KCF-S cluster No. 672 (13 metabolites)
Corresponding Phytochemical cluster No. 4
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| asterids | 46 |
Cumulative family count
| class name | count |
|---|---|
| Loganiaceae | 46 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Indole alkaloids | 2 |
metabolites link (3)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|---|---|
| Indole alkaloids | C09084 | C00001695 |
| Indole alkaloids | C06522 | C00001770 |
| Indole alkaloids | C06522 | C00025213 |
Metabolite list (13)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00001695
|
Brucine
|
CHEMBL501756
CHEMBL1333042 CHEMBL1515857 CHEMBL1573549 CHEMBL2361237 |
C083806
|
11 / 24 / 21 | 11 / 8 |
|
|
C00001770
|
Strychnine
|
CHEMBL33495
CHEMBL227934 CHEMBL1436908 CHEMBL1446958 CHEMBL1609139 |
D013331
|
102 / 46 / 46 | 5 / 5 |
|
|
C00025153
|
alpha-Colubrine
|
CHEMBL2164940
|
|
|||
|
C00025155
|
beta-Colubrine
|
CHEMBL1994566
|
|
|||
|
C00025156
|
Brucine N-oxide
|
CHEMBL343357
|
C083067
|
5 / 3 / 0 | 5 / 0 |
|
|
C00025165
|
Diaboline
|
CHEMBL1969794
|
|
|||
|
C00025199
|
Pseudobrucine
/ 16-Hydroxybrucine |
CHEMBL2004313
CHEMBL2164941 |
|
|||
|
C00025200
|
Pseudostrychnine
|
CHEMBL1970129
CHEMBL2164943 |
|
|||
|
C00025213
|
Certox
/ Strychnine / (-)-Strychnine |
CHEMBL33495
CHEMBL227934 CHEMBL1436908 CHEMBL1446958 CHEMBL1609139 |
D013331
|
102 / 46 / 46 | 5 / 5 |
|
|
C00027669
|
12-Hydroxy-11-methoxydiaboline
|
|
||||
|
C00029380
|
11-Methoxydiaboline
|
|
||||
|
C00037174
|
Genostrychnine
|
CHEMBL138585
|
C083068
|
4 / 3 / 0 |
|
|
|
C00037693
|
Protostrychnine
|
|
Human Protein / Gene in interactions
105 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00001695 C00001770 C00025156 C00025213 C00037174 | 1 / 0 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00001695 C00001770 C00025156 C00025213 C00037174 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00001695 C00001770 C00025156 C00025213 C00037174 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00001695 C00001770 C00025156 C00025213 C00037174 | 0 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00001695 C00001770 C00025156 C00025213 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00001695 C00001770 C00025213 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001695 C00001770 C00025213 | 1 / 2 |
| O75496 | Geminin | Unclassified protein | C00001695 C00001770 C00025213 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00001770 C00025213 | 1 / 1 |
| P29466 | Caspase-1 | C14 | C00001770 C00025213 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00001770 C00025213 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00001770 C00025213 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00001770 C00025213 | 2 / 2 |
| Q99250 | Sodium channel protein type 2 subunit alpha | SCN alpha, NaV1.x | C00001770 C00025213 | 2 / 2 |
| P23415 | Glycine receptor subunit alpha-1 | GLR alpha | C00001770 C00025213 | 1 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00001770 C00025213 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00001770 C00025213 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00001770 C00025213 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00001770 C00025213 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00001770 C00025213 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00001770 C00025213 | 1 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001770 C00025213 | 1 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00001770 C00025213 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00001770 C00025213 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00001770 C00025213 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00001770 C00025213 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00001770 C00025213 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001770 C00025213 | 0 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00001770 C00025213 | 1 / 8 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00001770 C00025213 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00001770 C00025213 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00001770 C00025213 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00001770 C00025213 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00001770 C00025213 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00001770 C00025213 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00001770 C00025213 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00001770 C00025213 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00001770 C00025213 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00001770 C00025213 | 1 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00001770 C00025213 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001770 C00025213 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00001770 C00025213 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00001770 C00025213 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00001770 C00025213 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00001770 C00025213 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00001770 C00025213 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00001770 C00025213 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00001770 C00025213 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00001770 C00025213 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00001770 C00025213 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00001770 C00025213 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00001770 C00025213 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00001770 C00025213 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00001770 C00025213 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00001770 C00025213 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00001770 C00025213 | 1 / 0 |
