PCIDB

KCF-S cluster No. 7212 (1 metabolites)

Plant Species

Cumulative plant class count

class name count
Liliopsida 1

Cumulative family count

class name count
Amaryllidaceae 1

KEGG BRITE br08003 External link 512

Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00001244 External link 512 Diallyl sulfide
CHEMBL170458
C038491
6 / 11 / 4 31 / 8

Human Protein / Gene in interactions

6 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q16637 Survival motor neuron protein Unclassified protein C00001244 4 / 1
P08183 Multidrug resistance protein 1 drug C00001244 1 / 0
O75762 Transient receptor potential cation channel subfamily A member 1 Unclassified protein C00001244 1 / 0
P37088 Amiloride-sensitive sodium channel subunit alpha NA C00001244 2 / 2
P51168 Amiloride-sensitive sodium channel subunit beta Unclassified protein C00001244 3 / 3
P51170 Amiloride-sensitive sodium channel subunit gamma Unclassified protein C00001244 2 / 3

31 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00001244
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00001244
8714 ABCC3, ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 C00001244
10257 ABCC4, EST170205, MOAT-B, MOATB, MRP4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 C00001244
581 BAX, BCL2L4 BCL2-associated X protein C00001244
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00001244
330 BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 baculoviral IAP repeat containing 3 C00001244
332 BIRC5, API4, EPR-1 baculoviral IAP repeat containing 5 C00001244
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001244
837 CASP4, ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX caspase 4, apoptosis-related cysteine peptidase (EC:3.4.22.57) C00001244
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00001244
831 CAST, BS-17 calpastatin C00001244
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00001244
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00001244
1548 CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) C00001244
24300 C00001244
361523 C00001244
1555 CYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450 cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) C00001244
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00001244
56616 DIABLO, DFNA64, SMAC diablo, IAP-binding mitochondrial protein C00001244
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00001244
1647 GADD45A, DDIT1, GADD45 growth arrest and DNA-damage-inducible, alpha C00001244
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00001244
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00001244
10397 NDRG1, CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5 N-myc downstream regulated 1 C00001244
1728 NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) C00001244
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00001244
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00001244
6720 SREBF1, SREBP-1c, SREBP1, bHLHd1 sterol regulatory element binding transcription factor 1 C00001244
7296 TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR thioredoxin reductase 1 (EC:1.8.1.9) C00001244
331 XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 X-linked inhibitor of apoptosis C00001244

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (11)

OMIM preferred title UniProt
#211400 Bronchiectasis with or without elevated sweat chloride 1; besc1 P51168
#613021 Bronchiectasis with or without elevated sweat chloride 2; besc2 P37088
#613071 Bronchiectasis with or without elevated sweat chloride 3; besc3 P51170
#615040 Episodic pain syndrome, familial, 1; feps1 O75762
#612244 Inflammatory bowel disease 13; ibd13 P08183
#177200 Liddle syndrome P51168
P51170
#264350 Pseudohypoaldosteronism, type i, autosomal recessive; pha1b P37088
P51168
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637

KEGG DISEASE (4)

KEGG name UniProt
H00243 Hyperkalemic distal renal tubular acidosis (RTA type 4) P37088 (related)
P51168 (related)
P51170 (related)
H00892 Bronchiectasis with or without elevated sweat chloride P37088 (related)
P51168 (related)
P51170 (related)
H00242 Liddle syndrome P51168 (related)
P51170 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)

Diseases related to CTD interactions

8 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001943 Breast Neoplasms C00001244
D056486 Drug-Induced Liver Injury C00001244
D005235 Fatty Liver, Alcoholic C00001244
D006525 Hepatitis, Viral, Human C00001244
D006965 Hyperplasia C00001244
D008113 Liver Neoplasms C00001244
D009404 Nephrotic Syndrome C00001244
D012878 Skin Neoplasms C00001244