KCF-S cluster No. 4779 (2 metabolites)
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| asterids | 6 |
| rosids | 2 |
Cumulative family count
| class name | count |
|---|---|
| Solanaceae | 6 |
| Cucurbitaceae | 2 |
KEGG BRITE br08003
Categories (0)
| br08003 Category | # of metabolite |
|---|
metabolites link (0)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
Metabolite list (2)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00040805
|
25-Hydroxyvitamin D3
|
CHEMBL15596
CHEMBL1040 CHEMBL80554 CHEMBL1222 CHEMBL1599212 |
D002112
|
7 / 12 / 7 | 3 / 5 |
|
|
C00041217
|
Vitamin D3
/ Cholecalciferol |
CHEMBL1042
CHEMBL432780 CHEMBL1236645 CHEMBL1354424 CHEMBL1365250 CHEMBL1456744 CHEMBL1475972 CHEMBL1949934 CHEMBL1966661 |
D002762
|
117 / 75 / 80 | 47 / 35 |
|
Human Protein / Gene in interactions
119 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q16637 | Survival motor neuron protein | Unclassified protein | C00040805 C00041217 | 4 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00040805 C00041217 | 4 / 3 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00040805 C00041217 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00040805 C00041217 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00040805 C00041217 | 2 / 3 |
| P03372 | Estrogen receptor | NR3A1 | C00041217 | 1 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00041217 | 0 / 3 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00041217 | 2 / 2 |
| P08246 | Neutrophil elastase | S1A | C00041217 | 2 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00041217 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00041217 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00041217 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00041217 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00041217 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00041217 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00041217 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00041217 | 2 / 2 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00041217 | 3 / 1 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00041217 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00041217 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00041217 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00041217 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00041217 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00041217 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00041217 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00041217 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00041217 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00041217 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00041217 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00041217 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00041217 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00041217 | 0 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00041217 | 1 / 8 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00040805 | 2 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00041217 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00041217 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00041217 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00041217 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00041217 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00041217 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00041217 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00041217 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00041217 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00041217 | 1 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00041217 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00041217 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00041217 | 1 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00041217 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00041217 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00041217 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00041217 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00041217 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00041217 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00041217 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00041217 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00041217 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00041217 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00041217 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00041217 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00041217 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00041217 | 0 / 0 |
| P07711 | Cathepsin L1 | C1A | C00040805 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00041217 | 1 / 0 |
| P03956 | Interstitial collagenase | M10A | C00041217 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00041217 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00041217 | 7 / 37 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00041217 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00041217 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00041217 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00041217 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00041217 | 2 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00041217 | 5 / 3 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00041217 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00041217 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00041217 | 0 / 0 |
| P30304 | M-phase inducer phosphatase 1 | Ser_Thr_Tyr | C00041217 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00041217 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00041217 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00041217 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00041217 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00041217 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00041217 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00041217 | 2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00041217 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00041217 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00041217 | 2 / 2 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00041217 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00041217 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00041217 | 0 / 0 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00041217 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00041217 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00041217 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00041217 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00041217 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00041217 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00041217 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00041217 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00041217 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00041217 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00041217 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00041217 | 0 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00041217 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00041217 | 5 / 1 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00041217 | 3 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00041217 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00041217 | 3 / 4 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00041217 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00041217 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00041217 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00041217 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00041217 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00041217 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00041217 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00041217 | 0 / 0 |
