Plant Species


Cumulative plant class count

class name count
rosids 2
Liliopsida 1
Magnoliophyta 1

Cumulative family count

class name count
Fabaceae 2
Tricholomataceae 1
Asparagaceae 1
Annonaceae 1

KEGG BRITE br08003 External link 512


Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
figure
C00001490 External link 512 Adenine
CHEMBL226345
D000225
52 / 44 / 38 1 / 6

Human Protein / Gene in interactions

52 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 C00001490 1 / 1
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00001490 0 / 0
P08069 Insulin-like growth factor 1 receptor TK tyrosine-protein kinase INSR subfamily C00001490 1 / 3
Q16539 Mitogen-activated protein kinase 14 p38 C00001490 0 / 0
P22894 Neutrophil collagenase M10A C00001490 0 / 0
P42336 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Enzyme C00001490 9 / 1
P45984 Mitogen-activated protein kinase 9 Jnk C00001490 0 / 0
P17252 Protein kinase C alpha type Alpha C00001490 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00001490 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00001490 2 / 2
Q15303 Receptor tyrosine-protein kinase erbB-4 TK tyrosine-protein kinase EGFR subfamily C00001490 0 / 0
O14965 Aurora kinase A Aur C00001490 0 / 0
P02545 Prelamin-A/C Unclassified protein C00001490 11 / 10
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00001490 1 / 1
P11309 Serine/threonine-protein kinase pim-1 Pim C00001490 0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 C00001490 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00001490 1 / 8
P31751 RAC-beta serine/threonine-protein kinase Akt C00001490 2 / 2
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta Other serine/threonine protein kinase C00001490 0 / 0
Q13464 Rho-associated protein kinase 1 Rock C00001490 0 / 0
O43353 Receptor-interacting serine/threonine-protein kinase 2 Ripk C00001490 0 / 0
P07332 Tyrosine-protein kinase Fes/Fps Fer C00001490 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00001490 0 / 0
Q05397 Focal adhesion kinase 1 Fak C00001490 0 / 0
P03956 Interstitial collagenase M10A C00001490 0 / 1
Q99683 Mitogen-activated protein kinase kinase kinase 5 Ste11 C00001490 0 / 0
P15056 Serine/threonine-protein kinase B-raf Raf C00001490 6 / 3
Q99816 Tumor susceptibility gene 101 protein Unclassified protein C00001490 0 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00001490 5 / 9
Q96GD4 Aurora kinase B Aur C00001490 0 / 0
P49137 MAP kinase-activated protein kinase 2 CAMK serine/threonine protein kinase MAPKAPK C00001490 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00001490 0 / 0
P45983 Mitogen-activated protein kinase 8 Jnk C00001490 0 / 0
P08253 72 kDa type IV collagenase M10A C00001490 1 / 3
Q13177 Serine/threonine-protein kinase PAK 2 STE serine/threonine protein kinase PAKA subfamily C00001490 0 / 0
Q08881 Tyrosine-protein kinase ITK/TSK Tec C00001490 1 / 1
O00329 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Enzyme C00001490 0 / 0
P08238 Heat shock protein HSP 90-beta Other cytosolic protein C00001490 0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt C00001490 4 / 1
Q15118 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial Pdhk C00001490 0 / 0
O00141 Serine/threonine-protein kinase Sgk1 AGC serine/threonine protein kinase SGK subfamily C00001490 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001490 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00001490 0 / 1
P52333 Tyrosine-protein kinase JAK3 Jakb C00001490 1 / 1
P04049 RAF proto-oncogene serine/threonine-protein kinase Raf C00001490 2 / 0
P43405 Tyrosine-protein kinase SYK Syk C00001490 0 / 0
P08254 Stromelysin-1 M10A C00001490 1 / 0
P48736 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Enzyme C00001490 0 / 0
P22694 cAMP-dependent protein kinase catalytic subunit beta Pka C00001490 0 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka C00001490 0 / 0
P22612 cAMP-dependent protein kinase catalytic subunit gamma Pka C00001490 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00001490 1 / 1

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00001490

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (44)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#114480 Breast cancer P31749
P42336
#115150 Cardiofaciocutaneous syndrome 1; cfc1 P15056
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P15056
P31749
P42336
#612918 Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi P42336
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#615108 Cowden syndrome 5; cws5 P42336
#615109 Cowden syndrome 6; cws6 P31749
#125853 Diabetes mellitus, noninsulin-dependent; niddm P31751
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#137800 Glioma susceptibility 1; glm1 P04626
#610140 Heart-hand syndrome, slovenian type P02545
#114550 Hepatocellular carcinoma P42336
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#240900 Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh P31751
#270450 Insulin-like growth factor i, resistance to P08069
#603932 Intervertebral disc disease; idd P14780
#182000 Keratosis, seborrheic P42336
#611554 Leopard syndrome 2 P04049
#613707 Leopard syndrome 3 P15056
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P00533
P04626
P15056
#605027 Lymphoma, non-hodgkin, familial P15056
#613011 Lymphoproliferative syndrome 1; lpfs1 Q08881
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#602501 Megalencephaly-capillary malformation-polymicrogyria syndrome; mcap P42336
#603387 Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph P42336
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#611553 Noonan syndrome 5; ns5 P04049
#613706 Noonan syndrome 7; ns7 P15056
#167000 Ovarian cancer P04626
P42336
#176920 Proteus syndrome P31749
#275210 Restrictive dermopathy, lethal P02545
#600802 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative P52333
#278300 Xanthinuria, type i P47989

KEGG DISEASE (38)

KEGG name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P08253 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P31751 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00019 Pancreatic cancer P04626 (related)
H00026 Endometrial Cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
P31751 (related)
P42336 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00015 Malignant pleural mesothelioma P08069 (related)
H00050 Synovial sarcoma P08069 (related)
H01274 Growth delay due to insulin-like growth factor I resistance P08069 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00032 Thyroid cancer P15056 (related)
H00038 Malignant melanoma P15056 (related)
H00523 Noonan syndrome and related disorders P15056 (related)
Q02750 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H00192 Xanthinuria P47989 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P52333 (related)
H00107 Other well-defined immunodeficiency syndromes Q08881 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)

Diseases related to CTD interactions

6 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000855 Anorexia C00001490
D002779 Cholestasis C00001490
D056486 Drug-Induced Liver Injury C00001490
D007565 Jaundice C00001490
D009325 Nausea C00001490
D051437 Renal Insufficiency C00001490