KCF-S cluster No. 466 (17 metabolites)

Corresponding Phytochemical cluster No. 25

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (17)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	27
rosids	19
eudicotyledons	1

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Cumulative family count

class name	count
Rutaceae	18
Apiaceae	18
Asteraceae	9
Picrodendraceae	1
Plumbaginaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Coumarins	1

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metabolites link (1)

br08003 Category	KEGG ID	KNApSAcK ID
Coumarins	C09280	C00002488

Metabolite list (17)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00000577	Gerberacoumarin
C00002488	Osthol / Osthole	CHEMBL52229	C046627	12 / 6 / 5	7 / 4
C00019782	Anisocoumarin B
C00019809	Capensin	CHEMBL1327256		18 / 11 / 10
C00019847	7-(3,3-Dimethylallyloxy)-6-hydroxy-5-methoxycoumarin
C00019871	4-[5-Formyl-3-methyl-pent-2E,4E-dien-1-yl]-5-methylcoumarin
C00020012	7-Methoxy-6-[(3-methyl-2-butenyl)oxy]coumarin
C00022705	7-Isopentenyloxycoumarin	CHEMBL156692		9 / 1 / 2
C00033197	Micromarin F
C00034856	Haplopinol
C00034885	Prenyletin	CHEMBL607536		9 / 2 / 3
C00036085	Cedrecoumarin B / Microfolicoumarin
C00036889	Cedrelopsin
C00037581	O-Methylcedrelopsin	CHEMBL1338393		2 / 0 / 0
C00037864	Suberosin	CHEMBL1928409		1 / 0 / 0
C00044069	7-(3-Methyl-2-butenyloxy)-6-methoxycoumarin	CHEMBL594886
C00045592	7-Methoxy-5-prenyloxy-coumarin	CHEMBL513279		1 / 1 / 0

Human Protein / Gene in interactions

35 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00019809 C00022705 C00034885 C00037581	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00002488 C00022705 C00034885	0 / 0
P56817	Beta-secretase 1	A1A	C00002488 C00022705 C00037864	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002488 C00019809 C00034885	0 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00002488 C00022705 C00037581	0 / 0
P55210	Caspase-7	C14	C00019809 C00034885	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00019809 C00022705	0 / 0
P29466	Caspase-1	C14	C00019809 C00034885	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00019809 C00022705	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00002488 C00019809	0 / 0
O75496	Geminin	Unclassified protein	C00002488 C00019809	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00019809	1 / 0
P11308	Transcriptional regulator ERG	Unclassified protein	C00022705	1 / 2
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00002488	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00002488	0 / 0
Q96RI1	Bile acid receptor	NR1H4	C00022705	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00034885	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00019809	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00019809	3 / 3
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00034885	2 / 2
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00019809	0 / 1
P22303	Acetylcholinesterase	Hydrolase	C00045592	1 / 0
P04406	Glyceraldehyde-3-phosphate dehydrogenase	Enzyme	C00002488	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00019809	1 / 1
P04062	Glucosylceramidase	Enzyme	C00002488	6 / 4
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00002488	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00019809	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00034885	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00019809	4 / 3
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00022705	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00034885	0 / 0
O14980	Exportin-1	Unclassified protein	C00002488	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00019809	1 / 1
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00019809	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00019809	1 / 1

7 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
2180	ACSL1, ACS1, FACL1, FACL2, LACS, LACS1, LACS2	acyl-CoA synthetase long-chain family member 1 (EC:6.2.1.3)	C00002488
1374	CPT1A, CPT1, CPT1-L, L-CPT1	carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21)	C00002488
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00002488
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00002488
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00002488
5465	PPARA, NR1C1, PPAR, PPARalpha, hPPAR	peroxisome proliferator-activated receptor alpha	C00002488
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002488

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions