C00033849 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001183 C00007417 C00033849 3 / 2
P00918 Carbonic anhydrase 2 Lyase C00001183 C00007417 C00033849 1 / 2
Q9GZT9 Egl nine homolog 1 Enzyme C00001183 C00007417 C00033849 1 / 1
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00001183 C00007417 C00033849 0 / 0
O75496 Geminin Unclassified protein C00001183 C00007417 C00033849 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00001183 C00007417 C00033849 0 / 0
P11308 Transcriptional regulator ERG Unclassified protein C00001183 C00007417 C00033849 1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00001183 C00007417 C00033849 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001183 C00007417 C00033849 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001183 C00007417 C00033849 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001183 C00007417 C00033849 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001183 C00007417 C00033849 0 / 0
Q9C0B1 Alpha-ketoglutarate-dependent dioxygenase FTO Unclassified protein C00001183 C00007417 C00033849 1 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (14)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#609820 Erythrocytosis, familial, 3; ecyt3 Q9GZT9
#133239 Esophageal cancer P04637
#612219 Ewing sarcoma; es P11308
#612938 Growth retardation, developmental delay, coarse facies, and early death; gdfd Q9C0B1
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260500 Papilloma of choroid plexus; cpp P04637
#275355 Squamous cell carcinoma, head and neck; hnscc P04637

KEGG DISEASE (46)

KEGG name UniProt
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00409 Type II diabetes mellitus Q9C0B1 (related)
H00926 Growth retardation, developmental delay, coarse facies, and early death Q9C0B1 (related)
H00236 Congenital polycythemia Q9GZT9 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002471 Cell Transformation, Neoplastic C00001183