KCF-S cluster No. 660 (13 metabolites)

Corresponding Phytochemical cluster No. 46

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (13)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	13

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Cumulative family count

class name	count
Acanthaceae	12
Asteraceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Labdanes	1

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metabolites link (1)

br08003 Category	KEGG ID	KNApSAcK ID
Labdanes	C20214	C00023362

Metabolite list (13)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00022229	ent-2alpha-2,18-Dihydroxy-8(17),13-labdadien-15,16-olide
C00022230	Phlogantholide A
C00022232	14-Deoxyandrographolide	CHEMBL415768
C00022255	14-Deoxy-11-oxoandrographolide
C00023362	Andrographolide	CHEMBL186141 CHEMBL191892 CHEMBL364257 CHEMBL479285 CHEMBL466345 CHEMBL1317036 CHEMBL1317931 CHEMBL1599649 CHEMBL1705045 CHEMBL1951638	C030419	21 / 28 / 58	22 / 5
C00023363	Wightionolide
C00038155	12R,13R-Hydroxyandrographolide	CHEMBL518455 CHEMBL467963 CHEMBL467946
C00038156	12S,13S-Hydroxyandrographolide	CHEMBL518455 CHEMBL467963 CHEMBL467946
C00038325	7R-Hydroxy-14-deoxyandrographolide	CHEMBL466745 CHEMBL512623
C00038326	7S-Hydroxy-14-deoxyandrographolide	CHEMBL466745 CHEMBL512623
C00041241	12S-Hydroxyandrographolide / (-)-12S-Hydroxyandrographolide	CHEMBL518455 CHEMBL467963 CHEMBL467946
C00041244	14-Deoxy-17-hydroxyandrographolide / (-)-14-Deoxy-17-hydroxyandrographolide	CHEMBL479489
C00041336	Andropanolide / (-)-Andropanolide	CHEMBL186141 CHEMBL191892 CHEMBL364257 CHEMBL479285 CHEMBL466345 CHEMBL1317036 CHEMBL1317931 CHEMBL1599649 CHEMBL1705045 CHEMBL1951638		21 / 28 / 58

Human Protein / Gene in interactions

21 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P04637	Cellular tumor antigen p53	Transcription Factor	C00023362 C00041336	7 / 37
Q99700	Ataxin-2	Unclassified protein	C00023362 C00041336	1 / 1
Q9H227	Cytosolic beta-glucosidase	Enzyme	C00023362 C00041336	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00023362 C00041336	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00023362 C00041336	11 / 10
P04278	Sex hormone-binding globulin	Secreted protein	C00023362 C00041336	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00023362 C00041336	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00023362 C00041336	2 / 0
O75496	Geminin	Unclassified protein	C00023362 C00041336	0 / 0
Q04206	Transcription factor p65	Transcription Factor	C00023362 C00041336	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00023362 C00041336	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00023362 C00041336	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00023362 C00041336	0 / 0
P31749	RAC-alpha serine/threonine-protein kinase	Akt	C00023362 C00041336	4 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00023362 C00041336	0 / 1
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00023362 C00041336	0 / 0
O43451	Maltase-glucoamylase, intestinal	Hydrolase	C00023362 C00041336	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00023362 C00041336	1 / 0
O00255	Menin	Unclassified protein	C00023362 C00041336	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00023362 C00041336	1 / 2
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00023362 C00041336	0 / 3

22 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
581	BAX, BCL2L4	BCL2-associated X protein	C00023362
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00023362
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00023362
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00023362
890	CCNA2, CCN1, CCNA	cyclin A2	C00023362
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00023362
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00023362
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00023362
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00023362
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00023362
1559	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00023362
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00023362
54583	EGLN1, C1orf12, ECYT3, HIF-PH2, HIFPH2, HPH-2, HPH2, PHD2, SM20, ZMYND6	egl-9 family hypoxia-inducible factor 1 (EC:1.14.11.29)	C00023362
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00023362
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00023362
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00023362
4316	MMP7, MMP-7, MPSL1, PUMP-1	matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23)	C00023362
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00023362
259296	TAS2R50, T2R50, T2R51, TAS2R51	taste receptor, type 2, member 50	C00023362
7040	TGFB1, CED, DPD1, LAP, TGFB, TGFbeta	transforming growth factor, beta 1	C00023362
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00023362
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00023362

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions