Plant Species


Cumulative plant class count

class name count

Cumulative family count

class name count
Micromonosporaceae 2
Streptomycetaceae 1

KEGG BRITE br08003 External link 512


Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00018638 External link 512 Streptonigrone
C045696
C00026396 External link 512 7-(1-Methyl-2-oxopropyl)streptonigrin
CHEMBL447860
C00026485 External link 512 SN
/ STP
/ Nigrin
/ Streptonigrin
/ Streptonigran
/ Rufocromomycin
CHEMBL11417
D013308
36 / 45 / 37 1 / 1

Human Protein / Gene in interactions

36 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q16637 Survival motor neuron protein Unclassified protein C00026485 4 / 1
Q99700 Ataxin-2 Unclassified protein C00026485 1 / 1
P06746 DNA polymerase beta Enzyme C00026485 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00026485 0 / 0
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00026485 1 / 4
P02545 Prelamin-A/C Unclassified protein C00026485 11 / 10
P54132 Bloom syndrome protein Enzyme C00026485 1 / 2
P51570 Galactokinase Enzyme C00026485 1 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00026485 1 / 0
P11473 Vitamin D3 receptor NR1I1 C00026485 2 / 3
P39748 Flap endonuclease 1 Enzyme C00026485 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00026485 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00026485 2 / 0
O75496 Geminin Unclassified protein C00026485 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00026485 0 / 0
O00519 Fatty-acid amide hydrolase 1 Enzyme C00026485 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00026485 7 / 3
Q9Y253 DNA polymerase eta Enzyme C00026485 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00026485 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00026485 1 / 2
P28482 Mitogen-activated protein kinase 1 Erk C00026485 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00026485 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00026485 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00026485 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00026485 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00026485 4 / 3
Q9UM07 Protein-arginine deiminase type-4 Enzyme C00026485 1 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00026485 0 / 0
P34949 Mannose-6-phosphate isomerase Enzyme C00026485 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00026485 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00026485 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00026485 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00026485 1 / 0
O00255 Menin Unclassified protein C00026485 2 / 5
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00026485 2 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein C00026485 1 / 1

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1728 NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) C00026485

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (45)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#208900 Ataxia-telangiectasia; at Q13315
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
Q14191
#602579 Congenital disorder of glycosylation, type ib; cdg1b P34949
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#230200 Galactokinase deficiency P51570
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257220 Niemann-pick disease, type c1; npc1 O15118
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#180300 Rheumatoid arthritis; ra Q9UM07
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (37)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00118 Congenital disorders of glycosylation (CDG) type I P34949 (related)
H00070 Galactosemia P51570 (related)
H00094 DNA repair defects P54132 (related)
Q13315 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D005909 Glioblastoma C00026485