PCIDB

KCF-S cluster No. 6968 (1 metabolites)

class name	count

class name	count
Streptomycetaceae	1

br08003 Category	# of metabolite

br08003 Category	KEGG ID	KNApSAcK ID

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00039881	N-Phenyl-beta-naphthylamine	CHEMBL1543632	C011948	16 / 22 / 18

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00039881	2 / 2
P10828	Thyroid hormone receptor beta	NR1A2	C00039881	3 / 1
P00352	Retinal dehydrogenase 1	Enzyme	C00039881	0 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00039881	2 / 2
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00039881	2 / 0
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00039881	4 / 2
P83916	Chromobox protein homolog 1	Unclassified protein	C00039881	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00039881	3 / 3
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00039881	2 / 2
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00039881	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00039881	0 / 1
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00039881	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00039881	0 / 0
P10275	Androgen receptor	NR3C4	C00039881	3 / 4
P35869	Aryl hydrocarbon receptor	Transcription Factor	C00039881	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00039881	1 / 1

OMIM	preferred title	UniProt
#300438	17-beta-hydroxysteroid dehydrogenase x deficiency	Q99714
#612069	Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10	Q13148
#300068	Androgen insensitivity syndrome; ais	P10275
#312300	Androgen insensitivity, partial; pais	P10275
#114480	Breast cancer	P38398
#604370	Breast-ovarian cancer, familial, susceptibility to, 1; brovca1	P38398
#114500	Colorectal cancer; crc	P84022
#119900	Digital clubbing, isolated congenital	P15428
#259100	Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1	P15428
#613795	Loeys-dietz syndrome, type 3; lds3	P84022
#613688	Long qt syndrome 2; lqt2	Q12809
#300705	Mental retardation, x-linked 17; mrx17	Q99714
#300220	Mental retardation, x-linked, syndromic 10; mrxs10	Q99714
#257200	Niemann-pick disease, type a	P17405
#607616	Niemann-pick disease, type b	P17405
#167000	Ovarian cancer	P38398
#614320	Pancreatic cancer, susceptibility to, 4; pnca4	P38398
#609620	Short qt syndrome 1; sqt1	Q12809
#313200	Spinal and bulbar muscular atrophy, x-linked 1; smax1	P10275
#188570	Thyroid hormone resistance, generalized, autosomal dominant; grth	P10828
#274300	Thyroid hormone resistance, generalized, autosomal recessive; grth	P10828
#145650	Thyroid hormone resistance, selective pituitary; prth	P10828

KEGG	name	UniProt
H00036	Osteosarcoma	P08684 (marker)
H00024	Prostate cancer	P10275 (related)
H00062	Spinal and bulbar muscular atrophy (SBMA)	P10275 (related)
H00608	46,XY disorders of sex development (Disorders in androgen synthesis or action)	P10275 (related)
H00609	46,XY disorders of sex development (Other)	P10275 (related)
H00249	Thyroid hormone resistance syndrome	P10828 (related)
H00457	Primary hypertrophic osteoarthropathy (PHO)	P15428 (related)
H01246	Isolated congenital nail clubbing (ICNC)	P15428 (related)
H00137	Niemann-Pick disease (NPD) typeA and B	P17405 (related)
H00424	Defects in the degradation of sphingomyelin	P17405 (related)
H00027	Ovarian cancer	P38398 (related)
H00031	Breast cancer	P38398 (related)
H00720	Long QT syndrome	Q12809 (related)
H00725	Short QT syndrome	Q12809 (related)
H00058	Amyotrophic lateral sclerosis (ALS)	Q13148 (related)
H00480	Non-syndromic X-linked mental retardation	Q99714 (related)
H00658	Syndromic X-linked mental retardation	Q99714 (related)
H00925	2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency	Q99714 (related)