| Q99835 | Smoothened homolog | Smoothened receptor (frizzled family GPCR) | C00041217 | 0 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00041217 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00041217 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00041217 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00041217 | 1 / 2 |
48 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1591 | CYP24A1, CP24, CYP24, HCAI, P450-CC24 | cytochrome P450, family 24, subfamily A, polypeptide 1 (EC:1.14.13.126) |
C00040805
C00041217
|
| 7421 | VDR, NR1I1 | vitamin D (1,25- dihydroxyvitamin D3) receptor |
C00040805
C00041217
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00041217
|
| 10257 | ABCC4, EST170205, MOAT-B, MOATB, MRP4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 |
C00041217
|
| 572 | BAD, BBC2, BCL2L8 | BCL2-associated agonist of cell death |
C00041217
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00041217
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00041217
|
| 8678 | BECN1, ATG6, VPS30, beclin1 | beclin 1, autophagy related |
C00041217
|
| 632 | BGLAP, BGP, OC, OCN | bone gamma-carboxyglutamate (gla) protein |
C00041217
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00041217
|
| 898 | CCNE1, CCNE | cyclin E1 |
C00041217
|
| 929 | CD14 | CD14 molecule |
C00041217
|
| 978 | CDA, CDD | cytidine deaminase (EC:3.5.4.5) |
C00041217
|
| 1017 | CDK2, p33(CDK2) | cyclin-dependent kinase 2 (EC:2.7.11.22) |
C00041217
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00041217
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00041217
|
| 1032 | CDKN2D, INK4D, p19, p19-INK4D | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) |
C00041217
|
| 1555 | CYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450 | cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) |
C00041217
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00041217
|
| 1565 | CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 | cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) |
C00041217
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00041217
|
| 1577 | CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3 | cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) |
C00041217
|
| 3458 | IFNG, IFG, IFI | interferon, gamma |
C00041217
|
| 3586 | IL10, CSIF, GVHDS, IL-10, IL10A, TGIF | interleukin 10 |
C00041217
|
| 1594 | CYP27B1, CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR | cytochrome P450, family 27, subfamily B, polypeptide 1 (EC:1.14.13.13) |
C00040805
|
| 3684 | ITGAM, CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6 | integrin, alpha M (complement component 3 receptor 3 subunit) |
C00041217
|
| 3687 | ITGAX, CD11C, SLEB6 | integrin, alpha X (complement component 3 receptor 4 subunit) |
C00041217
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00041217
|
| 2475 | MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1 | mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) |
C00041217
|
| 4538 | ND4, MTND4, MT-ND4 | NADH dehydrogenase, subunit 4 (complex I) |
C00041217
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00041217
|
| 5289 | PIK3C3, VPS34, hVps34 | phosphatidylinositol 3-kinase, catalytic subunit type 3 (EC:2.7.1.137) |
C00041217
|
| 5371 | PML, MYL, PP8675, RNF71, TRIM19 | promyelocytic leukemia |
C00041217
|
| 5741 | PTH, PTH1 | parathyroid hormone |
C00041217
|
| 5829 | PXN | paxillin |
C00041217
|
| 5894 | RAF1, CRAF, NS5, Raf-1, c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) |
C00041217
|
| 5914 | RARA, NR1B1, RAR | retinoic acid receptor, alpha |
C00041217
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00041217
|
| 6198 | RPS6KB1, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70_S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha | ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1) |
C00041217
|
| 860 | RUNX2, AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA | runt-related transcription factor 2 |
C00041217
|
| 6678 | SPARC, ON | secreted protein, acidic, cysteine-rich (osteonectin) |
C00041217
|
| 6696 | SPP1, BNSP, BSPI, ETA-1, OPN | secreted phosphoprotein 1 |
C00041217
|
| 6901 | TAZ, BTHS, CMD3A, EFE, EFE2, G4.5, LVNCX, Taz1 | tafazzin |
C00041217
|
| 7040 | TGFB1, CED, DPD1, LAP, TGFB, TGFbeta | transforming growth factor, beta 1 |
C00041217
|
| 4982 | TNFRSF11B, OCIF, OPG, TR1 | tumor necrosis factor receptor superfamily, member 11b |
C00041217
|
| 8600 | TNFSF11, CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf | tumor necrosis factor (ligand) superfamily, member 11 |
C00041217
|
| 10628 | TXNIP, EST01027, HHCPA78, THIF, VDUP1 | thioredoxin interacting protein |
C00041217
|
| 7431 | VIM, CTRCT30 | vimentin |
C00041217
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (77)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| %606641 | Body mass index; bmi |
P37231
|
| #300615 | Brunner syndrome |
P21397
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
P04626
P37231 |
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 P04637 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
P37231 |
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (80)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) P04637 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
P04637 (related) P04637 (marker) |
| H00027 | Ovarian cancer |
P04626
(related)
P04637 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P04637 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P04637 (related) P35354 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P14780 (related) P35354 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
Q99835 (related) |
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
Q99714 (related) |
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
37 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D006934 | Hypercalcemia |
C00040805
C00041217 |
| D011471 | Prostatic Neoplasms |
C00040805
C00041217 |
| D010018 | Osteomalacia |
C00040805
C00041217 |
| D006130 | Growth Disorders |
C00041217
|
| D012080 | Renal Osteodystrophy |
C00040805
|
| D058186 | Acute Kidney Injury |
C00041217
|
| D000307 | Adrenal Gland Diseases |
C00041217
|
| D001018 | Aortic Diseases |
C00041217
|
| D001161 | Arteriosclerosis |
C00041217
|
| D050197 | Atherosclerosis |
C00041217
|
| D001327 | Autoimmune Diseases |
C00041217
|
| D002114 | Calcinosis |
C00041217
|
| D006332 | Cardiomegaly |
C00041217
|
| D015362 | Child Nutrition Disorders |
C00041217
|
| D003324 | Coronary Artery Disease |
C00041217
|
| D004342 | Drug Hypersensitivity |
C00041217
|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00041217
|
| D005767 | Gastrointestinal Diseases |
C00041217
|
| D009135 | Muscular Diseases |
C00040805
|
| D053565 | Hypercalciuria |
C00041217
|
| D054559 | Hyperphosphatemia |
C00041217
|
| D006965 | Hyperplasia |
C00041217
|
| D006973 | Hypertension |
C00041217
|
| D006996 | Hypocalcemia |
C00041217
|
| D020347 | Lithiasis |
C00041217
|
| D008325 | Mammary Neoplasms, Experimental |
C00041217
|
| D009120 | Muscle Cramp |
C00041217
|
| D009123 | Muscle Hypotonia |
C00041217
|
| D010673 | Pheochromocytoma |
C00041217
|
| D017285 | Polymyositis |
C00041217
|
| D051437 | Renal Insufficiency |
C00041217
|
| D012279 | Rickets |
C00041217
|
| D013971 | THYROTOXICOSIS |
C00041217
|
| D061205 | Vascular Calcification |
C00041217
|
| D014652 | Vascular Diseases |
C00041217
|
| D014808 | Vitamin D Deficiency |
C00041217
|
| D015431 | Weight Loss |
C00041217
|