| P03956 | Interstitial collagenase | M10A | C00001770 C00025213 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00001770 C00025213 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00001770 C00025213 | 0 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00001770 C00025213 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00001770 C00025213 | 2 / 1 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00001770 C00025213 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00001770 C00025213 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00001770 C00025213 | 5 / 9 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00001770 C00025213 | 2 / 2 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00001770 C00025213 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00001770 C00025213 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00001770 C00025213 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00001770 C00025213 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00001770 C00025213 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00001770 C00025213 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00001770 C00025213 | 2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001770 C00025213 | 0 / 0 |
| Q9NY46 | Sodium channel protein type 3 subunit alpha | SCN alpha, NaV1.x | C00001770 C00025213 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00001770 C00025213 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00001770 C00025213 | 0 / 0 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00001770 C00025213 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00001770 C00025213 | 1 / 0 |
| P24046 | Gamma-aminobutyric acid receptor subunit rho-1 | GABA-A rho | C00001770 C00025213 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00001770 C00025213 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00001770 C00025213 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00001770 C00025213 | 0 / 3 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00001770 C00025213 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00001770 C00025213 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00001770 C00025213 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001770 C00025213 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001770 C00025213 | 0 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00001770 C00025213 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00001770 C00025213 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00001770 C00025213 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00001770 C00025213 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00001770 C00025213 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00001770 C00025213 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00001770 C00025213 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00001770 C00025213 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00001770 C00025213 | 0 / 0 |
| P35498 | Sodium channel protein type 1 subunit alpha | SCN alpha, NaV1.x | C00001770 C00025213 | 3 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001770 C00025213 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001770 C00025213 | 1 / 4 |
| A8MPY1 | Gamma-aminobutyric acid receptor subunit rho-3 | GABA-A rho | C00001770 C00025213 | 0 / 0 |
| P28476 | Gamma-aminobutyric acid receptor subunit rho-2 | GABA-A rho | C00001770 C00025213 | 0 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00001770 C00025213 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001695 | 3 / 3 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001695 | 11 / 10 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00001695 | 4 / 1 |
13 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1131 | CHRM3, EGBRS, HM3 | cholinergic receptor, muscarinic 3 |
C00001695
C00001770
C00025156
C00025213
|
| 1129 | CHRM2, HM2 | cholinergic receptor, muscarinic 2 |
C00001695
C00001770
C00025156
C00025213
|
| 1132 | CHRM4, HM4, M4R | cholinergic receptor, muscarinic 4 |
C00001695
C00001770
C00025156
C00025213
|
| 2741 | GLRA1, HKPX1, STHE | glycine receptor, alpha 1 |
C00001695
C00001770
C00025213
|
| 1128 | CHRM1, HM1, M1, M1R | cholinergic receptor, muscarinic 1 |
C00001695
C00025156
|
| 6331 | SCN5A, CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1, VF1 | sodium channel, voltage-gated, type V, alpha subunit |
C00001770
C00025213
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00001695
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001695
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00001695
|
| 1133 | CHRM5, HM5 | cholinergic receptor, muscarinic 5 |
C00025156
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00001695
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00001695
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001695
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (64)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #607208 | Dravet syndrome |
P35498
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #613721 | Epileptic encephalopathy, early infantile, 11; eiee11 |
Q99250
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #604403 | Generalized epilepsy with febrile seizures plus, type 2; gefsp2 |
P35498
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #149400 | Hyperekplexia, hereditary 1; hkpx1 |
P23415
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #609634 | Migraine, familial hemiplegic, 3; fhm3 |
P35498
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #607745 | Seizures, benign familial infantile, 3; bfis3 |
Q99250
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (59)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00769 | Hyperekplexia |
P23415
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00775 | Familial or sporadic hemiplegic migraine |
P35498
(related)
|
| H00783 | Febrile seizures |
P35498
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
Q99714 (related) |
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
Q99250
(related)
|
| H00806 | Benign familial neonatal and infantile epilepsies |
Q99250
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
13 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D012640 | Seizures |
C00001770
C00025213 |
| D049188 | Prenatal Injuries |
C00001770
C00025213 |
| D009422 | Nervous System Diseases |
C00001770
C00025213 |
| D006930 | Hyperalgesia |
C00001770
C00025213 |
| D002375 | Catalepsy |
C00001770
C00025213 |
| D009374 | Neoplasms, Experimental |
C00001695
|
| D009101 | Multiple Myeloma |
C00001695
|
| D012206 | Rhabdomyolysis |
C00001695
|
| D008113 | Liver Neoplasms |
C00001695
|
| D002493 | Central Nervous System Diseases |
C00001695
|
| D002294 | Carcinoma, Squamous Cell |
C00001695
|
| D000741 | Anemia, Aplastic |
C00001695
|
| D058186 | Acute Kidney Injury |
C00001695
|