PCIDB

KCF-S cluster No. 5064 (2 metabolites)

class name	count
rosids	2

class name	count
Brassicaceae	2

br08003 Category	# of metabolite

br08003 Category	KEGG ID	KNApSAcK ID

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00007388	L-Galactono-1,4-lactone	CHEMBL509311 CHEMBL466882 CHEMBL610071 CHEMBL1328484		10 / 17 / 16
C00007416	L-Gluconolactone / L-Glucono-1,5-lactone	CHEMBL1200829		2 / 17 / 14

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P02545	Prelamin-A/C	Unclassified protein	C00007388 C00007416	11 / 10
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00007388	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00007388	1 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00007388	3 / 1
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00007388	0 / 1
P04062	Glucosylceramidase	Enzyme	C00007416	6 / 4
O00462	Beta-mannosidase	Enzyme	C00007388	1 / 2
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00007388	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00007388	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00007388	0 / 1
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00007388	0 / 0

OMIM	preferred title	UniProt
#115200	Cardiomyopathy, dilated, 1a; cmd1a	P02545
#212112	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	P02545
#605588	Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1	P02545
#609535	Drug metabolism, poor, cyp2c19-related	P33261
#608902	Drug metabolism, poor, cyp2d6-related	P10635
#181350	Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2	P02545
#608013	Gaucher disease, perinatal lethal	P04062
#230800	Gaucher disease, type i	P04062
#230900	Gaucher disease, type ii	P04062
#231000	Gaucher disease, type iii	P04062
#231005	Gaucher disease, type iiic	P04062
#610140	Heart-hand syndrome, slovenian type	P02545
#176670	Hutchinson-gilford progeria syndrome; hgps	P02545
#151660	Lipodystrophy, familial partial, type 2; fpld2	P02545
#248370	Mandibuloacral dysplasia with type a lipodystrophy; mada	P02545
#248510	Mannosidosis, beta a, lysosomal; mansb	O00462
#613205	Muscular dystrophy, congenital, lmna-related	P02545
#159001	Muscular dystrophy, limb-girdle, type 1b; lgmd1b	P02545
#168600	Parkinson disease, late-onset; pd	P04062
#275210	Restrictive dermopathy, lethal	P02545
#188570	Thyroid hormone resistance, generalized, autosomal dominant; grth	P10828
#274300	Thyroid hormone resistance, generalized, autosomal recessive; grth	P10828
#145650	Thyroid hormone resistance, selective pituitary; prth	P10828

KEGG	name	UniProt
H00140	beta-Mannosidosis	O00462 (related)
H00422	Glycoproteinoses	O00462 (related)
H00264	Charcot-Marie-Tooth disease (CMT)	P02545 (related)
H00294	Dilated cardiomyopathy (DCM)	P02545 (related)
H00420	Familial partial lipodystrophy (FPL)	P02545 (related)
H00563	Emery-Dreifuss muscular dystrophy	P02545 (related)
H00590	Congenital muscular dystrophies (CMD/MDC)	P02545 (related)
H00593	Limb-girdle muscular dystrophy (LGMD)	P02545 (related)
H00601	Hutchinson-Gilford progeria syndrome	P02545 (related)
H00663	Restrictive dermopathy	P02545 (related)
H00665	Mandibuloacral dysplasia	P02545 (related)
H01216	Left ventricular noncompaction (LVNC)	P02545 (related)
H00066	Lewy body dementia (LBD)	P04062 (related)
H00126	Gaucher disease	P04062 (related)
H00426	Defects in the degradation of ganglioside	P04062 (related)
H00810	Progressive myoclonic epilepsy (PME)	P04062 (related)
H00036	Osteosarcoma	P08684 (marker)
H00249	Thyroid hormone resistance syndrome	P10828 (related)
H01205	Coumarin resistance	P11712 (related)
H01171	Poor drug metabolism (PM)	P33261 (related)