KCF-S cluster No. 3820 (1 metabolites)

Corresponding Phytochemical cluster No. 12


Plant Species


Cumulative plant class count

class name count

Cumulative family count

class name count
Pseudomonadaceae 1

KEGG BRITE br08003 External link 512


Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00018807 External link 512 Tabloid
/ NSC 752
/ Tioguanin
/ NSC 76504
/ Tioguanine
/ Thioguanine
/ 6-Thioguanine
/ 6-Mercaptoguanine
CHEMBL727
D013866
111 / 62 / 66 6 / 29

Human Protein / Gene in interactions

111 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00018807 1 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00018807 7 / 37
Q16637 Survival motor neuron protein Unclassified protein C00018807 4 / 1
Q99700 Ataxin-2 Unclassified protein C00018807 1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00018807 2 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00018807 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00018807 0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00018807 2 / 2
P08246 Neutrophil elastase S1A C00018807 2 / 1
P33765 Adenosine receptor A3 Adenosine receptor C00018807 0 / 0
P00492 Hypoxanthine-guanine phosphoribosyltransferase Enzyme C00018807 2 / 1
Q16539 Mitogen-activated protein kinase 14 p38 C00018807 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00018807 0 / 0
P29466 Caspase-1 C14 C00018807 0 / 0
P17252 Protein kinase C alpha type Alpha C00018807 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00018807 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00018807 2 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00018807 1 / 1
P00918 Carbonic anhydrase 2 Lyase C00018807 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00018807 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00018807 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00018807 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00018807 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00018807 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00018807 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00018807 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00018807 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00018807 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00018807 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00018807 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00018807 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00018807 1 / 8
P14416 D(2) dopamine receptor Dopamine receptor C00018807 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00018807 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00018807 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00018807 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00018807 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00018807 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00018807 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00018807 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00018807 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00018807 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00018807 0 / 0
P68871 Hemoglobin subunit beta Secreted protein C00018807 4 / 4
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00018807 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00018807 2 / 0
O75496 Geminin Unclassified protein C00018807 0 / 0
O15439 Multidrug resistance-associated protein 4 Unclassified protein C00018807 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00018807 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00018807 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00018807 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00018807 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00018807 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00018807 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00018807 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00018807 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00018807 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00018807 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00018807 1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00018807 0 / 0
P08311 Cathepsin G S1A C00018807 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00018807 1 / 0
P03956 Interstitial collagenase M10A C00018807 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00018807 0 / 0
P11308 Transcriptional regulator ERG Unclassified protein C00018807 1 / 2
P04150 Glucocorticoid receptor NR3C1 C00018807 0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00018807 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00018807 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00018807 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00018807 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00018807 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00018807 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00018807 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00018807 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00018807 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00018807 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00018807 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00018807 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00018807 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00018807 0 / 0
Q13153 Serine/threonine-protein kinase PAK 1 STE serine/threonine protein kinase PAKA subfamily C00018807 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00018807 2 / 2
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00018807 0 / 0
P03372 Estrogen receptor NR3A1 C00018807 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00018807 1 / 0
P22303 Acetylcholinesterase Hydrolase C00018807 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00018807 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00018807 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00018807 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00018807 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00018807 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00018807 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00018807 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00018807 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00018807 0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00018807 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00018807 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00018807 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00018807 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00018807 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00018807 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00018807 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00018807 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00018807 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00018807 0 / 0
Q07817 Bcl-2-like protein 1 Other cytosolic protein C00018807 0 / 0
P10415 Apoptosis regulator Bcl-2 Other cytosolic protein C00018807 0 / 7
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00018807 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00018807 1 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00018807 0 / 0
Q06710 Paired box protein Pax-8 Unclassified protein C00018807 1 / 2

6 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
10257 ABCC4, EST170205, MOAT-B, MOATB, MRP4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 C00018807
10057 ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 C00018807
329 BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 baculoviral IAP repeat containing 2 C00018807
3615 IMPDH2, IMPD2, IMPDH-II IMP (inosine 5'-monophosphate) dehydrogenase 2 (EC:1.1.1.205) C00018807
4436 MSH2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2 mutS homolog 2 C00018807
100506658 OCLN, BLCPMG occludin (EC:2.1.1.67) C00018807

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (62)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#613985 Beta-thalassemia P68871
#603902 Beta-thalassemia, dominant inclusion body type P68871
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#114500 Colorectal cancer; crc P84022
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#612219 Ewing sarcoma; es P11308
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
#140700 Heinz body anemias P68871
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#218700 Hypothyroidism, congenital, nongoitrous, 2; chng2 Q06710
#603932 Intervertebral disc disease; idd P14780
#300323 Kelley-seegmiller syndrome P00492
#300322 Lesch-nyhan syndrome; lns P00492
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#603903 Sickle cell anemia P68871
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (66)

KEGG name UniProt
H00194 Lesch-Nyhan syndrome P00492 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
P10415 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
P68871 (marker)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
P10415 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
P10415 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
P10415 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
P10415 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
P68871 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
Q06710 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
P10415 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00054 Nasopharyngeal cancer P10415 (related)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00192 Xanthinuria P47989 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00228 Thalassemia P68871 (related)
H00229 Sickle cell anemia (SCA) P68871 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) Q06710 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

29 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000740 Anemia C00018807
D001201 Ascites C00018807
D006502 Budd-Chiari Syndrome C00018807
D002526 Cerebellar Diseases C00018807
D003424 Crohn Disease C00018807
D003967 Diarrhea C00018807
D056486 Drug-Induced Liver Injury C00018807
D004932 Esophageal and Gastric Varices C00018807
D005355 Fibrosis C00018807
D020518 Focal Nodular Hyperplasia C00018807
D006471 Gastrointestinal Hemorrhage C00018807
D006331 Heart Diseases C00018807
D006504 Hepatic Veno-Occlusive Disease C00018807
D006965 Hyperplasia C00018807
D006975 Hypertension, Portal C00018807
D015212 Inflammatory Bowel Diseases C00018807
D007938 Leukemia C00018807
D007945 Leukemia, Lymphoid C00018807
D007951 Leukemia, Myeloid C00018807
D015470 Leukemia, Myeloid, Acute C00018807
D015473 Leukemia, Promyelocytic, Acute C00018807
D010198 Pancytopenia C00018807
D010382 Peliosis Hepatis C00018807
D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma C00018807
D054218 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma C00018807
D011565 Psoriasis C00018807
D013163 Splenomegaly C00018807
D013921 Thrombocytopenia C00018807
D014202 Tremor C00018807