KCF-S cluster No. 487 (15 metabolites)

Corresponding Phytochemical cluster No. 51

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (15)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	17

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Cumulative family count

class name	count
Meliaceae	17

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Limonoids	1

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metabolites link (1)

br08003 Category	KEGG ID	KNApSAcK ID
Limonoids	C11047	C00003698

Metabolite list (15)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00003698	Azadirachtin A	CHEMBL509309 CHEMBL506084 CHEMBL1557791	C010329	3 / 0 / 1	20 / 3
C00032575	1-(2-methylpropanoyl)-3-acetyl-11-methoxymeliacarpinin / (-)-1-(2-methylpropanoyl)-3-acetyl-11-methoxymeliacarpinin
C00033188	Meliacarpinin D / (-)-Meliacarpinin D
C00039740	Meliacarpinin A
C00039741	Meliacarpinin B / (-)-Meliacarpinin B
C00040753	1,3-Dicinnamoyl-11-hydroxymeliacarpin / (+)-1,3-Dicinnamoyl-11-hydroxymeliacarpin
C00040781	1-Cinnamoyl-3-acetyl-11-hydroxymeliacarpin / (+)-1-Cinnamoyl-3-acetyl-11-hydroxymeliacarpin
C00040782	1-Cinnamoyl-3-methacrylyl-11-hydroxymeliacarpin
C00042041	11alpha-Azadirachtin H	CHEMBL504820
C00042042	11-epi-Azadirachtin D / (-)-11-epi-Azadirachtin D
C00042264	Azadirachtin M / (-)-Azadirachtin M
C00042265	Azadirachtin O / (-)-Azadirachtin O	CHEMBL526884
C00042266	Azadirachtin P / (-)-Azadirachtin P	CHEMBL510520
C00042267	Azadirachtin Q / (-)-Azadirachtin Q	CHEMBL502955
C00049545	Azadirachtin N

Human Protein / Gene in interactions

3 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q96RI1	Bile acid receptor	NR1H4	C00003698	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00003698	0 / 1
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00003698	0 / 0

20 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
317	APAF1, APAF-1, CED4	apoptotic peptidase activating factor 1	C00003698
572	BAD, BBC2, BCL2L8	BCL2-associated agonist of cell death	C00003698
581	BAX, BCL2L4	BCL2-associated X protein	C00003698
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00003698
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00003698
637	BID, FP497	BH3 interacting domain death agonist	C00003698
332	BIRC5, API4, EPR-1	baculoviral IAP repeat containing 5	C00003698
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00003698
839	CASP6, MCH2	caspase 6, apoptosis-related cysteine peptidase (EC:3.4.22.59)	C00003698
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00003698
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00003698
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00003698
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00003698
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00003698
3551	IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10)	C00003698
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00003698
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00003698
5111	PCNA	proliferating cell nuclear antigen	C00003698
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00003698
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00003698

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions